Article(id=1226236830903877849, tenantId=1146029695717560320, journalId=1192105938417971205, issueId=1226236828399878330, articleNumber=null, orderNo=null, doi=10.13343/j.cnki.wsxb.20240704, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1730995200000, receivedDateStr=2024-11-08, revisedDate=null, revisedDateStr=null, acceptedDate=1737388800000, acceptedDateStr=2025-01-21, onlineDate=1770287242866, onlineDateStr=2026-02-05, pubDate=1746288000000, pubDateStr=2025-05-04, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1770287242866, onlineIssueDateStr=2026-02-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1770287242866, creator=13701087609, updateTime=1770287242866, updator=13701087609, issue=Issue{id=1226236828399878330, tenantId=1146029695717560320, journalId=1192105938417971205, year='2025', volume='65', issue='5', pageStart='1831', pageEnd='2319', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1770287242269, creator=13701087609, updateTime=1770344517883, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1226477059812274835, tenantId=1146029695717560320, journalId=1192105938417971205, issueId=1226236828399878330, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1226477059816469140, tenantId=1146029695717560320, journalId=1192105938417971205, issueId=1226236828399878330, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=2267, endPage=2279, ext={EN=ArticleExt(id=1226236831189090531, articleId=1226236830903877849, tenantId=1146029695717560320, journalId=1192105938417971205, language=EN, title=Prokaryotic expression and immune effect evaluation of PRRSV nonstructural protein NSP1, columnId=1192149543992045670, journalTitle=Acta Microbiologica Sinica, columnName=Research Article, runingTitle=null, highlight=null, articleAbstract=

[Objective] To express the recombinant nonstructural protein NSP1 of the porcine reproductive and respiratory syndrome virus (PRRSV) strain NADC 30, evaluate its immune effect in mice, and explore the potential value of the nonstructural proteins of PRRSV as vaccine antigens. [Methods] The prokaryotic expression system was used to express NSP1 of NADC30. After purification, the expression and antibody reactivity of NSP1 in vitro were identified by Western blotting. After mice were immunized with NSP1, the levels of cellular and humoral immunity induced by NSP1 were measured. The level of neutralizing antibody induced by NSP1 was evaluated by the virus neutralization assay. [Results] The target gene of NSP1 was connected to the Escherichia coli pET-28a vector for prokaryotic expression. Western blotting identified that the recombinant protein NSP1 was correctly expressed and had antibody reactivity. After mice were immunized with the confirmed recombinant protein NSP1, the levels of interferon (IFN)-γ and tumor necrosis factor (TNF)-α in the spleen lymphocytes of mice were elevated, and cellular immunity was stimulated. At the same time, the recombinant protein NSP1 significantly improved the proliferation of spleen lymphocytes in mice. ELISA results suggested that the level of specific antibodies in the serum rose after immunization. Further analysis of the specific antibody subtypes (IgG2a and IgG1) produced showed that the type of immunity stimulated by recombinant NSP1 was biased to Th2 humoral immunity. In addition, the virus neutralization assay showed that the recombinant protein NSP1 had a good virus neutralization ability, with the neutralization titer of 1:37 on day 28 and 1:31 on day 42, which were significantly higher than those of the PBS control group and had no difference from those of the commercial vaccine group. [Conclusion] The recombinant nonstructural protein NSP1 of PRRSV can stimulate cellular and humoral immunity in mice and has a good virus neutralization ability, which provides a new idea for the development of next-generation PRRSV vaccines.

, correspAuthors=null, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Wenxing WANG, Honghuan LI, Xiaoxiao GU, Ziwei LIU, Aodi WU, Mingguo XU, Zhongchen MA, Chuangfu CHEN), CN=ArticleExt(id=1226236834829746521, articleId=1226236830903877849, tenantId=1146029695717560320, journalId=1192105938417971205, language=CN, title=PRRSV重组非结构蛋白NSP1表达及免疫效果评价, columnId=1192149544164012138, journalTitle=微生物学报, columnName=研究报告, runingTitle=null, highlight=null, articleAbstract=

【目的】表达并获取猪繁殖与呼吸综合征病毒(porcine reproductive and respiratory syndrome virus, PRRSV) NADC 30毒株的重组非结构蛋白NSP1，评估其在小鼠体内的免疫效果，并探究PRRSV非结构蛋白作为疫苗抗原的潜在应用价值。【方法】利用原核表达系统表达PRRSV NADC30毒株的NSP1蛋白，纯化后通过Western blotting验证NSP1的体外表达及其抗体反应性；将纯化后的重组NSP1蛋白免疫小鼠，测定其在小鼠体内诱导的细胞免疫和体液免疫水平；通过病毒中和试验评价重组蛋白NSP1诱导的中和抗体水平。【结果】将NSP1目的基因连接至大肠杆菌pET-28a载体并进行原核表达，Western blotting结果显示，重组非结构蛋白NSP1能够正确表达，并且具有抗体反应性。经鉴定正确的重组蛋白NSP1免疫小鼠后，能够提高小鼠脾淋巴细胞中IFN-γ和TNF-α的表达水平，刺激机体产生细胞免疫应答。同时，重组蛋白NSP1还能够显著增强小鼠脾淋巴细胞的增殖能力。ELISA检测结果显示，免疫小鼠血清中的特异性抗体水平升高，进一步分析特异性抗体亚型(IgG2a和IgG1)发现，重组蛋白NSP1刺激机体产生的免疫类型偏向于Th2型体液免疫；病毒中和试验表明，重组蛋白NSP1具有良好的病毒中和能力，在免疫后28 d时中和效价为1:37，42 d时中和效价为1:31，均显著高于PBS对照组，与商品化疫苗组无差异。【结论】PRRSV重组非结构蛋白NSP1免疫小鼠后能够刺激机体产生细胞免疫应答与体液免疫应答，并且具有良好的病毒中和能力，为新型PRRSV疫苗的开发提供了潜在的新思路。

, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=6Tw+3XPDxNCJdNBR9zy6+w==, magXml=fdNBcTp1tGIZYZApQ5BYBA==, pdfUrl=null, pdf=gRaS356+f6s9tFJn3NB8Yg==, pdfFileSize=3759933, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=szd11hvyFIjDIcSafTLWgQ==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=ycosrMjJlMUjjpicKbmebQ==, mapNumber=null, authorCompany=null, fund=null, authors=, authorsList=王文星, 李红欢, 顾晓晓, 刘紫威, 吴澳迪, 徐明国, 马忠臣, 陈创夫)}, authors=[Author(id=1226592755175043308, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1226592755292483834, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, authorId=1226592755175043308, language=EN, stringName=Wenxing WANG, firstName=Wenxing, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.College of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1226592755548336385, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, authorId=1226592755175043308, language=CN, stringName=王文星, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.石河子大学 动物科技学院，新疆 石河子, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1226592753488933061, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, xref=1., ext=[AuthorCompanyExt(id=1226592753505710280, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, companyId=1226592753488933061, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.College of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, China), AuthorCompanyExt(id=1226592753518293192, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, companyId=1226592753488933061, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.