Article(id=1280817668580159683, tenantId=1146029695717560320, journalId=1192105938417971205, issueId=1280817479555462000, articleNumber=null, orderNo=null, doi=10.13343/j.cnki.wsxb.20260083, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1769529600000, receivedDateStr=2026-01-28, revisedDate=null, revisedDateStr=null, acceptedDate=1772121600000, acceptedDateStr=2026-02-27, onlineDate=1783300328631, onlineDateStr=2026-07-06, pubDate=1783094400000, pubDateStr=2026-07-04, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1783300328631, onlineIssueDateStr=2026-07-06, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1783300328631, creator=13701087609, updateTime=1783300328631, updator=13701087609, issue=Issue{id=1280817479555462000, tenantId=1146029695717560320, journalId=1192105938417971205, year='2026', volume='66', issue='7', pageStart='3121', pageEnd='3677', issueExtLink='null', onlineDate='null', pubDate='1783094400000', pubDateStr='2026-07-04', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1783300283564, creator='13701087609', updateTime=1783326087324, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1280925708813832745, tenantId=1146029695717560320, journalId=1192105938417971205, issueId=1280817479555462000, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1280925708813832746, tenantId=1146029695717560320, journalId=1192105938417971205, issueId=1280817479555462000, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=3425, endPage=3437, ext={EN=ArticleExt(id=1280817668953452740, articleId=1280817668580159683, tenantId=1146029695717560320, journalId=1192105938417971205, language=EN, title=Lactobacillus paragasseri CCFM1526 promotes the fermentative biotransformation of cyanocobalamin against chronic sleep deprivation-induced nerve injury via the corresponding mechanism, columnId=1192149543992045670, journalTitle=Acta Microbiologica Sinica, columnName=Research Article, runingTitle=null, highlight=null, articleAbstract=

Objective Cyanocobalamin (CN-CbI) requires to be converted into adenosylcobalamin (Ado-CbI) to exert neuroprotective effects, yet its conversion efficiency is impaired under conditions such as chronic sleep deprivation (CSD). This study aimed to obtain a bacterial strain with high efficiency in converting CN-CbI to Ado-CbI that could enhance neuroprotective effects. Methods Lactobacillus paragasseri CCFM1526, a strain capable of converting CN-CbI to Ado-CbI, was isolated via UPLC. A mouse model of CSD was established, and the cognitive functions of mice were evaluated by the novel object recognition and Morris water maze tests. The neuronal structure in the hippocampal dentate gyrus (DG) region was observed via histological staining. Tissue vitamin B₁₂ levels were measured, and the ERK/mTOR signaling pathway along with related neural protein expression was analyzed to assess the neuroprotective mechanism of the fermentation broth. Results Compared with CN-CbI supplementation alone, the fermentation broth of L. paragasseri CCFM1526 significantly improved the cognitive function and alleviated the structural damage in the hippocampal DG region of CSD mice. Intervention with the fermentation broth increased the total vitamin B₁₂ content in the liver, serum, and brain by 10.2%, 16.3%, and 29.0%, respectively (P<0.05). Meanwhile, it activated the ERK/mTOR signaling pathway, leading to increases of 21.5%, 52.4%, 17.3%, and 19.7% in the content of myelin basic protein, postsynaptic density protein 95, brain-derived neurotrophic factor, and nerve growth factor, respectively (P<0.05). Conclusion L. paragasseri CCFM1526 converts CN-CbI into Ado-CbI through fermentation, subsequently activating the ERK/mTOR signaling pathway and upregulating the expression of neurotrophic and myelin repair-related proteins, thereby alleviating CSD-induced nerve injury.

