Article(id=1322190401197429213, tenantId=1146029695717560320, journalId=1319373162502258839, issueId=1322190316019499694, articleNumber=null, orderNo=null, doi=10.16016/j.2097-0927.202505045, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1747756800000, receivedDateStr=2025-05-21, revisedDate=1750348800000, revisedDateStr=2025-06-20, acceptedDate=null, acceptedDateStr=null, onlineDate=1793164356755, onlineDateStr=2026-10-28, pubDate=1756483200000, pubDateStr=2025-08-30, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793164356755, onlineIssueDateStr=2026-10-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793164356755, creator=13701087609, updateTime=1793164356755, updator=13701087609, issue=Issue{id=1322190316019499694, tenantId=1146029695717560320, journalId=1319373162502258839, year='2025', volume='47', issue='16', pageStart='1825', pageEnd='1980', issueExtLink='null', onlineDate='null', pubDate='1756483200000', pubDateStr='2025-08-30', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1793164336447, creator='13701087609', updateTime=1793164553187, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1322191225206198613, tenantId=1146029695717560320, journalId=1319373162502258839, issueId=1322190316019499694, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1322191225206198614, tenantId=1146029695717560320, journalId=1319373162502258839, issueId=1322190316019499694, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1825, endPage=1837, ext={EN=ArticleExt(id=1322190401428115934, articleId=1322190401197429213, tenantId=1146029695717560320, journalId=1319373162502258839, language=EN, title=Translational opportunities and barriers for blood-based biomarkers in Alzheimer’s disease: from discovery to implementation, columnId=1320434417353470541, journalTitle=Journal of Army Medical University, columnName=Expert Review, runingTitle=null, highlight=null, articleAbstract=

Alzheimer's disease (AD) is the most common type of dementia in the elderly population, imposed a substantial burden on families and society in China. Recent breakthroughs in anti-amyloid beta (Aβ) monoclonal antibody therapies have highlighted the urgent need for early and accurate diagnosis of AD. The advancement of highly sensitive and automated detection platforms for fluid biomarkers has positioned blood biomarkers (BBs) testing as promising tools for early detection, accurate diagnosis, progression monitoring, and therapeutic evaluation in AD. However, their clinical application still faces challenges, including standardization of detection and sample preprocessing, quality control, and confounding factors. Ongoing development of detection technologies and integration of artificial intelligence-driven analytical tools offer promising solutions to these challenges. In the future, efforts should focus on clinical translation pathways, multimodal integration, personalized medicine, and fostering global and national collaborations to accelerate the clinical application of BBs for AD.

, authors=Yanjiang WANG, Shan HUANG, authorsList=Yanjiang WANG, Shan HUANG, authorCompany=null, correspAuthors=Yanjiang WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=© 2025 Journal of Army Medical University, copyrightOwner=Editorial Office of Journal of Army Medical University, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322190402023707103, articleId=1322190401197429213, tenantId=1146029695717560320, journalId=1319373162502258839, language=CN, title=阿尔茨海默病血液标志物的突破与挑战：从实验室到临床的转化之路, columnId=1320434417496076879, journalTitle=陆军军医大学学报, columnName=专家述评, runingTitle=null, highlight=null, articleAbstract=

阿尔茨海默病（Alzheimer’s disease，AD）作为老年人群中最常见的神经退行性疾病，其防治已成为全球公共卫生的重要议题。我国AD患病率持续攀升，构成了严峻的社会医疗挑战。随着靶向β淀粉样蛋白（Amyloid-β，Aβ）的单克隆抗体类药物在临床治疗中取得突破性进展，建立早期精准诊断体系的需求日益凸显。在此背景下，基于高灵敏度自动化检测平台的血液生物标志物技术展现出独特优势，为AD的早期筛查、精准分型、病程动态监测及治疗响应评估提供了全新解决方案。然而，该技术的临床转化仍面临诸多挑战，包括检测标准化、样本前处理规范、质量控制体系建立以及复杂系统因素的干扰等。当前，通过持续优化检测技术并结合人工智能辅助分析，有望突破这些技术瓶颈。展望未来，AD血液标志物研究应重点关注以下方向：建立规范的临床转化路径、开发多模态整合诊断模型、挖掘个性化医疗潜力，以及加强全球多中心协作网络建设，从而加速其从实验室到临床的转化进程。