石河子大学 动物科技学院，新疆 石河子)])]), Author(id=1226592755724497165, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1226592755892269346, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, authorId=1226592755724497165, language=EN, stringName=Honghuan LI, firstName=Honghuan, middleName=null, lastName=LI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.College of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1226592756001321262, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, authorId=1226592755724497165, language=CN, stringName=李红欢, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.石河子大学 动物科技学院，新疆 石河子, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1226592753488933061, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, xref=1., ext=[AuthorCompanyExt(id=1226592753505710280, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, companyId=1226592753488933061, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.College of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, China), AuthorCompanyExt(id=1226592753518293192, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, companyId=1226592753488933061, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.石河子大学 动物科技学院，新疆 石河子)])]), Author(id=1226592756118761783, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1226592756257173830, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, authorId=1226592756118761783, language=EN, stringName=Xiaoxiao GU, firstName=Xiaoxiao, middleName=null, lastName=GU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.College of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1226592756378808654, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, authorId=1226592756118761783, language=CN, stringName=顾晓晓, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.石河子大学 动物科技学院，新疆 石河子, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1226592753488933061, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, xref=1., ext=[AuthorCompanyExt(id=1226592753505710280, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, companyId=1226592753488933061, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.College of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, China), AuthorCompanyExt(id=1226592753518293192, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, companyId=1226592753488933061, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.石河子大学 动物科技学院，新疆 石河子)])]), Author(id=1226592756538192220, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1226592756664021350, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, authorId=1226592756538192220, language=EN, stringName=Ziwei LIU, firstName=Ziwei, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.College of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1226592756781461871, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, authorId=1226592756538192220, language=CN, stringName=刘紫威, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.石河子大学 动物科技学院，新疆 石河子, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1226592753488933061, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, xref=1., ext=[AuthorCompanyExt(id=1226592753505710280, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, companyId=1226592753488933061, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.College of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, China), AuthorCompanyExt(id=1226592753518293192, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, companyId=1226592753488933061, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.石河子大学 动物科技学院，新疆 石河子)])]), Author(id=1226592756911485307, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1226592757054091654, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, authorId=1226592756911485307, language=EN, stringName=Aodi WU, firstName=Aodi, middleName=null, lastName=WU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.College of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1226592757171532179, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, authorId=1226592756911485307, language=CN, stringName=吴澳迪, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.石河子大学 动物科技学院，新疆 石河子, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1226592753488933061, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, xref=1., ext=[AuthorCompanyExt(id=1226592753505710280, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, companyId=1226592753488933061, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.College of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, China), AuthorCompanyExt(id=1226592753518293192, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, companyId=1226592753488933061, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.石河子大学 动物科技学院，新疆 石河子)])]), Author(id=1226592757263806877, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1226592757377053095, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, authorId=1226592757263806877, language=EN, stringName=Mingguo XU, firstName=Mingguo, middleName=null, lastName=XU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.College of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1226592757494493613, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, authorId=1226592757263806877, language=CN, stringName=徐明国, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.石河子大学 动物科技学院，新疆 石河子, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1226592753488933061, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, xref=1., ext=[AuthorCompanyExt(id=1226592753505710280, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, companyId=1226592753488933061, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.College of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, China), AuthorCompanyExt(id=1226592753518293192, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, companyId=1226592753488933061, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.石河子大学 动物科技学院，新疆 石河子)])]), Author(id=1226592757624517047, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=zhongchen_ma@163.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1226592757779706303, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, authorId=1226592757624517047, language=EN, stringName=Zhongchen MA, firstName=Zhongchen, middleName=null, lastName=MA, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2, 3}, address=^1.College of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, China
^2.Collaborative Innovation Center for Sheep Health Breeding and Zoonotic Disease Prevention and Control, Shihezi University, Shihezi, Xinjiang, China
^3.International Joint Research Center for Animal Health, Shihezi University, Shihezi, Xinjiang, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1226592757888758214, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, authorId=1226592757624517047, language=CN, stringName=马忠臣, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2, 3}, address=^1.石河子大学 动物科技学院，新疆 石河子
^2.石河子大学，绵羊健康养殖与人兽共患病防控协同创新中心，新疆 石河子
