Article(id=1192149553873825920, tenantId=1146029695717560320, journalId=1192105938417971205, issueId=1192149543010582589, articleNumber=null, orderNo=null, doi=10.13343/j.cnki.wsxb.20250202, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1741968000000, receivedDateStr=2025-03-15, revisedDate=null, revisedDateStr=null, acceptedDate=1747065600000, acceptedDateStr=2025-05-13, onlineDate=1762160202711, onlineDateStr=2025-11-03, pubDate=1756915200000, pubDateStr=2025-09-04, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1762160202711, onlineIssueDateStr=2025-11-03, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1762160202711, creator=13701087609, updateTime=1762160202711, updator=13701087609, issue=Issue{id=1192149543010582589, tenantId=1146029695717560320, journalId=1192105938417971205, year='2025', volume='65', issue='10', pageStart='4241', pageEnd='4713', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1762160200113, creator=13701087609, updateTime=1762160638682, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1192151382586175735, tenantId=1146029695717560320, journalId=1192105938417971205, issueId=1192149543010582589, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1192151382586175736, tenantId=1146029695717560320, journalId=1192105938417971205, issueId=1192149543010582589, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=4295, endPage=4307, ext={EN=ArticleExt(id=1192149554062569602, articleId=1192149553873825920, tenantId=1146029695717560320, journalId=1192105938417971205, language=EN, title=Research progress in the role of gut microbiota in alcoholic liver disease, columnId=1192149543727808575, journalTitle=Acta Microbiologica Sinica, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Alcoholic liver disease (ALD) is a liver disease caused by long-term excessive alcohol consumption and is one of the most common chronic liver diseases worldwide. At present, no effective approach is available for preventing or reversing this disease, causing a serious social burden and increasing the pressure for prevention and treatment. In recent years, researchers have found that long-term alcohol abuse can lead to significant changes in the structure and function of the gut microbiota, thereby disrupting the balance of the gut microbiota, which can promote the progression of ALD. Therefore, maintaining gut microbiota balance can provide new targets for the prevention and treatment of ALD. This article reviews the research and intervention progress of the gut microbiota and its metabolites in ALD in recent years, providing reference for future studies on the pathogenesis and treatment of this disease.

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酒精性肝病(alcoholic liver disease, ALD)是由于长期过量饮酒所致的肝脏疾病，是全球最常见的慢性肝病之一。目前尚无有效治疗方法来阻止或逆转该病，造成了严重的社会负担，其防治压力不断增大。近年来，学者们发现长期酗酒会导致肠道菌群结构和功能的显著改变，从而破坏肠道菌群的平衡，而肠道菌群的失调则会推动酒精性肝病的进展。因此，在一定程度上维持肠道菌群稳态可为该病的预防和治疗提供新的靶点。本文主要综述近年来肠道菌群及其代谢产物与酒精性肝病的研究及干预治疗进展，为今后研究其发病机制及治疗提供参考。

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Clinical observation of taurine compound in the treatment of alcoholic liver disease[D]. Nanning: Guangxi University of Chinese Medicine, 2019 (in Chinese)., articleTitle=null, refAbstract=null), Reference(id=1192160881208344784, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1192149553873825920, doi=null, pmid=null, pmcid=null, year=2021, volume=137, issue=null, pageStart=147, pageEnd=157, url=null, language=null, rfNumber=[70], rfOrder=73, authorNames=RAO JJ, QIAO Y, XIE RN, LIN L, JIANG J, WANG CM, LI GY, journalName=Journal of Psychiatric Research, refType=null, unstructuredReference=RAO JJ, QIAO Y, XIE RN, LIN L, JIANG J, WANG CM, LI GY. Fecal microbiota transplantation ameliorates stress-induced depression-like behaviors associated with the inhibition of glial and NLRP3 inflammasome in rat brain[J]. 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ADH: Alcohol dehydrogenase; ALDH: Aldehyde dehydrogenase; HSC: Hepatic stellate cell., figureFileSmall=JFM83fPOCQSwrukjGBhgtA==, figureFileBig=Ov/y06RZKL+FMwtbliiBtg==, tableContent=null), ArticleFig(id=1192160874002530427, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1192149553873825920, language=CN, label=图1, caption=ALD发病机制, figureFileSmall=JFM83fPOCQSwrukjGBhgtA==, figureFileBig=Ov/y06RZKL+FMwtbliiBtg==, tableContent=null), ArticleFig(id=1192160874094805116, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1192149553873825920, language=EN, label=Figure 2, caption=Possible mechanism of ALD caused by intestinal changes., figureFileSmall=KjnGN+WNVnp8m0S1Nos/aw==, figureFileBig=8dN7h3C1MCxpVKqP9G0bKw==, tableContent=null), ArticleFig(id=1192160874149331069, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1192149553873825920, language=CN, label=图2, caption=肠道变化引发ALD的可能机制, figureFileSmall=KjnGN+WNVnp8m0S1Nos/aw==, figureFileBig=8dN7h3C1MCxpVKqP9G0bKw==, tableContent=null), ArticleFig(id=1192160874208051326, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1192149553873825920, language=EN, label=Figure 3, caption=Interactive network diagram of the “microbiota bile acid host signaling axis”. 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Changes of gut microbiota in ALD patients