, authors=Xingru CHEN, Xin TANG, Bingyong MAO, Jianxin ZHAO, Qiuxiang ZHANG, Shumao CUI, authorsList=Xingru CHEN, Xin TANG, Bingyong MAO, Jianxin ZHAO, Qiuxiang ZHANG, Shumao CUI, authorCompany=null, correspAuthors=Shumao CUI, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1280817670517928145, articleId=1280817668580159683, tenantId=1146029695717560320, journalId=1192105938417971205, language=CN, title=副格氏乳杆菌CCFM1526促进氰钴胺发酵转化并缓解慢性睡眠剥夺诱导的神经损伤及机制, columnId=1192149544164012138, journalTitle=微生物学报, columnName=研究报告, runingTitle=null, highlight=null, articleAbstract=

目的 氰钴胺(cyanocobalamin, CN-CbI)需转化为腺苷钴胺(adenosylcobalamin, Ado-CbI)才能发挥神经保护作用，但在慢性睡眠剥夺(chronic sleep deprivation, CSD)等状态下其转化效率受限。本研究旨在筛选出能够高效转化CN-CbI为Ado-CbI，并协同发挥神经保护作用的菌株。 方法 通过超高效液相色谱(UPLC)筛选获得能将CN-CbI转化为Ado-CbI的菌株——副格氏乳杆菌CCFM1526；建立CSD小鼠模型，采用新物体识别实验和Morris水迷宫实验评价小鼠的认知功能，通过组织病理学观察海马DG区神经元结构；测定组织中维生素B₁₂ (vitamin B₁₂, VB₁₂)含量，并检测ERK/mTOR信号通路及相关神经蛋白的表达，以评价发酵液的神经保护机制。 结果 与单纯补充CN-CbI相比，CCFM1526发酵液显著提升了小鼠的认知能力，减轻了海马DG区神经元结构损伤。发酵液干预使小鼠肝脏、血清和脑中的总维生素B₁₂含量分别提升10.2%、16.3%和29.0% (P<0.05)，并激活了ERK/mTOR信号通路，使髓鞘碱性蛋白、突触后致密蛋白95、脑源性神经营养因子及神经生长因子的含量分别增加21.5%、52.4%、17.3%和19.7% (P<0.05)。 结论 副格氏乳杆菌CCFM1526通过发酵将CN-CbI转化为Ado-CbI，进而通过激活ERK/mTOR信号通路，上调神经营养与髓鞘修复相关蛋白的表达，从而缓解CSD诱导的神经损伤。