^3.石河子大学，动物健康养殖国际联合研究中心，新疆 石河子, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1226592753488933061, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, xref=1., ext=[AuthorCompanyExt(id=1226592753505710280, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, companyId=1226592753488933061, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.College of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, China), AuthorCompanyExt(id=1226592753518293192, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, companyId=1226592753488933061, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.石河子大学 动物科技学院，新疆 石河子)]), AuthorCompany(id=1226592754877247700, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, xref=2., ext=[AuthorCompanyExt(id=1226592754881442006, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, companyId=1226592754877247700, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Collaborative Innovation Center for Sheep Health Breeding and Zoonotic Disease Prevention and Control, Shihezi University, Shihezi, Xinjiang, China), AuthorCompanyExt(id=1226592754889830616, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, companyId=1226592754877247700, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.石河子大学，绵羊健康养殖与人兽共患病防控协同创新中心，新疆 石河子)]), AuthorCompany(id=1226592754998882528, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, xref=3., ext=[AuthorCompanyExt(id=1226592755007271135, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, companyId=1226592754998882528, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^3.International Joint Research Center for Animal Health, Shihezi University, Shihezi, Xinjiang, China), AuthorCompanyExt(id=1226592755032436961, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, companyId=1226592754998882528, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^3.石河子大学，动物健康养殖国际联合研究中心，新疆 石河子)])]), Author(id=1226592758031364560, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, orderNo=7, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=ccf-xb@163.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1226592759449039325, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, authorId=1226592758031364560, language=EN, stringName=Chuangfu CHEN, firstName=Chuangfu, middleName=null, lastName=CHEN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2, 3}, address=^1.College of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, China
^2.Collaborative Innovation Center for Sheep Health Breeding and Zoonotic Disease Prevention and Control, Shihezi University, Shihezi, Xinjiang, China
^3.International Joint Research Center for Animal Health, Shihezi University, Shihezi, Xinjiang, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1226592759579062755, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, authorId=1226592758031364560, language=CN, stringName=陈创夫, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2, 3}, address=^1.石河子大学 动物科技学院，新疆 石河子
^2.石河子大学，绵羊健康养殖与人兽共患病防控协同创新中心，新疆 石河子
^3.石河子大学，动物健康养殖国际联合研究中心，新疆 石河子, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1226592753488933061, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, xref=1., ext=[AuthorCompanyExt(id=1226592753505710280, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, companyId=1226592753488933061, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.College of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, China), AuthorCompanyExt(id=1226592753518293192, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, companyId=1226592753488933061, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.石河子大学 动物科技学院，新疆 石河子)]), AuthorCompany(id=1226592754877247700, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, xref=2., ext=[AuthorCompanyExt(id=1226592754881442006, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, companyId=1226592754877247700, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Collaborative Innovation Center for Sheep Health Breeding and Zoonotic Disease Prevention and Control, Shihezi University, Shihezi, Xinjiang, China), AuthorCompanyExt(id=1226592754889830616, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, companyId=1226592754877247700, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.石河子大学，绵羊健康养殖与人兽共患病防控协同创新中心，新疆 石河子)]), AuthorCompany(id=1226592754998882528, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, xref=3., ext=[AuthorCompanyExt(id=1226592755007271135, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, companyId=1226592754998882528, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^3.International Joint Research Center for Animal Health, Shihezi University, Shihezi, Xinjiang, China), AuthorCompanyExt(id=1226592755032436961, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, companyId=1226592754998882528, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^3.石河子大学，动物健康养殖国际联合研究中心，新疆 石河子)])])], keywords=[Keyword(id=1226592759813943794, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, language=EN, orderNo=1, keyword=porcine reproductive and respiratory syndrome virus), Keyword(id=1226592759914607104, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, language=EN, orderNo=2, keyword=recombinant protein NSP1), Keyword(id=1226592760032047626, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, language=EN, orderNo=3, keyword=immune evaluation), Keyword(id=1226592760120128017, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, language=EN, orderNo=4, keyword=vaccine), Keyword(id=1226592760233374237, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, language=CN, orderNo=1, keyword=猪繁殖与呼吸综合征病毒), Keyword(id=1226592760342426144, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, language=CN, orderNo=2, keyword=重组蛋白NSP1), Keyword(id=1226592760522781223, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, language=CN, orderNo=3, keyword=免疫评价), Keyword(id=1226592760636027441, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, language=CN, orderNo=4, keyword=疫苗)], refs=[Reference(id=1226592768689091290, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, doi=null, pmid=null, pmcid=null, year=2024, volume=44, issue=8, pageStart=1831, pageEnd=1840, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=刘爱军, 黄晓兵, 章杭建, 周彩琴, 安慧婷, 张传亮, journalName=中国兽医学报, refType=null, unstructuredReference=刘爱军, 黄晓兵, 章杭建, 周彩琴, 安慧婷, 张传亮. 猪繁殖与呼吸综合征病毒天然免疫逃逸机制研究进展[J]. 