Article(id=1322954194440814981, tenantId=1146029695717560320, journalId=1319373162502258839, issueId=1322954180431847810, articleNumber=null, orderNo=null, doi=10.16016/j.2097-0927.202507093, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1753632000000, receivedDateStr=2025-07-28, revisedDate=1763308800000, revisedDateStr=2025-11-17, acceptedDate=null, acceptedDateStr=null, onlineDate=1793346459255, onlineDateStr=2026-10-30, pubDate=1765728000000, pubDateStr=2025-12-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1793346459255, onlineIssueDateStr=2026-10-30, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1793346459255, creator=13701087609, updateTime=1793346459255, updator=13701087609, issue=Issue{id=1322954180431847810, tenantId=1146029695717560320, journalId=1319373162502258839, year='2025', volume='47', issue='23', pageStart='2881', pageEnd='3008', issueExtLink='null', onlineDate='null', pubDate='1765728000000', pubDateStr='2025-12-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1793346455915, creator='13701087609', updateTime=1793346455915, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=2903, endPage=2912, ext={EN=ArticleExt(id=1322954194822496646, articleId=1322954194440814981, tenantId=1146029695717560320, journalId=1319373162502258839, language=EN, title=Armored IL15 or IL15 receptor adaptors enhance proliferation and anti-tumor activity of CD19-targeted CAR-NK cells, columnId=1320434418116837551, journalTitle=Journal of Army Medical University, columnName=Basic Medicine, runingTitle=null, highlight=null, articleAbstract=
Objective To construct CD19-targeted chimeric antigen receptor natural killer (CAR-NK) cells armored with interleukin15 (IL15) or IL15 receptor-linker (RLI) and preliminarily validate their proliferative capacity and anti-tumor activity in vitro.
Methods Natural killer cells (NK92 and NK92MI) from patients with human malignant non-Hodgkin lymphoma were cultured, and CD19-targeted CAR-NK cells armored with IL15 or RLI were prepared using retroviral vector particles. IL15 secretion was measured by ELISA, and proliferative capacity was assessed via CFSE dilution assays. Human B-lymphocytic leukemia cells (Nalm6-GFP-Luc) and human colon cancer cells overexpressing CD19 (hCD19-SW620-GFP-Luc) were cultured, with surface CD19 expression confirmed (>99% positivity for both). Anti-tumor activity was evaluated by measuring cytotoxicity at effector-to-target (E:T) ratios using luciferase-based assays (4/12 h), detecting surface CD107a expression via flow cytometry, and quantifying cytokine release using CBA assays.
Results NK92/NK92MI-CD19 CAR cells armored with IL15 or RLI were successfully generated. IL15 secretion was significantly higher in armored groups versus non-armored controls (P<0.01). Without IL-2 stimulation, IL15/RLI enhanced CAR-NK proliferation (P<0.05). Both armored designs significantly increased tumor-killing efficiency (P<0.05) and CD107a degranulation. IL15/RLI-armored NK92-CD19 CAR cells exhibited elevated release of IL2, IL10, IL6, TNF-α, sFas, IFN-γ, and Granulysin (P<0.05), while armored NK92MI-CD19 CAR cells showed additional increases in Granzyme A, Granzyme B, and Perforin (P<0.05).
Conclusion IL15/RLI-armored NK92/NK92MI-CD19 CAR cells demonstrate potent anti-tumor activity, supporting their combined clinical therapeutic potential for tumors.