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Alzheimers Dement，2024，20（8）：7698-7714., articleTitle=Plasma miRNAs across the Alzheimer’s disease continuum：Relationship to central biomarkers, refAbstract=null)], funds=null, companyList=[AuthorCompany(id=1322190404154413536, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322190401197429213, xref=1, ext=[AuthorCompanyExt(id=1322190404162802145, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322190401197429213, companyId=1322190404154413536, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹Department of Neurology，Chongqing Key Laboratory of Aging and Brain Diseases，Army Medical Center of PLA/Daping Hospital of Third Military Medical University，Chongqing，China), AuthorCompanyExt(id=1322190404175385058, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322190401197429213, companyId=1322190404154413536, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹陆军特色医学中心（第三军医大学大坪医院）神经内科，衰老与脑疾病重庆市重点实验室，重庆)])], figs=[ArticleFig(id=1322190405635002872, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322190401197429213, language=EN, label=Table 1, caption=

Comparison of core blood biomarkers in AD

, figureFileSmall=null, figureFileBig=null, tableContent=

标志物	优点	缺点
Aβ42/40	AD特异性标志物 疾病上游标志物，早期诊断潜能 比值形式减小个体差异	黏性大，易受样本处理流程影响 血液中变化幅度小 易受外周代谢干扰
pTau217	在AD与非AD人群变化幅度大 早期出现血液中可检测的改变	非AD特异性 温度敏感，检测变异较大 修饰态易受样本处理及检测流程影响
pTau181	在AD与非AD人群变化幅度较大 早期改变	同pTau217缺点 修饰位点AD特异性较pTau217低 变化幅度低于pTau217
pTau231	早期发生可检测的改变 （较其他pTau更早） 具有早期诊断潜能	同pTau217缺点 修饰位点AD特异性较pTau217低 变化幅度低于pTau217
pTau217/Aβ42	在AD与非AD人群变化幅度最大 比值具备单一标志物优点 同时较单一标志物更稳定	同单一标志物缺点 检测成本增高
pTau181/Aβ42	比值具备单一标志物优点 同时较单一标志物更稳定	同单一标志物缺点 检测成本增高

), ArticleFig(id=1322190405802775033, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322190401197429213, language=CN, label=表1, caption=

AD血液核心1标志物对比

, figureFileSmall=null, figureFileBig=null, tableContent=

标志物	优点	缺点
Aβ42/40	AD特异性标志物 疾病上游标志物，早期诊断潜能 比值形式减小个体差异	黏性大，易受样本处理流程影响 血液中变化幅度小 易受外周代谢干扰
pTau217	在AD与非AD人群变化幅度大 早期出现血液中可检测的改变	非AD特异性 温度敏感，检测变异较大 修饰态易受样本处理及检测流程影响
pTau181	在AD与非AD人群变化幅度较大 早期改变	同pTau217缺点 修饰位点AD特异性较pTau217低 变化幅度低于pTau217
pTau231	早期发生可检测的改变 （较其他pTau更早） 具有早期诊断潜能	同pTau217缺点 修饰位点AD特异性较pTau217低 变化幅度低于pTau217
pTau217/Aβ42	在AD与非AD人群变化幅度最大 比值具备单一标志物优点 同时较单一标志物更稳定	同单一标志物缺点 检测成本增高
pTau181/Aβ42	比值具备单一标志物优点 同时较单一标志物更稳定	同单一标志物缺点 检测成本增高

), ArticleFig(id=1322190405878272506, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322190401197429213, language=EN, label=Table 2, caption=

Clinical application scenarios and efficacy of core blood biomarkers in AD

, figureFileSmall=null, figureFileBig=null, tableContent=

血液标志物	脑内病理相关性	临床应用场景及效能
		疾病诊断	疾病分期	疗效监测
Aβ42/40	中	中	差	中
pTau217	高	高	中	较高
pTau181	较高	高	中	较高
pTau231	较高	中	中	中
pTau217/Aβ42	高	高	较高	较高
pTau181/Aβ42	较高	高	中	较高

), ArticleFig(id=1322190405966352891, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322190401197429213, language=CN, label=表2, caption=

AD血液核心1标志物临床应用场景及效能

, figureFileSmall=null, figureFileBig=null, tableContent=

血液标志物	脑内病理相关性	临床应用场景及效能
		疾病诊断	疾病分期	疗效监测
Aβ42/40	中	中	差	中
pTau217	高	高	中	较高
pTau181	较高	高	中	较高
pTau231	较高	中	中	中
pTau217/Aβ42	高	高	较高	较高
pTau181/Aβ42	较高	高	中	较高

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