中国兽医学报, 2024, 44(8): 1831-1840., articleTitle=猪繁殖与呼吸综合征病毒天然免疫逃逸机制研究进展, refAbstract=null), Reference(id=1226592768806531807, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, doi=null, pmid=null, pmcid=null, year=2024, volume=44, issue=8, pageStart=1831, pageEnd=1840, url=null, language=null, rfNumber=[1], rfOrder=1, authorNames=LIU AJ, HUANG XB, ZHANG HJ, ZHOU CQ, AN HT, ZHANG CL, journalName=Chinese Journal of Veterinary Science, refType=null, unstructuredReference=LIU AJ, HUANG XB, ZHANG HJ, ZHOU CQ, AN HT, ZHANG CL. Progress inevasion mechanisms of innate immunity by porcine reproductive and re-spiratory syndrome virus[J]. Chinese Journal of Veterinary Science, 2024, 44(8): 1831-1840 (in Chinese)., articleTitle=null, refAbstract=null), Reference(id=1226592768961721064, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, doi=null, pmid=null, pmcid=null, year=2022, volume=12, issue=11, pageStart=1381, pageEnd=null, url=null, language=null, rfNumber=[2], rfOrder=2, authorNames=ZHANG H, SHA HY, QIN LM, WANG NN, KONG WL, HUANG LZ, ZHAO MM, journalName=Animals, refType=null, unstructuredReference=ZHANG H, SHA HY, QIN LM, WANG NN, KONG WL, HUANG LZ, ZHAO MM. Research progress in porcine reproductive and respiratory syndrome virus-host protein interactions[J]. Animals, 2022, 12(11): 1381., articleTitle=Research progress in porcine reproductive and respiratory syndrome virus-host protein interactions, refAbstract=null), Reference(id=1226592769087550188, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, doi=null, pmid=null, pmcid=null, year=2010, volume=154, issue=1/2, pageStart=61, pageEnd=76, url=null, language=null, rfNumber=[3], rfOrder=3, authorNames=FANG Y, SNIJDER EJ, journalName=Virus Research, refType=null, unstructuredReference=FANG Y, SNIJDER EJ. The PRRSV replicase: exploring the multifunctionality of an intriguing set of nonstructural proteins[J]. Virus Research, 2010, 154(1/2): 61-76., articleTitle=The PRRSV replicase: exploring the multifunctionality of an intriguing set of nonstructural proteins, refAbstract=null), Reference(id=1226592769255322357, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, doi=null, pmid=null, pmcid=null, year=2023, volume=14, issue=null, pageStart=1140449, pageEnd=null, url=null, language=null, rfNumber=[4], rfOrder=4, authorNames=CHEN XX, QIAO SL, LI R, WANG J, LI XW, ZHANG GP, journalName=Frontiers in Microbiology, refType=null, unstructuredReference=CHEN XX, QIAO SL, LI R, WANG J, LI XW, ZHANG GP. Evasion strategies of porcine reproductive and respiratory syndrome virus[J]. Frontiers in Microbiology, 2023, 14: 1140449., articleTitle=Evasion strategies of porcine reproductive and respiratory syndrome virus, refAbstract=null), Reference(id=1226592769381151480, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, doi=null, pmid=null, pmcid=null, year=2008, volume=89, issue=null, pageStart=494, pageEnd=499, url=null, language=null, rfNumber=[5], rfOrder=5, authorNames=KROESE MV, ZEVENHOVEN-DOBBE JC, BOS-DE RUIJTER JNA, PEETERS BPH, MEULENBERG JJM, CORNELISSEN LAHM, SNIJDER EJ, journalName=The Journal of General Virology, refType=null, unstructuredReference=KROESE MV, ZEVENHOVEN-DOBBE JC, BOS-DE RUIJTER JNA, PEETERS BPH, MEULENBERG JJM, CORNELISSEN LAHM, SNIJDER EJ. The nsp1alpha and nsp1 papain-like autoproteinases are essential for porcine reproductive and respiratory syndrome virus RNA synthesis[J]. The Journal of General Virology, 2008, 89(Pt 2): 494-499., articleTitle=The nsp1alpha and nsp1 papain-like autoproteinases are essential for porcine reproductive and respiratory syndrome virus RNA synthesis, refAbstract=null), Reference(id=1226592769486009088, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, doi=null, pmid=null, pmcid=null, year=2020, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[6], rfOrder=6, authorNames=韩广伟, journalName=null, refType=null, unstructuredReference=韩广伟. 两种弱毒疫苗对新发PRRSV-2的效力评价与PRRSV-2 NSP1β突变疫苗株、阻断单抗研制[D]. 杭州: 浙江大学博士学位论文, 2020., articleTitle=两种弱毒疫苗对新发PRRSV-2的效力评价与PRRSV-2 NSP1β突变疫苗株、阻断单抗研制, refAbstract=null), Reference(id=1226592769603449603, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, doi=null, pmid=null, pmcid=null, year=2020, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[6], rfOrder=7, authorNames=HAN GW, journalName=null, refType=null, unstructuredReference=HAN GW. Efficacy evaluation of two attenuated vaccines against newly emerging PRRSV-2 and development of mutant PRRSV-2 NSP1β vaccine strain and blocking monoclonal antibody[D]. Hangzhou: Doctoral Dissertation of Zhejiang University, 2020 (in Chinese)., articleTitle=null, refAbstract=null), Reference(id=1226592769704112904, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, doi=null, pmid=null, pmcid=null, year=2009, volume=83, issue=21, pageStart=10931, pageEnd=10940, url=null, language=null, rfNumber=[7], rfOrder=8, authorNames=SUN YN, XUE F, GUO Y, MA M, HAO N, ZHANG XC, LOU ZY, LI XM, RAO ZH, journalName=Journal of Virology, refType=null, unstructuredReference=SUN YN, XUE F, GUO Y, MA M, HAO N, ZHANG XC, LOU ZY, LI XM, RAO ZH. Crystal structure of porcine reproductive and respiratory syndrome virus leader protease Nsp1alpha[J]. Journal of Virology, 2009, 83(21): 10931-10940., articleTitle=Crystal structure of porcine reproductive and respiratory syndrome virus leader protease Nsp1alpha, refAbstract=null), Reference(id=1226592769800581902, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, doi=null, pmid=null, pmcid=null, year=2012, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[8], rfOrder=9, authorNames=宋艳华, journalName=null, refType=null, unstructuredReference=宋艳华. 猪繁殖与呼吸综合征病毒NSP1非结构蛋白B细胞表位和ORF3-7结构蛋白T细胞表位的解析[D]. 南京: 南京农业大学博士学位论文, 2012., articleTitle=猪繁殖与呼吸综合征病毒NSP1非结构蛋白B细胞表位和ORF3-7结构蛋白T细胞表位的解析, refAbstract=null), Reference(id=1226592769897050897, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, doi=null, pmid=null, pmcid=null, year=2012, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[8], rfOrder=10, authorNames=SONG YH, journalName=null, refType=null, unstructuredReference=SONG YH. Analysis of B cell epitope of NSP1 nonstructural protein and T cell epitope of ORF3-7 structural protein of porcine reproductive and respiratory syndrome virus[D]. Nanjing: Doctoral Dissertation of Nanjing Agricultural University, 2012 (in Chinese), articleTitle=null, refAbstract=null), Reference(id=1226592770027074324, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, doi=null, pmid=null, pmcid=null, year=2014, volume=458, issue=null, pageStart=136, pageEnd=150, url=null, language=null, rfNumber=[9], rfOrder=11, authorNames=HAN MY, KIM CY, ROWLAND RRR, FANG Y, KIM D, YOO D, journalName=Virology, refType=null, unstructuredReference=HAN MY, KIM CY, ROWLAND RRR, FANG Y, KIM D, YOO D. Biogenesis of non-structural protein 1 (nsp1) and nsp1-mediated type I interferon modulation in arteriviruses[J]. Virology, 2014, 458: 136-150., articleTitle=Biogenesis of non-structural protein 1 (nsp1) and nsp1-mediated type I interferon modulation in arteriviruses, refAbstract=null), Reference(id=1226592770106766107, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, doi=null, pmid=null, pmcid=null, year=2022, volume=8, issue=2, pageStart=610, pageEnd=618, url=null, language=null, rfNumber=[10], rfOrder=12, authorNames=CONTRERAS-LUNA MJ, FRAGOSO-GONZALEZ G, SEGURA-VELÁZQUEZ RA, CERVANTES-TORRES JB, ALONSO-MORALES R, LA RAMÍREZ-MARTÍNEZ, AYÓN-NÚÑEZ DA, BOBES RJ, SÁNCHEZ-BETANCOURT