Article(id=1194684379487248777, tenantId=1146029695717560320, journalId=1192105938417971205, issueId=1194684377813717012, articleNumber=null, orderNo=null, doi=10.13343/j.cnki.wsxb.20250290, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1744041600000, receivedDateStr=2025-04-08, revisedDate=null, revisedDateStr=null, acceptedDate=1750435200000, acceptedDateStr=2025-06-21, onlineDate=1762764552231, onlineDateStr=2025-11-10, pubDate=1762185600000, pubDateStr=2025-11-04, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1762764552231, onlineIssueDateStr=2025-11-10, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1762764552231, creator=13701087609, updateTime=1762764552231, updator=13701087609, issue=Issue{id=1194684377813717012, tenantId=1146029695717560320, journalId=1192105938417971205, year='2025', volume='65', issue='11', pageStart='4721', pageEnd='5182', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1762764551833, creator=13701087609, updateTime=1762764551833, updator=13701087609, preIssue=null, nextIssue=null, ext=null, issueFiles=null}, startPage=4752, endPage=4762, ext={EN=ArticleExt(id=1194684379671798156, articleId=1194684379487248777, tenantId=1146029695717560320, journalId=1192105938417971205, language=EN, title=Research progress in attack-defense interaction mechanisms between Streptococcus pneumoniae and host autophagy systems, columnId=1192149543727808575, journalTitle=Acta Microbiologica Sinica, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Streptococcus pneumoniae is a common opportunistic pathogen that can cause various infectious diseases, including acute otitis media, bronchitis, sinusitis, community-acquired pneumonia, septicemia, and purulent meningitis. Autophagy, a lysosome-dependent intracellular degradation pathway, plays a dual regulatory role in both bacterial infection and host defense against pathogens. During S. pneumoniae infection, host cells can activate xenophagy to eliminate invading bacteria. However, this pathogen has evolved multiple evasion strategies, such as interfering with autophagosome maturation, escaping autophagic encapsulation, and even hijacking the autophagy pathway to promote intracellular survival and dissemination. Recent years have witnessed significant progress in understanding the molecular mechanisms underlying the dynamic interplay between S. pneumoniae and host autophagy systems during bacterial infection, yet a systematic review synthesizing these findings remains unavailable. This review focuses on the interaction network and key mechanisms of S. pneumoniae with host cell autophagy, aiming to provide theoretical foundations and research perspectives for developing novel targeted therapeutic strategies against S. pneumoniae infections.

, correspAuthors=Yang YANG, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Luqing CUI, Jingyan FAN, Hexiang JIANG, Houhui SONG, Yang YANG), CN=ArticleExt(id=1194684550501605995, articleId=1194684379487248777, tenantId=1146029695717560320, journalId=1192105938417971205, language=CN, title=肺炎链球菌与宿主自噬系统攻防互作机制研究进展, columnId=1192149543882997826, journalTitle=微生物学报, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

肺炎链球菌(Streptococcus pneumoniae)是一种常见的机会致病菌，可引发急性中耳炎、支气管炎、鼻窦炎、社区获得性肺炎、败血症、化脓性脑膜炎等多种感染性疾病。细胞自噬是一种依赖溶酶体的细胞内降解途径，在细菌感染以及宿主防御病原体感染的过程中发挥双重调控作用。在肺炎链球菌感染时可激活宿主细胞的异源自噬(xenophagy)途径，进而促进胞内细菌的清除；然而，该病原体也进化出多种逃逸策略，包括干扰自噬体成熟、逃避自噬体包裹，甚至劫持自噬通路以促进其在胞内的存活和扩散。近年来，关于肺炎链球菌与宿主细胞自噬系统间动态互作的分子机制及其在细菌感染过程中的作用已取得显著进展，但尚无系统性综述对此进行梳理。本文聚焦于肺炎链球菌与宿主细胞自噬的相互作用网络及其关键作用机制，为抗肺炎链球菌感染的新型靶向治疗策略提供了理论依据和研究思路。

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