, authors=Mengyuan YU, Xiuying LIU, Xiaotian ZHANG, Jiaying WANG, Zhiming LING, Jianxun WANG, authorsList=Mengyuan YU, Xiuying LIU, Xiaotian ZHANG, Jiaying WANG, Zhiming LING, Jianxun WANG, authorCompany=null, correspAuthors=Jianxun WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=© 2025 Journal of Army Medical University, copyrightOwner=Editorial Office of Journal of Army Medical University, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1322954199583031700, articleId=1322954194440814981, tenantId=1146029695717560320, journalId=1319373162502258839, language=CN, title=装甲IL15或IL15受体连接体增强靶向CD19的CAR-NK细胞增殖与抗肿瘤活性, columnId=1322954194918965639, journalTitle=陆军军医大学学报, columnName=基础医学·论著, runingTitle=null, highlight=null, articleAbstract=
目的 构建靶向CD19的装甲白细胞介素15(interleukin 15,IL15)或IL15受体连接体(receptor-linker-IL15,RLI)嵌合抗原受体NK细胞(chimeric antigen receptor NK cell,CAR-NK),并进行CAR-NK细胞体外增殖与抗肿瘤活性的初步验证。
方法 培养人恶性非霍奇金淋巴瘤患者的自然杀伤细胞(NK92和NK92MI),并用逆转录病毒载体颗粒制备靶向CD19且装甲IL15或RLI的CAR-NK细胞。采用ELISA法检测CAR-NK细胞IL15分泌水平、CFSE法检测CAR-NK细胞的增殖能力。培养人B淋巴白血病细胞Nalm6-GFP-Luc和过表达人类CD19蛋白的人结肠癌细胞hCD19-SW620-GFP-Luc,并检测其表面CD19靶抗原的表达水平。在评估CAR-NK抗肿瘤活性时,使用荧光素酶发光法检测4或12 h时CAR-NK细胞在不同效应细胞与靶细胞数量比例时的杀伤效率,并利用流式细胞术检测CAR-NK细胞肿瘤杀伤时表面CD107a表达,同时使用CBA法检测其细胞因子释放水平。
结果 成功构建了装甲IL15或RLI的NK92/NK92MI-CD19 CAR细胞,且装甲IL15或RLI的细胞组IL15分泌水平显著高于没有装甲的细胞(P<0.01)。在无IL-2刺激的情况下,IL15或RLI能够增强CAR-NK增殖能力(P<0.05)。Nalm6-GFP-Luc和hCD19-SW620-GFP-Luc细胞表面CD19高表达,阳性率分别为100.0%和99.7%,可以作为CD19 CAR的靶细胞。IL15或RLI能够增强NK92/NK92MI细胞来源的CAR-NK细胞的杀伤能力(P<0.05),以及CD107a的表达水平。装甲IL15或RLI的NK92-CD19 CAR细胞有更高的IL2、IL10、IL6、TNF-α、sFasL、IFN-γ、Granulysin释放水平(P<0.05),而装甲IL15或RLI的NK92MI-CD19 CAR细胞有更高的IL2、IL10、IL6、TNF-α、sFas、IFN-γ、Granzyme A、Granzyme B、Perforin、Granulysin释放水平(P<0.05)。
结论 装甲IL15或RLI的NK92/NK92MI-CD19 CAR细胞具有良好的抗肿瘤活性,IL15细胞因子与CAR-NK联用具有强大的临床抗肿瘤治疗应用潜力。
, authors=于梦圆, 刘秀盈, 章笑甜, 王佳颖, 凌志明, 王建勋, authorsList=于梦圆, 刘秀盈, 章笑甜, 王佳颖, 凌志明, 王建勋, authorCompany=null, correspAuthors=王建勋, authorNote=
YU Mengyuan and LIU Xiuying contributed equally to the artricle.
, correspAuthorsNote=
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=MdbUbkyIXVzwHftg4XEYug==, magXml=iksyHGM5UXkRazeyuq+Tzg==, pdfUrl=null, pdf=C1AIVWTZM+1QxX6bw7oijw==, pdfFileSize=1519087, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=dKtilFlZ4oInZFwV+AUNzA==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=kZODUI/1ml9PnlwaYHFjAg==, mapNumber=null, fund=null)}, authors=[Author(id=1322954200266703257, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322954201910870427, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, authorId=1322954200266703257, language=EN, stringName=Mengyuan YU, firstName=Mengyuan, middleName=null, lastName=YU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=
1College of Life Sciences,Beijing University of Chinese Medicine,Beijing,China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322954202066059676, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, authorId=1322954200266703257, language=CN, stringName=于梦圆, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=
1北京中医药大学生命科学学院,北京, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322954199994073493, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, xref=1, ext=[AuthorCompanyExt(id=1322954200006656406, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, companyId=1322954199994073493, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1College of Life Sciences,Beijing University of Chinese Medicine,Beijing,China), AuthorCompanyExt(id=1322954200027627927, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, companyId=1322954199994073493, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1北京中医药大学生命科学学院,北京)])]), Author(id=1322954202175111582, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322954202292552096, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, authorId=1322954202175111582, language=EN, stringName=Xiuying LIU, firstName=Xiuying, middleName=null, lastName=LIU, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=
1College of Life Sciences,Beijing University of Chinese Medicine,Beijing,China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322954202372243873, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, authorId=1322954202175111582, language=CN, stringName=刘秀盈, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=
1北京中医药大学生命科学学院,北京, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322954199994073493, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, xref=1, ext=[AuthorCompanyExt(id=1322954200006656406, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, companyId=1322954199994073493, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1College of Life Sciences,Beijing University of Chinese Medicine,Beijing,China), AuthorCompanyExt(id=1322954200027627927, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, companyId=1322954199994073493, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1北京中医药大学生命科学学院,北京)])]), Author(id=1322954202472907171, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322954202594541989, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, authorId=1322954202472907171, language=EN, stringName=Xiaotian ZHANG, firstName=Xiaotian, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=
1College of Life Sciences,Beijing University of Chinese Medicine,Beijing,China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322954202686816678, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, authorId=1322954202472907171, language=CN, stringName=章笑甜, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=