JI, journalName=Veterinary Medicine and Science, refType=null, unstructuredReference=CONTRERAS-LUNA MJ, FRAGOSO-GONZALEZ G, SEGURA-VELÁZQUEZ RA, CERVANTES-TORRES JB, ALONSO-MORALES R, LA RAMÍREZ-MARTÍNEZ, AYÓN-NÚÑEZ DA, BOBES RJ, SÁNCHEZ-BETANCOURT JI. Immunogenic and antigenic analysis of recombinant NSP1 and NSP11 of PRRS virus[J]. Veterinary Medicine and Science, 2022, 8(2): 610-618., articleTitle=Immunogenic and antigenic analysis of recombinant NSP1 and NSP11 of PRRS virus, refAbstract=null), Reference(id=1226592770220012324, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, doi=null, pmid=null, pmcid=null, year=2015, volume=7, issue=3, pageStart=873, pageEnd=886, url=null, language=null, rfNumber=[11], rfOrder=13, authorNames=RASCÓN-CASTELO E, BURGARA-ESTRELLA A, MATEU E, HERNÁNDEZ J, journalName=Viruses, refType=null, unstructuredReference=RASCÓN-CASTELO E, BURGARA-ESTRELLA A, MATEU E, HERNÁNDEZ J. Immunological features of the non-structural proteins of porcine reproductive and respiratory syndrome virus[J]. Viruses, 2015, 7(3): 873-886., articleTitle=Immunological features of the non-structural proteins of porcine reproductive and respiratory syndrome virus, refAbstract=null), Reference(id=1226592770312287018, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, doi=null, pmid=null, pmcid=null, year=2007, volume=88, issue=null, pageStart=1184, pageEnd=1195, url=null, language=null, rfNumber=[12], rfOrder=14, authorNames=JOHNSON CR, YU WQ, MURTAUGH MP, journalName=The Journal of General Virology, refType=null, unstructuredReference=JOHNSON CR, YU WQ, MURTAUGH MP. Cross-reactive antibody responses to nsp1 and nsp2 of porcine reproductive and respiratory syndrome virus[J]. The Journal of General Virology, 2007, 88(Pt 4): 1184-1195., articleTitle=Cross-reactive antibody responses to nsp1 and nsp2 of porcine reproductive and respiratory syndrome virus, refAbstract=null), Reference(id=1226592770417144623, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, doi=null, pmid=null, pmcid=null, year=2017, volume=8, issue=null, pageStart=1635, pageEnd=null, url=null, language=null, rfNumber=[13], rfOrder=15, authorNames=NAN YC, WU CY, GU GQ, SUN WY, ZHANG YJ, ZHOU EM, journalName=Frontiers in Microbiology, refType=null, unstructuredReference=NAN YC, WU CY, GU GQ, SUN WY, ZHANG YJ, ZHOU EM. Improved vaccine against PRRSV: current progress and future perspective[J]. Frontiers in Microbiology, 2017, 8: 1635., articleTitle=Improved vaccine against PRRSV: current progress and future perspective, refAbstract=null), Reference(id=1226592770584916790, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, doi=null, pmid=null, pmcid=null, year=2015, volume=203, issue=null, pageStart=56, pageEnd=65, url=null, language=null, rfNumber=[14], rfOrder=16, authorNames=ROBINSON SR, LI J, NELSON EA, MURTAUGH MP, journalName=Virus Research, refType=null, unstructuredReference=ROBINSON SR, LI J, NELSON EA, MURTAUGH MP. Broadly neutralizing antibodies against the rapidly evolving porcine reproductive and respiratory syndrome virus[J]. Virus Research, 2015, 203: 56-65., articleTitle=Broadly neutralizing antibodies against the rapidly evolving porcine reproductive and respiratory syndrome virus, refAbstract=null), Reference(id=1226592770702357307, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, doi=null, pmid=null, pmcid=null, year=2016, volume=4, issue=null, pageStart=129, pageEnd=154, url=null, language=null, rfNumber=[15], rfOrder=17, authorNames=LUNNEY JK, FANG Y, LADINIG A, CHEN NH, LI YH, ROWLAND B, RENUKARADHYA GJ, journalName=Annual Review of Animal Biosciences, refType=null, unstructuredReference=LUNNEY JK, FANG Y, LADINIG A, CHEN NH, LI YH, ROWLAND B, RENUKARADHYA GJ. Porcine reproductive and respiratory syndrome virus (PRRSV): pathogenesis and interaction with the immune system[J]. Annual Review of Animal Biosciences, 2016, 4: 129-154., articleTitle=Porcine reproductive and respiratory syndrome virus (PRRSV): pathogenesis and interaction with the immune system, refAbstract=null), Reference(id=1226592770798826304, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, doi=null, pmid=null, pmcid=null, year=2012, volume=2, issue=3, pageStart=256, pageEnd=263, url=null, language=null, rfNumber=[16], rfOrder=18, authorNames=CHAND RJ, TRIBLE BR, ROWLAND RR, journalName=Current Opinion in Virology, refType=null, unstructuredReference=CHAND RJ, TRIBLE BR, ROWLAND RR. Pathogenesis of porcine reproductive and respiratory syndrome virus[J]. Current Opinion in Virology, 2012, 2(3): 256-263., articleTitle=Pathogenesis of porcine reproductive and respiratory syndrome virus, refAbstract=null), Reference(id=1226592770937238345, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, doi=null, pmid=null, pmcid=null, year=2015, volume=33, issue=27, pageStart=3065, pageEnd=3072, url=null, language=null, rfNumber=[17], rfOrder=19, authorNames=RENUKARADHYA GJ, MENG XJ, CALVERT JG, ROOF M, LAGER KM, journalName=Vaccine, refType=null, unstructuredReference=RENUKARADHYA GJ, MENG XJ, CALVERT JG, ROOF M, LAGER KM. Inactivated and subunit vaccines against porcine reproductive and respiratory syndrome: current status and future direction[J]. Vaccine, 2015, 33(27): 3065-3072., articleTitle=Inactivated and subunit vaccines against porcine reproductive and respiratory syndrome: current status and future direction, refAbstract=null), Reference(id=1226592771058873164, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, doi=null, pmid=null, pmcid=null, year=2014, volume=194, issue=null, pageStart=100, pageEnd=109, url=null, language=null, rfNumber=[18], rfOrder=20, authorNames=HAN MY, YOO D, journalName=Virus Research, refType=null, unstructuredReference=HAN MY, YOO D. Modulation of innate immune signaling by nonstructural protein 1 (nsp1) in the family Arteriviridae[J]. Virus Research, 2014, 194: 100-109., articleTitle=Modulation of innate immune signaling by nonstructural protein 1 (nsp1) in the family Arteriviridae, refAbstract=null), Reference(id=1226592771180507989, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, doi=null, pmid=null, pmcid=null, year=2018, volume=117, issue=null, pageStart=224, pageEnd=232, url=null, language=null, rfNumber=[19], rfOrder=21, authorNames=CHEN Y, SONG TY, XIAO YL, WAN XP, YANG LY, LI JH, ZENG GZ, FANG PF, WANG ZZ, GAO R, journalName=Research in Veterinary Science, refType=null, unstructuredReference=CHEN Y, SONG TY, XIAO YL, WAN XP, YANG LY, LI JH, ZENG GZ, FANG PF, WANG ZZ, GAO R. Enhancement of immune response of piglets to PCV-2 vaccine by porcine IL-2 and fusion IL-4/6 gene entrapped in chitosan nanoparticles[J]. Research in Veterinary Science, 2018, 117: 224-232., articleTitle=Enhancement of immune response of piglets to PCV-2 vaccine by porcine IL-2 and fusion IL-4/6 gene entrapped in chitosan