Article(id=1192149553483755643, tenantId=1146029695717560320, journalId=1192105938417971205, issueId=1192149543010582589, articleNumber=null, orderNo=null, doi=10.13343/j.cnki.wsxb.20250151, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1740585600000, receivedDateStr=2025-02-27, revisedDate=null, revisedDateStr=null, acceptedDate=1746460800000, acceptedDateStr=2025-05-06, onlineDate=1762160202618, onlineDateStr=2025-11-03, pubDate=1756915200000, pubDateStr=2025-09-04, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1762160202618, onlineIssueDateStr=2025-11-03, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1762160202618, creator=13701087609, updateTime=1762160202618, updator=13701087609, issue=Issue{id=1192149543010582589, tenantId=1146029695717560320, journalId=1192105938417971205, year='2025', volume='65', issue='10', pageStart='4241', pageEnd='4713', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1762160200113, creator=13701087609, updateTime=1762160638682, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1192151382586175735, tenantId=1146029695717560320, journalId=1192105938417971205, issueId=1192149543010582589, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1192151382586175736, tenantId=1146029695717560320, journalId=1192105938417971205, issueId=1192149543010582589, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=4406, endPage=4419, ext={EN=ArticleExt(id=1192149553664110718, articleId=1192149553483755643, tenantId=1146029695717560320, journalId=1192105938417971205, language=EN, title=Isolation, identification, and phylogenetic analysis of porcine circovirus type 3c (HK strain), columnId=1192149543992045670, journalTitle=Acta Microbiologica Sinica, columnName=Research Article, runingTitle=null, highlight=null, articleAbstract=

[Objective] Porcine circovirus type 3 (PCV3) is associated with the development of reproductive disorders in sows, piglet dermatitis, and myocarditis. However, due to the difficulty in stably passaging PCV3 in vitro, the animal infection model construction and specific pathogenicity of PCV3 remain to be investigated. This study aims to solve the above problems. [Methods] A PCV3 strain (PCV3-HK) was successfully isolated by inoculating PK-15 cells with lymph node samples from PCV3-positive weaned piglets. The strain was identified using PCR, indirect immunofluorescence assay, and transmission electron microscopy, and its complete genome was sequenced. The whole genome of the strain was sequenced. The pathogenicity of the strain was evaluated based on the clinical symptoms, body weight changes, virus excretion, and pathological changes of 21-day-old non-weaned piglets after inoculation with the 15th-passage viral cell culture at a dose of 10^6.4 TCID₅₀/mL. [Results] PCV3-HK had a genome length of 2 000 bp and belonged to PCV3c subtype. The viral particles were spherical, non-enveloped, about 15-20 nm in diameter, and capable of reacting specifically with the monoclonal antibody against PCV3 Cap protein. The results of infection in piglets showed that the PCV3-HK infected pigs developed obvious symptoms such as dermatitis, slow weight gain and even wasting, as well as anatomical changes such as lymph node edema and interstitial pneumonia. The viral nucleic acid was detected in oral swabs and anal swabs on day 7-21 post infection, and viremia was observed. The virus infected multiple organs, including the heart, lungs, kidneys, and lymph nodes. Notably, inflammatory cell infiltration and aggregation of necrotic cells were observed in the kidneys and lymph nodes. [Conclusion] We isolate a PCV3 strain with classical circovirus morphology and establish a piglet infection model, which provides key materials for pathogenic mechanism study and vaccine development regarding PCV3.

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【目的】 猪圆环病毒3型(porcine circovirus type 3, PCV3)与母猪繁殖障碍、仔猪皮炎及心肌炎等疾病的发生密切相关。病毒在细胞上难以稳定传代，阻碍了PCV3动物感染模型的构建及其致病性的研究。 【方法】 利用PCV3阳性断奶仔猪的淋巴结病料接种PK-15细胞进行病毒分离，通过PCR、间接免疫荧光试验和透射电镜观察等方法对毒株进行鉴定，成功分离到一株PCV3毒株(PCV3-HK株)，并测定了该毒株的全基因组。使用毒价为10^6.4 TCID₅₀/mL的第15代病毒细胞培养物在接种21日龄未断奶仔猪，通过临床症状、体重变化、排毒情况和病理变化等评价该毒株的致病性。 【结果】 病毒分离鉴定结果表明，PCV3-HK株基因组全长2 000 bp，属于PCV3c基因亚型，病毒粒子为圆球形、无囊膜、直径约15-20 nm的颗粒，能够与PCV3 Cap蛋白单克隆抗体发生特异性反应；仔猪感染试验结果显示，PCV3-HK株感染猪出现皮炎、增重缓慢甚至消瘦等症状，以及淋巴结水肿、间质性肺炎等剖检变化；在感染的第7-21天，口拭子和肛拭子中均可检测到病毒核酸，并出现病毒血症。该病毒感染仔猪的心、肺、肾和淋巴结等器官，尤其在肾脏和淋巴结中观察到炎性细胞浸润、坏死细胞聚集等病理变化。 【结论】 本研究分离到一株PCV3c毒株，建立了仔猪感染模型，为PCV3致病机制研究和疫苗研发提供了关键材料。

