Article(id=1316714709223592235, tenantId=1146029695717560320, journalId=1192105938417971205, issueId=1316714454184739470, articleNumber=null, orderNo=null, doi=10.13343/j.cnki.wsxb.20260440, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1779638400000, receivedDateStr=2026-05-25, revisedDate=null, revisedDateStr=null, acceptedDate=1783008000000, acceptedDateStr=2026-07-03, onlineDate=1791858850055, onlineDateStr=2026-10-13, pubDate=1791043200000, pubDateStr=2026-10-04, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1791858850055, onlineIssueDateStr=2026-10-13, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1791858850055, creator=13701087609, updateTime=1791858850055, updator=13701087609, issue=Issue{id=1316714454184739470, tenantId=1146029695717560320, journalId=1192105938417971205, year='2026', volume='66', issue='10', pageStart='4661', pageEnd='5310', issueExtLink='null', onlineDate='null', pubDate='1791043200000', pubDateStr='2026-10-04', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1791858789249, creator='13701087609', updateTime=1791885400527, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1316826070066774161, tenantId=1146029695717560320, journalId=1192105938417971205, issueId=1316714454184739470, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1316826070066774162, tenantId=1146029695717560320, journalId=1192105938417971205, issueId=1316714454184739470, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=5223, endPage=5236, ext={EN=ArticleExt(id=1316714710431551790, articleId=1316714709223592235, tenantId=1146029695717560320, journalId=1192105938417971205, language=EN, title=Shouwu Pill ameliorates doxorubicin-induced premature aging by modulating gut microbiota and bile acid metabolism in mice, columnId=1192149543992045670, journalTitle=Acta Microbiologica Sinica, columnName=Research Article, runingTitle=null, highlight=null, articleAbstract=

[Objective] To investigate the effects of Shouwu Pill (SWW) on physical performance, gut microbiota composition, and bile acid metabolism in the mouse model of doxorubicin (DOXO)-induced premature aging, and to preliminarily explore its potential mechanisms. [Methods] A mouse model of premature aging was established by intraperitoneal injection of DOXO. Mice were randomized into Control, DOXO, DOXO+Shouwu Pill low-dose (SWW-L), and DOXO+Shouwu Pill high-dose (SWW-H) groups. Grip strength test, hanging endurance test, and treadmill exercise test were performed to evaluate physical performance. Gut microbiota composition and diversity were analyzed by 16S rRNA gene sequencing, followed by PICRUSt functional prediction. Fecal bile acid profiling was performed via UHPLC-QQQ-MS. Spearman correlation analysis was further conducted to explore the association between differentially abundant gut microbial taxa and bile acid metabolism. [Results] Compared with the Control group, DOXO-treated mice exhibited increased systemic inflammatory cytokine levels and significantly decreased forelimb grip strength, hanging endurance, and maximal running speed, indicating successful establishment of the premature aging model. SWW treatment significantly reduced systemic inflammation and improved physical performance, with the DOXO+SWW-H group demonstrating greater efficacy than the DOXO+SWW-L group. The results of 16S rRNA gene sequencing revealed that DOXO induced gut microbiota dysbiosis characterized by altered microbial diversity and disrupted microbiota structure, including decreased abundance of Muribaculaceae and increased abundance of opportunistic pathogenic genera such as Desulfovibrio and Helicobacter. SWW treatment partially restored the microbiota structure by increasing the abundance of potentially beneficial bacteria, including Akkermansia, Lactobacillus, Bifidobacterium, and Roseburia. PICRUSt functional prediction indicated significant alterations in bile acid metabolism-related pathways following SWW intervention. Fecal bile acid profiling further demonstrated that DOXO treatment led to the accumulation of several conjugated bile acids, including T-α-MCA and T-β-MCA, accompanied by reduced levels of unconjugated bile acids. SWW intervention significantly lowered the levels of conjugated bile acids and partially restored the levels of unconjugated bile acids. Correlation analysis showed that several beneficial bacteria were positively correlated with unconjugated bile acids but negatively correlated with conjugated bile acids. [Conclusion] SWW ameliorates physical decline and gut microbiota dysbiosis in the mouse model of DOXO-induced premature aging. Its anti-aging effects may be associated with modulation of gut microbiota-related bile acid metabolism and restoration of bile acid homeostasis.

, authors=Bingbing FENG^{1, 2}, Zheng CAO^{1, 2}, Yao YI^{1, 2}, Jing LI^{1, *}, authorsList=Bingbing FENG, Zheng CAO, Yao YI, Jing LI, authorCompany=null, correspAuthors=Jing LI, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1316714711547236664, articleId=1316714709223592235, tenantId=1146029695717560320, journalId=1192105938417971205, language=CN, title=首乌丸对阿霉素诱导的早衰小鼠生理功能和肠道微生物的影响, columnId=1192149544164012138, journalTitle=微生物学报, columnName=研究报告, runingTitle=null, highlight=null, articleAbstract=