nanoparticles, refAbstract=null), Reference(id=1226592771289559901, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, doi=null, pmid=null, pmcid=null, year=2006, volume=8, issue=null, pageStart=S2, pageEnd=null, url=null, language=null, rfNumber=[20], rfOrder=22, authorNames=KISHIMOTO T, journalName=Arthritis Research & Therapy, refType=null, unstructuredReference=KISHIMOTO T. Interleukin-6: discovery of a pleiotropic cytokine[J]. Arthritis Research & Therapy, 2006, 8(): S2., articleTitle=Interleukin-6: discovery of a pleiotropic cytokine, refAbstract=Suppl 2), Reference(id=1226592771407000415, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, doi=null, pmid=null, pmcid=null, year=2017, volume=505, issue=null, pageStart=42, pageEnd=55, url=null, language=null, rfNumber=[21], rfOrder=23, authorNames=HAN MY, KE HZ, ZHANG QZ, YOO D, journalName=Virology, refType=null, unstructuredReference=HAN MY, KE HZ, ZHANG QZ, YOO D. Nuclear imprisonment of host cellular mRNA by nsp1β protein of porcine reproductive and respiratory syndrome virus[J]. Virology, 2017, 505: 42-55., articleTitle=Nuclear imprisonment of host cellular mRNA by nsp1β protein of porcine reproductive and respiratory syndrome virus, refAbstract=null), Reference(id=1226592772782732134, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, doi=null, pmid=null, pmcid=null, year=2010, volume=406, issue=2, pageStart=270, pageEnd=279, url=null, language=null, rfNumber=[22], rfOrder=24, authorNames=SUBRAMANIAM S, KWON B, BEURA LK, KUSZYNSKI CA, PATTNAIK AK, OSORIO FA, journalName=Virology, refType=null, unstructuredReference=SUBRAMANIAM S, KWON B, BEURA LK, KUSZYNSKI CA, PATTNAIK AK, OSORIO FA. Porcine reproductive and respiratory syndrome virus non-structural protein 1 suppresses tumor necrosis factor-alpha promoter activation by inhibiting NF-κB and Sp1[J]. Virology, 2010, 406(2): 270-279., articleTitle=Porcine reproductive and respiratory syndrome virus non-structural protein 1 suppresses tumor necrosis factor-alpha promoter activation by inhibiting NF-κB and Sp1, refAbstract=null)], funds=[Fund(id=1226592766784877241, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, awardId=21322912D, language=EN, fundingSource=Key Research and Development Program of Hebei Province(21322912D), fundOrder=null, country=null), Fund(id=1226592766898123459, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, awardId=21322912D, language=CN, fundingSource=河北省重点研发计划(21322912D), fundOrder=null, country=null), Fund(id=1226592766990398151, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, awardId=null, language=EN, fundingSource=Program “Tianchi Talent (Young Doctor)” in Xinjiang Uygur Autonomous Region, fundOrder=null, country=null), Fund(id=1226592768374518478, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, awardId=null, language=CN, fundingSource=新疆维吾尔自治区“天池英才(青年博士)”计划, fundOrder=null, country=null)], companyList=[AuthorCompany(id=1226592753488933061, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, xref=1., ext=[AuthorCompanyExt(id=1226592753505710280, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, companyId=1226592753488933061, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.College of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, China), AuthorCompanyExt(id=1226592753518293192, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, companyId=1226592753488933061, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^1.石河子大学 动物科技学院，新疆 石河子)]), AuthorCompany(id=1226592754877247700, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, xref=2., ext=[AuthorCompanyExt(id=1226592754881442006, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, companyId=1226592754877247700, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.Collaborative Innovation Center for Sheep Health Breeding and Zoonotic Disease Prevention and Control, Shihezi University, Shihezi, Xinjiang, China), AuthorCompanyExt(id=1226592754889830616, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, companyId=1226592754877247700, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^2.石河子大学，绵羊健康养殖与人兽共患病防控协同创新中心，新疆 石河子)]), AuthorCompany(id=1226592754998882528, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, xref=3., ext=[AuthorCompanyExt(id=1226592755007271135, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, companyId=1226592754998882528, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^3.International Joint Research Center for Animal Health, Shihezi University, Shihezi, Xinjiang, China), AuthorCompanyExt(id=1226592755032436961, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, companyId=1226592754998882528, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=^3.石河子大学，动物健康养殖国际联合研究中心，新疆 石河子)])], figs=[ArticleFig(id=1226592760979960381, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, language=EN, label=Figure 1, caption=Structure prediction of NSP1 protein. A: NSP1 protein secondary structure prediction by PSIRPED; B: NSP1 protein secondary structure prediction by SOPMA; C: NSP1α tertiary structure prediction; D: NSP1α tertiary structure Rush diagram; E: NSP1β tertiary structure prediction; F: NSP1β tertiary structure rush diagram; G: Tertiary structure model of NSP1 after the combination of two separate subunits; H: Tertiary structure model of whole protein amino acid sequence prediction; I: Molecular docking simulation., figureFileSmall=w1jBRrRe/rf8vkko5/qm1A==, figureFileBig=c0N60zioFLFIv0koTAlEGw==, tableContent=null), ArticleFig(id=1226592761122566725, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, language=CN, label=图1, caption=NSP1蛋白的结构预测。A：PSIPRED预测NSP1蛋白二级结构结果；B：SOPMA预测NSP1蛋白二级结构结果；C：NSP1α三级结构模型；D：NSP1α三级结构拉什图；E：NSP1β三级结构模型；F：NSP1β三级结构拉什图；G：NSP1两个单独亚基结合后的三级结构模型；H：全蛋白氨基酸序列预测的三级结构模型；I：分子对接模拟。, figureFileSmall=w1jBRrRe/rf8vkko5/qm1A==, figureFileBig=c0N60zioFLFIv0koTAlEGw==, tableContent=null), ArticleFig(id=1226592761256784461, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, language=EN, label=Figure 2, caption=Double digestion identification of recombinant plasmid. Lane M: 15 kb DNA marker; Lane 1: Double cut plasmid; Lane 2: Uncut plasmid., figureFileSmall=IaGMkJYw5xBKbEyCX8JrGA==, figureFileBig=gHY7eISpBWOrRbT+V0iFLg==, tableContent=null), ArticleFig(id=1226592761382613588, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, language=CN, label=图2, caption=重组质粒的双酶切鉴定。泳道M：15 kb DNA marker；泳道1：双酶切质粒；泳道2：未酶切质粒。, figureFileSmall=IaGMkJYw5xBKbEyCX8JrGA==, figureFileBig=gHY7eISpBWOrRbT+V0iFLg==, tableContent=null), ArticleFig(id=1226592761508442715, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, language=EN, label=Figure 3, caption=In vitro expression and immunogenicity identification of recombinant protein NSP1. A: Optimization of expression conditions of recombinant protein (lanes 1‒4: The bacterial solution collected at 0 h, 2 h, 4 h and 6 h was induced by 37 ℃, respectively; Lane 5: The bacterial solution collected at 12 h was induced by 16 ℃; B: Reaction of recombinant protein NSP1 with His labeled antibody; C: Reaction of recombinant protein NSP1 with positive serum., figureFileSmall=C++9CwJDEeTw2bDU6GLu1g==, figureFileBig=U9vTmEQQAudiodDntMJ+RQ==, tableContent=null), ArticleFig(id=1226592761638466144, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, language=CN, label=图3, caption=重组蛋白NSP1的体外表达与免疫原性鉴定。