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Isolation and pathogenicity analysis of porcine circovirus type 3[J]. 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Primers for PCV3 detection, genome sequencing and qPCR primers

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实验目的 Objective	引物名称 Primers name	引物序列 Primer sequences (5′－3′)	产物长度 Product length (bp)
病毒检测 Virus detection	PCV3-F	TTAGAGAACGGACTTGTAACGAATCCA	645
	PCV3-R	ATGAGACACAGAGCTATATTCAGAAGAAGAC
全基因组扩增 Whole genome amplification	PCV3-F1	TAGTATTACCCGGCACCTCGGAACC	1 257
	PCV3-R1	ACAGGTAAACGCCCTCGCATGTGGG
	PCV3-F2	TTGCACTTGTGTACAATTATTGCG	1 075
	PCV3-R2	ATCTTCAGGACACTCGTAGCACCAC
PCV3定量PCR检测 Quantitative PCR detection of PCV3	PCV3-qF	TAAACGAATGGGAAACTGCC	179
	PCV3-qR	TTCCGCATAAGGGTCGTCT
	PCV3-Probe	CACTCAGCCCTGTAAT

), ArticleFig(id=1192161171315765586, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1192149553483755643, language=CN, label=表1, caption=

PCV3检测、全基因组测序及荧光定量PCR引物

, figureFileSmall=null, figureFileBig=null, tableContent=

实验目的 Objective	引物名称 Primers name	引物序列 Primer sequences (5′－3′)	产物长度 Product length (bp)
病毒检测 Virus detection	PCV3-F	TTAGAGAACGGACTTGTAACGAATCCA	645
	PCV3-R	ATGAGACACAGAGCTATATTCAGAAGAAGAC
全基因组扩增 Whole genome amplification	PCV3-F1	TAGTATTACCCGGCACCTCGGAACC	1 257
	PCV3-R1	ACAGGTAAACGCCCTCGCATGTGGG
	PCV3-F2	TTGCACTTGTGTACAATTATTGCG	1 075
	PCV3-R2	ATCTTCAGGACACTCGTAGCACCAC
PCV3定量PCR检测 Quantitative PCR detection of PCV3	PCV3-qF	TAAACGAATGGGAAACTGCC	179
	PCV3-qR	TTCCGCATAAGGGTCGTCT
	PCV3-Probe	CACTCAGCCCTGTAAT

), ArticleFig(id=1192161171374485844, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1192149553483755643, language=EN, label=Table 2, caption=