1北京中医药大学生命科学学院,北京, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322954199994073493, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, xref=1, ext=[AuthorCompanyExt(id=1322954200006656406, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, companyId=1322954199994073493, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1College of Life Sciences,Beijing University of Chinese Medicine,Beijing,China), AuthorCompanyExt(id=1322954200027627927, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, companyId=1322954199994073493, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1北京中医药大学生命科学学院,北京)])]), Author(id=1322954202770702760, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322954202850394538, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, authorId=1322954202770702760, language=EN, stringName=Jiaying WANG, firstName=Jiaying, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=
1College of Life Sciences,Beijing University of Chinese Medicine,Beijing,China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322954202925892011, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, authorId=1322954202770702760, language=CN, stringName=王佳颖, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=
1北京中医药大学生命科学学院,北京, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322954199994073493, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, xref=1, ext=[AuthorCompanyExt(id=1322954200006656406, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, companyId=1322954199994073493, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1College of Life Sciences,Beijing University of Chinese Medicine,Beijing,China), AuthorCompanyExt(id=1322954200027627927, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, companyId=1322954199994073493, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1北京中医药大学生命科学学院,北京)])]), Author(id=1322954202993000877, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1322954203093664175, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, authorId=1322954202993000877, language=EN, stringName=Zhiming LING, firstName=Zhiming, middleName=null, lastName=LING, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=
1College of Life Sciences,Beijing University of Chinese Medicine,Beijing,China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322954203185938864, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, authorId=1322954202993000877, language=CN, stringName=凌志明, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=
1北京中医药大学生命科学学院,北京, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322954199994073493, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, xref=1, ext=[AuthorCompanyExt(id=1322954200006656406, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, companyId=1322954199994073493, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1College of Life Sciences,Beijing University of Chinese Medicine,Beijing,China), AuthorCompanyExt(id=1322954200027627927, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, companyId=1322954199994073493, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1北京中医药大学生命科学学院,北京)])]), Author(id=1322954203265630642, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=Jianxun.Wang@bucm.edu.cn, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1322954203357905332, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, authorId=1322954203265630642, language=EN, stringName=Jianxun WANG, firstName=Jianxun, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=
1College of Life Sciences,Beijing University of Chinese Medicine,Beijing,China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1322954203626340789, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, authorId=1322954203265630642, language=CN, stringName=王建勋, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=
1北京中医药大学生命科学学院,北京, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1322954199994073493, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, xref=1, ext=[AuthorCompanyExt(id=1322954200006656406, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, companyId=1322954199994073493, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1College of Life Sciences,Beijing University of Chinese Medicine,Beijing,China), AuthorCompanyExt(id=1322954200027627927, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, companyId=1322954199994073493, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1北京中医药大学生命科学学院,北京)])])], keywords=[Keyword(id=1322954203756364214, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, language=EN, orderNo=1, keyword=chimeric antigen receptor NK cells), Keyword(id=1322954204028993975, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, language=EN, orderNo=2, keyword=interleukin 15), Keyword(id=1322954204125462968, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, language=EN, orderNo=3, keyword=anti-tumor activity), Keyword(id=1322954204192571833, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, language=EN, orderNo=4, keyword=proliferation), Keyword(id=1322954204268069306, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, language=CN, orderNo=1, keyword=嵌合抗原受体NK细胞), Keyword(id=1322954204343566779, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, language=CN, orderNo=2, keyword=白细胞介素15), Keyword(id=1322954204502950332, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, language=CN, orderNo=3, keyword=抗肿瘤活性), Keyword(id=1322954204565864893, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, language=CN, orderNo=4, keyword=细胞增殖)], refs=[Reference(id=1322954207506072011, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, doi=10.1007/s11684-018-0653-9, pmid=null, pmcid=null, year=2018, volume=12, issue=4, pageStart=440, pageEnd=450, url=null, language=null, rfNumber=1, rfOrder=0, authorNames=FANG F, XIAO W H, TIAN Z G, journalName=Front Med, refType=null, unstructuredReference=
FANG F,
XIAO W H,
TIAN Z G. Challenges of NK cell-based immunotherapy in the new era[J].