A：重组蛋白表达条件的优化(泳道1‒4：分别为37 ℃诱导0、2、4、6 h收集的菌液沉淀；泳道5：16 ℃诱导12 h收集的菌液沉淀)；B：重组蛋白NSP1与His标签抗体的反应；C：重组蛋白NSP1与阳性血清的反应。, figureFileSmall=C++9CwJDEeTw2bDU6GLu1g==, figureFileBig=U9vTmEQQAudiodDntMJ+RQ==, tableContent=null), ArticleFig(id=1226592761772683876, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, language=EN, label=Figure 4, caption=Safety evaluation of mice after immunization. A: The weight change of mice within 7 days after first immunization; B: Changes of body weight in mice within 7 days after second immunization., figureFileSmall=uUyq+z41Ivwye1XXvEhgog==, figureFileBig=r730YNO0xTdr/s5K7gtqsQ==, tableContent=null), ArticleFig(id=1226592761894318697, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, language=CN, label=图4, caption=免疫小鼠后的安全性评价。A：小鼠首次免疫后7 d内体重变化；B：小鼠二次免疫后7 d内体重变化。, figureFileSmall=uUyq+z41Ivwye1XXvEhgog==, figureFileBig=r730YNO0xTdr/s5K7gtqsQ==, tableContent=null), ArticleFig(id=1226592761994981999, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, language=EN, label=Figure 5, caption=Expression of cytokines in serum and spleen lymphocytes of mice. A: Expression of cytokine mRNA in spleen lymphocytes on day 28; B: Expression of cytokine mRNA level in spleen lymphocytes at day 42 standard curve of IL-10 kit standard product; D: Expression level of IL-10 in serum of mice at day 42. ns: P>0.05; *: P<0.05; **: P<0.01; ***: P<0.001; ****: P<0.000 1., figureFileSmall=UoZ0mB6AHmF3QPZNK7Wc0Q==, figureFileBig=1T5ECMwCI2wCwFMVqoSeYg==, tableContent=null), ArticleFig(id=1226592762108228212, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, language=CN, label=图5, caption=小鼠血清及脾脏淋巴细胞中各细胞因子的表达。A：28 d脾脏淋巴细胞中细胞因子mRNA水平的表达；B：42 d脾脏淋巴细胞中细胞因子mRNA水平的表达；C：IL-10试剂盒标准品制作的标准曲线；D：42 d时小鼠血清中IL-10表达水平。, figureFileSmall=UoZ0mB6AHmF3QPZNK7Wc0Q==, figureFileBig=1T5ECMwCI2wCwFMVqoSeYg==, tableContent=null), ArticleFig(id=1226592762208891514, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, language=EN, label=Figure 6, caption=Lymphocyte proliferation activity and IFN-γ expression. A: Elispot result spot map; B: Expression of IFN-γ at day 28; C: The expression of IFN-γ at day 42; D: Lymphocyte proliferation activity at day 28. ns: P>0.05; *: P<0.05; **: P<0.01; ***: P<0.001; ****: P<0.000 1., figureFileSmall=Oq+1VD1QstSet6OWKCm7Hg==, figureFileBig=yOmUpAa8KNxLkW3P9OCfbw==, tableContent=null), ArticleFig(id=1226592762301166209, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, language=CN, label=图6, caption=淋巴细胞增殖活性与IFN-γ的表达。A：Elispot结果斑点图；B：28 d时IFN-γ的表达；C：42 d时IFN-γ的表达；D：28 d时淋巴细胞增殖活性。, figureFileSmall=Oq+1VD1QstSet6OWKCm7Hg==, figureFileBig=yOmUpAa8KNxLkW3P9OCfbw==, tableContent=null), ArticleFig(id=1226592762414412426, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, language=EN, label=Figure 7, caption=Specific antibody levels of recombinant protein NSP1 in mice. A: Specific antibody IgG level; B: Specific antibody IgG1 level; C: Specific antibody IgG2a level., figureFileSmall=4ghIr21veCfRfWM/sk+v3g==, figureFileBig=VvO+nwKpSuAkmaFl359JQQ==, tableContent=null), ArticleFig(id=1226592763794338452, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, language=CN, label=图7, caption=重组蛋白NSP1在小鼠体内的特异性抗体水平。A：特异性抗体IgG水平；B：特异性抗体IgG1水平；C：特异性抗体IgG2a水平。, figureFileSmall=4ghIr21veCfRfWM/sk+v3g==, figureFileBig=VvO+nwKpSuAkmaFl359JQQ==, tableContent=null), ArticleFig(id=1226592765757272727, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, language=EN, label=Figure 8, caption=Ratio of specific antibody subtype IgG2a to IgG1., figureFileSmall=rB+An/y0Ag3/2MA8FIXIEw==, figureFileBig=drKmT/0k3ntqihIUCEe4ig==, tableContent=null), ArticleFig(id=1226592766029902492, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, language=CN, label=图8, caption=特异性抗体亚型IgG2a与IgG1的比值, figureFileSmall=rB+An/y0Ag3/2MA8FIXIEw==, figureFileBig=drKmT/0k3ntqihIUCEe4ig==, tableContent=null), ArticleFig(id=1226592766172508832, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, language=EN, label=Figure 9, caption=Neutralizing antibody levels in mice immunized with recombinant protein NSP1. ns: P>0.05；*: P<0.05., figureFileSmall=zp5zG+vSyEtFNpv/0XFZeg==, figureFileBig=0rSARZEKblJosdk8vUx6Xw==, tableContent=null), ArticleFig(id=1226592766294143652, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, language=CN, label=图9, caption=重组蛋白NSP1免疫小鼠后的中和抗体水平, figureFileSmall=zp5zG+vSyEtFNpv/0XFZeg==, figureFileBig=0rSARZEKblJosdk8vUx6Xw==, tableContent=null), ArticleFig(id=1226592766440944298, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, language=EN, label=Table 1, caption=

Immunization schedule and grouping of mice

, figureFileSmall=null, figureFileBig=null, tableContent=

组别 Group	数目 Number	疫苗 Vaccine	免疫剂量 Immune dose	免疫次数 Immune frequency	免疫周期 Immune cycle
1	12	NSP1	50 μg+50 μL	2	0 d, 14 d
2	12	PBS	100 μL	2	0 d, 14 d
3	12	Vaccines	100 μL	2	0 d, 14 d

), ArticleFig(id=1226592766549996208, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1226236830903877849, language=CN, label=表1, caption=

小鼠免疫计划及分组情况

, figureFileSmall=null, figureFileBig=null, tableContent=

组别 Group	数目 Number	疫苗 Vaccine	免疫剂量 Immune dose	免疫次数 Immune frequency	免疫周期 Immune cycle
1	12	NSP1	50 μg+50 μL	2	0 d, 14 d
2	12	PBS	100 μL	2	0 d, 14 d
3	12	Vaccines	100 μL	2	0 d, 14 d

)], attaches=null, journal=Journal(id=1192105720683257860, delFlag=0, nameCn=微生物学报, nameEn=Acta Microbiologica Sinica, nameHistory1=null, nameHistory2=null, issn=0001-6209, eissn=null, cn=11-1995/Q, coden=null, periodic=0, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=tNA7JigLZj/rxynSmzKgDQ==, journalPrice=null, startedYear=null, abbrevIsoEn=null, journalRemark=null, publicationField=null, createdTime=1762149752067, updatedTime=1762150746905, createdBy=18614031015, updatedBy=13701087609, firstLetterCn=A, firstLetterEn=A, subjectCode=Life Sciences, subjectName=Life Sciences, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=tNA7JigLZj/rxynSmzKgDQ==, picEn=R/d5eSUu8/o5mAGWCF3M5Q==, jcr=null, cjcr=null, exts=[JournalExt(id=1192109893441171829, language=CN, name=微生物学报, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1762150746928, updatedTime=1762150746928, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=https://actamicro.ijournals.cn/actamicrocn/author/login, submissionEditorUrl=https://actamicro.ijournals.cn/actamicrocn/editor/login, submissionReviewUrl=https://actamicro.ijournals.cn/actamicrocn/reviewer/login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1192109893512474998, language=EN, name=Acta Microbiologica