Information of PCV3 reference strains

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GenBank登录号 GenBank accession number	来源 Origins	毒株名称 Strain name	分离年 Separatist year	基因亚型 Genotype
NC031753	美国USA	29160/2018/PCV3a	2018	PCV3a
MN698795	韩国Korea	K-2010-1/2010/PCV3a	2010	PCV3a
KY996338	韩国Korea	KU-1602/2016/PCV3a	2016	PCV3a
MF611876	韩国Korea	1701/2016/PCV3a	2016	PCV3a
MN725087	马来西亚Malaysia	KG194L/UPM/MY015/2020/PCV3a	2020	PCV3a
MH603543	美国USA	KSU-IA-2017-PCV3-27/2016/PCV3a	2016	PCV3a
MG870103	中国China	PCV3-China/JL17-45/2018/PCV3a	2018	PCV3a
MW167063	西班牙Spain	PCV3-52/2020/PCV3a	2020	PCV3a
OQ469802	中国China	SDAU-HZ/2023/PCV3a	2023	PCV3a
MF769805	中国China	Pig/CN/Hebei/2017/PCV3a	2017	PCV3a
MF589107	中国China	CN/Jiangxi-B1/2017/PCV3a	2018	PCV3a
MZ890322	加拿大Canada	70-0004/2021/ON/2023/PCV3a	2023	PCV3a
MG372483	中国China	CN/Heilongjiang/2017/PCV3a	2017	PCV3a
KY421347	中国China	CHN/GD/2016/PCV3a	2016	PCV3a
MG727539	中国China	PCV3/CH/HB/CZ-1/2017/PCV3a	2017	PCV3a
MF084994	中国China	CN/Anhui-14/2016/PCV3a	2016	PCV3a
MF162298	意大利Italy	IT/CO/2017/PCV3c	2017	PCV3c
MF069116	中国China	CN/GDHE2/2016/PCV3c	2016	PCV3c
MG250179	中国China	GXNN2016-4/2016/PCV3c	2016	PCV3c
MF677835	中国China	JX-1/CH/2016/PCV3c	2016	PCV3c
OP948027	中国China	CN-LuZhou/2023/PCV3c	2023	PCV3c
MG868941	中国China	HBWH-201703/2017/PCV3c	2017	PCV3c
MK580468	中国China	CN-Nanjing/2017/PCV3c	2017	PCV3c
MG250176	中国China	GXYL2009-1/2017/PCV3c	2017	PCV3c
MH491016	中国China	GDDH1/2018/PCV3c	2018	PCV3c
MG372488	中国China	CN/Hunan/2/2006/PCV3b	2006	PCV3b
MG372490	中国China	CN/Hunan/1/2006/PCV3b	2006	PCV3b

), ArticleFig(id=1192161171445789014, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1192149553483755643, language=CN, label=表2, caption=

PCV3参考毒株信息

, figureFileSmall=null, figureFileBig=null, tableContent=

GenBank登录号 GenBank accession number	来源 Origins	毒株名称 Strain name	分离年 Separatist year	基因亚型 Genotype
NC031753	美国USA	29160/2018/PCV3a	2018	PCV3a
MN698795	韩国Korea	K-2010-1/2010/PCV3a	2010	PCV3a
KY996338	韩国Korea	KU-1602/2016/PCV3a	2016	PCV3a
MF611876	韩国Korea	1701/2016/PCV3a	2016	PCV3a
MN725087	马来西亚Malaysia	KG194L/UPM/MY015/2020/PCV3a	2020	PCV3a
MH603543	美国USA	KSU-IA-2017-PCV3-27/2016/PCV3a	2016	PCV3a
MG870103	中国China	PCV3-China/JL17-45/2018/PCV3a	2018	PCV3a
MW167063	西班牙Spain	PCV3-52/2020/PCV3a	2020	PCV3a
OQ469802	中国China	SDAU-HZ/2023/PCV3a	2023	PCV3a
MF769805	中国China	Pig/CN/Hebei/2017/PCV3a	2017	PCV3a
MF589107	中国China	CN/Jiangxi-B1/2017/PCV3a	2018	PCV3a
MZ890322	加拿大Canada	70-0004/2021/ON/2023/PCV3a	2023	PCV3a
MG372483	中国China	CN/Heilongjiang/2017/PCV3a	2017	PCV3a
KY421347	中国China	CHN/GD/2016/PCV3a	2016	PCV3a
MG727539	中国China	PCV3/CH/HB/CZ-1/2017/PCV3a	2017	PCV3a
MF084994	中国China	CN/Anhui-14/2016/PCV3a	2016	PCV3a
MF162298	意大利Italy	IT/CO/2017/PCV3c	2017	PCV3c
MF069116	中国China	CN/GDHE2/2016/PCV3c	2016	PCV3c
MG250179	中国China	GXNN2016-4/2016/PCV3c	2016	PCV3c
MF677835	中国China	JX-1/CH/2016/PCV3c	2016	PCV3c
OP948027	中国China	CN-LuZhou/2023/PCV3c	2023	PCV3c
MG868941	中国China	HBWH-201703/2017/PCV3c	2017	PCV3c
MK580468	中国China	CN-Nanjing/2017/PCV3c	2017	PCV3c
MG250176	中国China	GXYL2009-1/2017/PCV3c	2017	PCV3c
MH491016	中国China	GDDH1/2018/PCV3c	2018	PCV3c
MG372488	中国China	CN/Hunan/2/2006/PCV3b	2006	PCV3b
MG372490	中国China	CN/Hunan/1/2006/PCV3b	2006	PCV3b

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