, figureFileSmall=null, figureFileBig=null, tableContent=

No.	Participant (n)	Changes in intestinal bacteria or fungi in ALD patients	References
1	Alcoholic hepatitis with bilirubin higher than 14.1 mg/dL (36) vs. alcoholic hepatitis with bilirubin less or equal 14.1 mg/dL (37)	↑Veillonella, ↑Enterococcus, ↓Akkermansia	[14]
2	Healthy control (11) vs. patients with AUD (42) vs. patients with AH (91)	↑Candidalysin-positive, ↑Candida albicans	[19]
3	ALC (13) vs. alcoholics without cirrhosis (15) vs. non-alcoholic control (14)	↑Gram-negative Bacteroides spp., ↑Gram-negative Enterobacteriaceae, ↑Gram-negative Enterobacter spp.	[20]
4	Healthy controls (14) vs. patients with AUD (43) vs. patients with AH (75)	↑Enterococcus faecalis	[21]
5	ALC with active alcohol misuse (37) vs. abstinent cirrhotic patients (68) vs. healthy controls (34)	↑Pseudomonadota (Enterobacteriaceae),↓Lachnospiraceae, ↓Bacteroidaceae, ↓Prevotellaceae	[22]
6	AFL patients (21) vs. ALC patients (17) vs. healthy controls (27)	↓Opitutales, ↓Helotiales, ↓Ophiostomatales, ↑Pseudomonadota, ↓Ruminococcaceae, ↑Fusobacteria, ↓Faecalibacterium, ↑Fusobacteriaceae, ↓Lachnospira, ↑Enterobacteriaceae, ↓Agathobacter, ↑Burkholderiaceae, ↓Ruminococcus, ↑Fusobacterium, ↑Escherichia-Shigella	[23]
7	Severe alcoholic hepatitis (24) vs. healthy controls (24)	↓Bacteroidetes, ↓Verrucomicrobia, ↑Fusobacteria, ↑Bacillota/Bacteroidetesratio, ↑Veillonella, ↓Eubacterium-g23	[24]
8	Alcohol use disorder (36) vs. controls (36)	↑Sutterella, Haemophilus, ↑Staphylococcus, ↑Paraprevotella, ↑Eubacterium, ↑Streptococcus, ↑Odoribacter, ↑Veillonella, ↑Enterococcus, ↑Lactobacillus el at. ↓Akkermansia, ↓Blautia, ↓Bifidobacterium, ↓Coprococcus, ↓Dorea, ↓Anaerostipes, ↓Adlercreutzia, ↓Ruminococcus	[25]
9	Alcohol use disorder (66) vs. control subjects (18)	↑Candida, ↑Debaryomyces, ↑Pichia, ↑Kluyveromyces, ↑ Issatchenkia, ↑Scopulariopsis, ↑Candida albicans, ↑Candida zeylanoides, ↑Issatchenkia orientalis, ↑Scopulariopsis cordiae, ↓Aspergillus, ↓Kazachstania humilis	[26]

), ArticleFig(id=1192160874367434881, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1192149553873825920, language=CN, label=表1, caption=

ALD患者肠道菌群变化

, figureFileSmall=null, figureFileBig=null, tableContent=

No.	Participant (n)	Changes in intestinal bacteria or fungi in ALD patients	References
1	Alcoholic hepatitis with bilirubin higher than 14.1 mg/dL (36) vs. alcoholic hepatitis with bilirubin less or equal 14.1 mg/dL (37)	↑Veillonella, ↑Enterococcus, ↓Akkermansia	[14]
2	Healthy control (11) vs. patients with AUD (42) vs. patients with AH (91)	↑Candidalysin-positive, ↑Candida albicans	[19]
3	ALC (13) vs. alcoholics without cirrhosis (15) vs. non-alcoholic control (14)	↑Gram-negative Bacteroides spp., ↑Gram-negative Enterobacteriaceae, ↑Gram-negative Enterobacter spp.	[20]
4	Healthy controls (14) vs. patients with AUD (43) vs. patients with AH (75)	↑Enterococcus faecalis	[21]
5	ALC with active alcohol misuse (37) vs. abstinent cirrhotic patients (68) vs. healthy controls (34)	↑Pseudomonadota (Enterobacteriaceae),↓Lachnospiraceae, ↓Bacteroidaceae, ↓Prevotellaceae	[22]
6	AFL patients (21) vs. ALC patients (17) vs. healthy controls (27)	↓Opitutales, ↓Helotiales, ↓Ophiostomatales, ↑Pseudomonadota, ↓Ruminococcaceae, ↑Fusobacteria, ↓Faecalibacterium, ↑Fusobacteriaceae, ↓Lachnospira, ↑Enterobacteriaceae, ↓Agathobacter, ↑Burkholderiaceae, ↓Ruminococcus, ↑Fusobacterium, ↑Escherichia-Shigella	[23]
7	Severe alcoholic hepatitis (24) vs. healthy controls (24)	↓Bacteroidetes, ↓Verrucomicrobia, ↑Fusobacteria, ↑Bacillota/Bacteroidetesratio, ↑Veillonella, ↓Eubacterium-g23	[24]
8	Alcohol use disorder (36) vs. controls (36)	↑Sutterella, Haemophilus, ↑Staphylococcus, ↑Paraprevotella, ↑Eubacterium, ↑Streptococcus, ↑Odoribacter, ↑Veillonella, ↑Enterococcus, ↑Lactobacillus el at. ↓Akkermansia, ↓Blautia, ↓Bifidobacterium, ↓Coprococcus, ↓Dorea, ↓Anaerostipes, ↓Adlercreutzia, ↓Ruminococcus	[25]
9	Alcohol use disorder (66) vs. control subjects (18)	↑Candida, ↑Debaryomyces, ↑Pichia, ↑Kluyveromyces, ↑ Issatchenkia, ↑Scopulariopsis, ↑Candida albicans, ↑Candida zeylanoides, ↑Issatchenkia orientalis, ↑Scopulariopsis cordiae, ↓Aspergillus, ↓Kazachstania humilis	[26]

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