Sinica, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1762150746944, updatedTime=1762150746944, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=https://actamicro.ijournals.cn/actamicrocn/author/login, submissionEditorUrl=https://actamicro.ijournals.cn/actamicrocn/editor/login, submissionReviewUrl=https://actamicro.ijournals.cn/actamicrocn/reviewer/login, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1192105938417971205, websiteList=[Website(id=1192106105867223981, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1192105938417971205, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/wswxb/CN, language=CN, createTime=1762149843899, createBy=18614031015, updateTime=1762149888800, updateBy=18614031015, name=微生物学报-中文, tplId=1146099689490845704, title=微生物学报, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1192107120863626198, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1192106105867223981, code=articleTextType, value=kx, createTime=1762150085893, updateTime=1762150085893, creator=18614031015, updator=18614031015), WebsiteProps(id=1192107120834266067, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1192106105867223981, code=banner, value=null, createTime=1762150085886, updateTime=1762150085886, creator=18614031015, updator=18614031015), WebsiteProps(id=1192107120892986329, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1192106105867223981, code=grayFlag, value=0, createTime=1762150085900, updateTime=1762150085900, creator=18614031015, updator=18614031015), WebsiteProps(id=1192107120825877458, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1192106105867223981, code=logo, value=https://castjournals.cast.org.cn/joweb/wswxb/CN/file/pic?fileId=FOz4Ks7dC79FYnCEBIlMdw==, createTime=1762150085884, updateTime=1762150085884, creator=18614031015, updator=18614031015), WebsiteProps(id=1192107120905569243, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1192106105867223981, code=minRunFlag, value=0, createTime=1762150085903, updateTime=1762150085903, creator=18614031015, updator=18614031015), WebsiteProps(id=1192107120846848981, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1192106105867223981, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/wswxb/CN/file/pic, createTime=1762150085889, updateTime=1762150085889, creator=18614031015, updator=18614031015), WebsiteProps(id=1192107120897180634, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1192106105867223981, code=silenceFlag, value=0, createTime=1762150085901, updateTime=1762150085901, creator=18614031015, updator=18614031015), WebsiteProps(id=1192107120842654676, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1192106105867223981, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1762150085888, updateTime=1762150085888, creator=18614031015, updator=18614031015), WebsiteProps(id=1192107120872014807, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1192106105867223981, code=themeColor, value=null, createTime=1762150085895, updateTime=1762150085895, creator=18614031015, updator=18614031015), WebsiteProps(id=1192107120880403416, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1192106105867223981, code=themeStyle, value=null, createTime=1762150085897, updateTime=1762150085897, creator=18614031015, updator=18614031015)]), Website(id=1192106106018218929, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1192105938417971205, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/wswxb/EN, language=EN, createTime=1762149843935, createBy=18614031015, updateTime=1762149925242, updateBy=18614031015, name=微生物学报-英文, tplId=1146101810881728533, title=Acta Microbiologica Sinica, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1192107140455220192, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1192106106018218929, code=articleTextType, value=kx, createTime=1762150090564, updateTime=1762150090564, creator=18614031015, updator=18614031015), WebsiteProps(id=1192107140434248669, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1192106106018218929, code=banner, value=null, createTime=1762150090559, updateTime=1762150090559, creator=18614031015, updator=18614031015), WebsiteProps(id=1192107140476191715, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1192106106018218929, code=grayFlag, value=0, createTime=1762150090569, updateTime=1762150090569, creator=18614031015, updator=18614031015), WebsiteProps(id=1192107140425860060, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1192106106018218929, code=logo, value=https://castjournals.cast.org.cn/joweb/wswxb/EN/file/pic?fileId=FOz4Ks7dC79FYnCEBIlMdw==, createTime=1762150090557, updateTime=1762150090557, creator=18614031015, updator=18614031015), WebsiteProps(id=1192107140484580325, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1192106106018218929, code=minRunFlag, value=0, createTime=1762150090571, updateTime=1762150090571, creator=18614031015, updator=18614031015), WebsiteProps(id=1192107140451025887, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1192106106018218929, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/wswxb/EN/file/pic, createTime=1762150090563, updateTime=1762150090563, creator=18614031015, updator=18614031015), WebsiteProps(id=1192107140480386020, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1192106106018218929, code=silenceFlag, value=0, createTime=1762150090570, updateTime=1762150090570, creator=18614031015, updator=18614031015), WebsiteProps(id=1192107140442637278, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1192106106018218929, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1762150090561, updateTime=1762150090561, creator=18614031015, updator=18614031015), WebsiteProps(id=1192107140463608801, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1192106106018218929, code=themeColor, value=null, createTime=1762150090566, updateTime=1762150090566, creator=18614031015, updator=18614031015), WebsiteProps(id=1192107140467803106, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1192106106018218929, code=themeStyle, value=null, createTime=1762150090567, updateTime=1762150090567, creator=18614031015, updator=18614031015)])], journalTitle=微生物学报, weixinUrl=null, journalUrl=https://actamicro.ijournals.cn, iacademicId=null, status=1, seqNo=null, journalTitleEn=Acta Microbiologica Sinica, journalPhotoCn=tNA7JigLZj/rxynSmzKgDQ==, journalPhotoEn=R/d5eSUu8/o5mAGWCF3M5Q==, journalFirstLetter=A, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false), detailUrlCn=https://castjournals.cast.org.cn/joweb/wswxb/CN/10.13343/j.cnki.wsxb.20240704, detailUrlEn=https://castjournals.cast.org.cn/joweb/wswxb/EN/10.13343/j.cnki.wsxb.20240704, pdfUrlCn=https://castjournals.cast.org.cn/joweb/wswxb/CN/PDF/10.13343/j.cnki.wsxb.20240704, pdfUrlEn=https://castjournals.cast.org.cn/joweb/wswxb/EN/PDF/10.13343/j.cnki.wsxb.20240704, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, reference=null)