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Journal of Neuroinflammation, 2024, 21: 180., articleTitle=Chronic rapid eye movement sleep deprivation aggravates the pathogenesis of Alzheimer’s disease by decreasing brain O-GlcNAc cycling in mice, refAbstract=null), Reference(id=1280925246626698209, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1280817668580159683, doi=null, pmid=null, pmcid=null, year=2019, volume=176, issue=9, pageStart=1282, pageEnd=1297, url=null, language=null, rfNumber=[27], rfOrder=27, authorNames=Cao Y, Li QL, Liu LL, Wu H, Huang F, Wang CH, Lan YY, Zheng F, Xing FP, Zhou Q, Li Q, Shi HL, Zhang BB, Wang ZT, Wu XJ, journalName=British Journal of Pharmacology, refType=null, unstructuredReference=Cao Y, Li QL, Liu LL, Wu H, Huang F, Wang CH, Lan YY, Zheng F, Xing FP, Zhou Q, Li Q, Shi HL, Zhang BB, Wang ZT, Wu XJ. Modafinil protects hippocampal neurons by suppressing excessive autophagy and apoptosis in mice with sleep deprivation[J]. British Journal of Pharmacology, 2019, 176(9): 1282-1297., articleTitle=Modafinil protects hippocampal neurons by suppressing excessive autophagy and apoptosis in mice with sleep deprivation, refAbstract=null)], funds=[Fund(id=1280925242520474565, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1280817668580159683, awardId=null, language=EN, fundingSource=the Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, fundOrder=null, country=null)], companyList=[AuthorCompany(id=1280925237235651466, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1280817668580159683, xref=null, ext=[AuthorCompanyExt(id=1280925237244040075, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1280817668580159683, companyId=1280925237235651466, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, Jiangsu, China), AuthorCompanyExt(id=1280925237252428684, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1280817668580159683, companyId=1280925237235651466, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=江南大学，食品科学与资源挖掘全国重点实验室，江苏 无锡)])], figs=[ArticleFig(id=1280925241211851701, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1280817668580159683, language=EN, label=Figure 1, caption=UPLC analysis of CN-CbI fermentation conversion by Lactobacillus paragasseri CCFM1526. Slight retention time shift due to matrix complexity; The peak was confirmed as Ado-CbI by LC-MS/MS., figureFileSmall=BRDHylkLWEiTTW4J5EjcgQ==, figureFileBig=VmRsFpHgYtWzHo9ogppFpw==, tableContent=null), ArticleFig(id=1280925241274766262, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1280817668580159683, language=CN, label=图1, caption=副格氏乳杆菌CCFM1526发酵转化CN-CbI UPLC图谱, figureFileSmall=BRDHylkLWEiTTW4J5EjcgQ==, figureFileBig=VmRsFpHgYtWzHo9ogppFpw==, tableContent=null), ArticleFig(id=1280925241396401079, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1280817668580159683, language=EN, label=Figure 2, caption=Effects of different intragastric treatments on the behaviors of chronic sleep-deprived mice. A: NOR discrimination index; B: NOR recognition index; C: Number of platform crossings in the MWM; D: NOR trajectory map; E: MWM trajectory map. H-1526: Live 1526 group; H-1526+CN-CbI: Live 1526+CN-CbI group; F-1526: 1526 fermentation broth. * P<0.05, ** P<0.01, *** P<0.001, **** P<0.000 1 vs. the Model group; ^#P<0.05, ^##P<0.01, ^###P<0.001 vs. the CN-CbI group., figureFileSmall=71TgQK7NkvZvioGvxMEhaQ==, figureFileBig=tqKEFWUUnwwfOlw3nCjXOw==, tableContent=null), ArticleFig(id=1280925241455121336, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1280817668580159683, language=CN, label=图2, caption=不同灌胃物质对慢性睡眠剥夺小鼠行为学的影响, figureFileSmall=71TgQK7NkvZvioGvxMEhaQ==, figureFileBig=tqKEFWUUnwwfOlw3nCjXOw==, tableContent=null), ArticleFig(id=1280925241522230201, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1280817668580159683, language=EN, label=Figure 3, caption=HE staining of hippocampal DG region in mice. H-1526: Live 1526 group; H-1526+CN-CbI: Live 1526+CN-CbI group; F-1526: 1526 fermentation broth. Green arrows: Normal neurons; Yellow arrows: Damaged neurons. Scale bar=200 μm., figureFileSmall=1mztuNr9DzTD8ea+a/IsjA==, figureFileBig=e4sM27HsFo2yAAq5yAJCeA==, tableContent=null), ArticleFig(id=1280925241593533370, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1280817668580159683, language=CN, label=图3, caption=小鼠海马DG区HE染色结果, figureFileSmall=1mztuNr9DzTD8ea+a/IsjA==, figureFileBig=e4sM27HsFo2yAAq5yAJCeA==, tableContent=null), ArticleFig(id=1280925241677419451, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1280817668580159683, language=EN, label=Figure 4, caption=Effects of different intragastric treatments on VB₁₂ levels in mice. A:VB₁₂ content in liver; B: VB₁₂ content in serum; C: VB₁₂ content in brain. H-1526: Live 1526 group; H-1526+CN-CbI: Live 1526+CN-CbI group; F-1526: 1526 fermentation broth. * P<0.05, ** P<0.01, *** P<0.001, **** P<0.000 1 vs. the Model group; ^#P<0.05, ^##P<0.01, ^###P<0.001 vs. the CN-CbI group., figureFileSmall=tGbDFFojkyNYJxbvsjRjsQ==, figureFileBig=+94EF+eP9jQMifIgDAD8GQ==, tableContent=null), ArticleFig(id=1280925241748722620, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1280817668580159683, language=CN, label=图4, caption=不同灌胃物质对小鼠体内VB₁₂ 含量的影响, figureFileSmall=tGbDFFojkyNYJxbvsjRjsQ==, figureFileBig=+94EF+eP9jQMifIgDAD8GQ==, tableContent=null), ArticleFig(id=1280925241820025789, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1280817668580159683, language=EN, label=Figure 5, caption=Effects of different intragastric treatments on the central nervous system of mice. A: MBP; B: PSD-95; C: BDNF; D: NGF. H-1526: Live 1526 group; H-1526+CN-CbI: Live 1526+CN-CbI group; F-1526: 1526 fermentation broth. * P<0.05, ** P<0.01, *** P<0.001; **** P<0.000 1 vs. the Model group; ^#P<0.05, ^##P<0.01, ^###P<0.001 vs. the CN-CbI group., figureFileSmall=t+oOtO5jV1Hr/p7PtNI/AA==, figureFileBig=yb6xoRHQF+KW7v/YnWMHlw==, tableContent=null), ArticleFig(id=1280925241916494782, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1280817668580159683, language=CN, label=图5, caption=不同灌胃物质对小鼠中枢神经系统的影响, figureFileSmall=t+oOtO5jV1Hr/p7PtNI/AA==, figureFileBig=yb6xoRHQF+KW7v/YnWMHlw==, tableContent=null), ArticleFig(id=1280925241987797951, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1280817668580159683, language=EN, label=Figure 6, caption=Effects of different intragastric treatments on ERK and mTOR signaling pathways in mouse brain tissue. A: p-ERK; B: p-mTOR. H-1526: Live 1526 group; H-1526+CN-CbI: Live 1526+CN-CbI group; F-1526: 1526 fermentation broth. * P<0.05, ** P<0.01, *** P<0.001, **** P<0.000 1 vs. the Model group; ^#P<0.05, ^##P<0.01, ^###P<0.001 vs. the CN-CbI group., figureFileSmall=Ic6sW/P3mEcNg95+sgzPJQ==, figureFileBig=ibRaqxVVz8cBq+9D0rg0Jg==, tableContent=null), ArticleFig(id=1280925242059101120, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1280817668580159683, language=CN, label=图6, caption=不同灌胃物质对小鼠脑组织ERK和mTOR信号通路的影响, figureFileSmall=Ic6sW/P3mEcNg95+sgzPJQ==, figureFileBig=ibRaqxVVz8cBq+9D0rg0Jg==, tableContent=null), ArticleFig(id=1280925242159764417, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1280817668580159683, language=EN, label=Table 1, caption=