【目的】 探讨首乌丸对阿霉素(doxorubicin, DOXO)诱导早衰小鼠运动能力、肠道菌群及胆汁酸代谢的影响，并初步阐明其潜在作用机制。 【方法】 小鼠随机分为Control组、DOXO组、首乌丸低剂量组(Shouwu Pill low-dose, SWW-L)及首乌丸高剂量组(Shouwu Pill high-dose, SWW-H)；除Control组外，其余各组采用DOXO腹腔注射建立早衰小鼠模型。通过前肢握力实验、悬挂网实验及跑台实验评价小鼠运动能力变化；采用16S rRNA基因测序分析肠道菌群结构及多样性变化，并结合PICRUSt进行菌群功能预测；采用UHPLC-QQQ-MS检测粪便胆汁酸谱变化；进一步通过Spearman相关性分析探讨差异菌群与胆汁酸代谢之间的关系。 【结果】 与Control组相比，DOXO组小鼠血清炎症因子水平升高，握力、悬挂耐力及最大跑步速度显著下降，提示早衰模型构建成功；首乌丸干预后，血清炎症因子水平降低，上述运动能力指标明显改善，其中高剂量组效果更为显著。16S rRNA基因测序结果显示，DOXO诱导小鼠肠道菌群失衡，表现为菌群多样性改变及群落结构紊乱，鼠杆状菌属(Muribaculaceae_unclassified)等优势菌丰度下降，而脱硫弧菌属(Desulfovibrio)、Helicobacter等条件致病菌相对丰度升高；首乌丸干预后，阿克曼氏菌属(Akkermansia)、乳杆菌属(Lactobacillus)、双歧杆菌属(Bifidobacterium)及罗斯拜瑞氏菌属(Roseburia)等潜在有益菌丰度增加，菌群结构逐渐恢复。PICRUSt功能预测显示，首乌丸显著调节胆汁酸代谢相关通路。胆汁酸谱分析结果表明，DOXO组多种结合型胆汁酸(如T-α-MCA、T-β-MCA)显著积累，而部分非结合型胆汁酸水平下降；首乌丸干预后，结合型胆汁酸明显下降，非结合型胆汁酸水平部分恢复。相关性分析显示，多种有益菌与非结合型胆汁酸呈正相关，而与结合型胆汁酸呈负相关。 【结论】 首乌丸能够改善DOXO诱导的早衰小鼠运动功能下降及肠道菌群失衡，并可能通过调节肠道菌群相关胆汁酸代谢恢复胆汁酸稳态，从而发挥延缓早衰的作用。

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A: Experimental design [Premature aging was induced by intraperitoneal injection of doxorubicin (DOXO, 10 mg/kg) on day 0 and 10. Shouwu Pill was administered daily by gavage at low dose (200 mg/kg) or high dose (400 mg/kg) throughout the experimental period]; B: Serum tumor necrosis factor-α (TNF-α) levels in each group (n=6 per group); C: Serum interleukin-1β (IL-1β) levels in each group (n=6 per group); D: Hanging endurance time in each group (n=6 per group); E: Maximal running speed in each group (n=6 per group); F: Forelimb grip strength in each group (n=6 per group). Data are presented as mean±SD. ns: P≥0.05; *: P<0.05; **: P<0.01; ***: P<0.001., figureFileSmall=w7/+XGq5luOoSYDr/f16+Q==, figureFileBig=3fPJrNvBKOeWKf3Au9K3aQ==, tableContent=null), ArticleFig(id=1316829969800614511, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1316714709223592235, language=CN, label=图1, caption=首乌丸改善DOXO诱导早衰小鼠的衰老表型, figureFileSmall=w7/+XGq5luOoSYDr/f16+Q==, figureFileBig=3fPJrNvBKOeWKf3Au9K3aQ==, tableContent=null), ArticleFig(id=1316829969918055024, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1316714709223592235, language=EN, label=Figure 2, caption=Shouwu Pill ameliorates DOXO-induced gut microbiota dysbiosis (n=6 per group). A, B: Alpha diversity analysis of gut microbiota in each group, including Chao1 and Simpson indices; C: Principal coordinates analysis (PCoA) based on Bray-Curtis distances showing differences in microbial beta diversity among groups; D: Relative abundance of gut microbiota at the phylum level; E: Relative abundance of gut microbiota at the genus level. Data are presented as mean±SD. ns: P≥0.05; *: P<0.05; **: P<0.01; ***: P<0.001., figureFileSmall=umZHbT7qrbRFAgnl0sw7tg==, figureFileBig=4D+b9NBOcoy/AAsZqJB6Lg==, tableContent=null), ArticleFig(id=1316829969997746801, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1316714709223592235, language=CN, label=图2, caption=首乌丸改善DOXO诱导的肠道菌群稳态, figureFileSmall=umZHbT7qrbRFAgnl0sw7tg==, figureFileBig=4D+b9NBOcoy/AAsZqJB6Lg==, tableContent=null), ArticleFig(id=1316829970073244274, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1316714709223592235, language=EN, label=Figure 3, caption=Shouwu Pill modulates gut microbiota-associated metabolic functions and bile acid homeostasis in premature aging mice. A: PICRUSt functional prediction analysis based on 16S rRNA gene sequencing showing significantly altered microbial functional pathways in the DOXO+SWW-H group compared with the DOXO group (Colors indicate different functional categories, and the x-axis represents -log₁₀P); B: Fecal concentrations of conjugated bile acids, including primary and secondary bile acids, in each group (n=6 per group); C: Fecal concentrations of unconjugated bile acids, including primary and secondary bile acids, in each group (n=6 per group). Data are presented as mean±SD. *: P<0.05; **: P<0.01, ***: P<0.001., figureFileSmall=xegqvTrDUyqgYPHW8+zejg==, figureFileBig=GLulxMKcP1vVNdzF3sxq+Q==, tableContent=null), ArticleFig(id=1316829970140353139, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1316714709223592235, language=CN, label=图3, caption=首乌丸调控早衰小鼠肠道菌群相关代谢功能及胆汁酸稳态, figureFileSmall=xegqvTrDUyqgYPHW8+zejg==, figureFileBig=GLulxMKcP1vVNdzF3sxq+Q==, tableContent=null), ArticleFig(id=1316829970220044916, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1316714709223592235, language=EN, label=Figure 4, caption=Spearman correlation heatmap showing the associations between differential bacterial genera and differential bile acids. Red indicates positive correlations, whereas blue indicates negative correlations. 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