Animal experiment design

, figureFileSmall=null, figureFileBig=null, tableContent=

Group	Treatment
Control	Physiological saline
Model	CSD+Physiological saline
CN-CbI	CSD+70 μg/(kg·d) CN-CbI
Positive	CSD+70 μg/(kg·d) Me-CbI
H-1526	CSD+1×109 CFU live CCFM1526
H-1526+CN-CbI	CSD+70 μg/(kg·d) CN-CbI+1×109 CFU live CCFM1526
F-1526	CSD+Fermentation broth [70 μg/(kg·d) CN-CbI]

), ArticleFig(id=1280925242231067586, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1280817668580159683, language=CN, label=表1, caption=

动物实验方案

, figureFileSmall=null, figureFileBig=null, tableContent=

Group	Treatment
Control	Physiological saline
Model	CSD+Physiological saline
CN-CbI	CSD+70 μg/(kg·d) CN-CbI
Positive	CSD+70 μg/(kg·d) Me-CbI
H-1526	CSD+1×109 CFU live CCFM1526
H-1526+CN-CbI	CSD+70 μg/(kg·d) CN-CbI+1×109 CFU live CCFM1526
F-1526	CSD+Fermentation broth [70 μg/(kg·d) CN-CbI]

), ArticleFig(id=1280925242310759363, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1280817668580159683, language=EN, label=Table 2, caption=

Test results of CN-CbI fermentation by CCFM1526

, figureFileSmall=null, figureFileBig=null, tableContent=

Items	Parameter at 0 h	Parameter at 48 h
CN-CbI concentration/(μg/mL)	500.0	364.3
Ado-CbI concentration/(μg/mL)	0.0	52.1
CN-CbI conversion/%	-	27.1

), ArticleFig(id=1280925242386256836, tenantId=1146029695717560320, journalId=1192105938417971205, articleId=1280817668580159683, language=CN, label=表2, caption=

CCFM1526发酵CN-CbI测定结果

, figureFileSmall=null, figureFileBig=null, tableContent=

Items	Parameter at 0 h	Parameter at 48 h
CN-CbI concentration/(μg/mL)	500.0	364.3
Ado-CbI concentration/(μg/mL)	0.0	52.1
CN-CbI conversion/%	-	27.1

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