Front Med,
2018,
12(4):440-450., articleTitle=Challenges of NK cell-based immunotherapy in the new era, refAbstract=null), Reference(id=1322954207585763788, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, doi=10.1126/science.1198687, pmid=null, pmcid=null, year=2011, volume=331, issue=6013, pageStart=44, pageEnd=49, url=null, language=null, rfNumber=2, rfOrder=1, authorNames=VIVIER E, RAULET D H, MORETTA A, journalName=Science, refType=null, unstructuredReference=
VIVIER E,
RAULET D H,
MORETTA A,
et al. Innate or adaptive immunity—the example of natural killer cells[J].
Science,
2011,
331(6013):44-49., articleTitle=Innate or adaptive immunity—the example of natural killer cells, refAbstract=null), Reference(id=1322954207673844173, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, doi=10.1084/jem.145.1.1, pmid=null, pmcid=null, year=1977, volume=145, issue=1, pageStart=1, pageEnd=9, url=null, language=null, rfNumber=3, rfOrder=2, authorNames=GLIMCHER L, SHEN F W, CANTOR H, journalName=J Exp Med, refType=null, unstructuredReference=
GLIMCHER L,
SHEN F W,
CANTOR H. Identification of a cell-surface antigen selectively expressed on the natural killer cell[J].
J Exp Med,
1977,
145(1):1-9., articleTitle=Identification of a cell-surface antigen selectively expressed on the natural killer cell, refAbstract=null), Reference(id=1322954207782896078, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, doi=10.1111/j.1600-065X.2008.00604.x, pmid=null, pmcid=null, year=2008, volume=222, issue=null, pageStart=357, pageEnd=368, url=null, language=null, rfNumber=4, rfOrder=3, authorNames=CHEEVER M A, journalName=Immunol Rev, refType=null, unstructuredReference=
CHEEVER M A. Twelve immunotherapy drugs that could cure cancers[J].
Immunol Rev,
2008,
222:357-368., articleTitle=Twelve immunotherapy drugs that could cure cancers, refAbstract=null), Reference(id=1322954207845810639, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, doi=10.1016/j.cytogfr.2006.05.001, pmid=null, pmcid=null, year=2006, volume=17, issue=4, pageStart=259, pageEnd=280, url=null, language=null, rfNumber=5, rfOrder=4, authorNames=BUDAGIAN V, BULANOVA E, PAUS R, journalName=Cytokine Growth Factor Rev, refType=null, unstructuredReference=
BUDAGIAN V,
BULANOVA E,
PAUS R,
et al. IL-15/IL-15 receptor biology:a guided tour through an expanding universe[J].
Cytokine Growth Factor Rev,
2006,
17(4):259-280., articleTitle=IL-15/IL-15 receptor biology:a guided tour through an expanding universe, refAbstract=null), Reference(id=1322954207925502416, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, doi=10.1136/jitc-2020-000632, pmid=null, pmcid=null, year=2020, volume=8, issue=1, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=6, rfOrder=5, authorNames=DESBOIS M, BÉAL C, CHARRIER M, journalName=J Immunother Cancer, refType=null, unstructuredReference=
DESBOIS M,
BÉAL C,
CHARRIER M,
et al. IL-15 superagonist RLI has potent immunostimulatory properties on NK cells:implications for antimetastatic treatment[J].
J Immunother Cancer,
2020,
8(1):e000632., articleTitle=IL-15 superagonist RLI has potent immunostimulatory properties on NK cells:implications for antimetastatic treatment, refAbstract=null), Reference(id=1322954207984222673, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, doi=10.3389/fimmu.2025.1578660, pmid=null, pmcid=null, year=2025, volume=16, issue=null, pageStart=1578660, pageEnd=null, url=null, language=null, rfNumber=7, rfOrder=6, authorNames=ZHAO L J, QIU C T, CHEN H Y, journalName=Front Immunol, refType=null, unstructuredReference=
ZHAO L J,
QIU C T,
CHEN H Y,
et al. Construction of stable packaging cell lines for large-scale industrial BaEV-enveloped retroviral vector production[J].
Front Immunol,
2025,
16:1578660., articleTitle=Construction of stable packaging cell lines for large-scale industrial BaEV-enveloped retroviral vector production, refAbstract=null), Reference(id=1322954208047137234, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, doi=10.13241/j.cnki.pmb.2024.04.003, pmid=null, pmcid=null, year=2024, volume=24, issue=4, pageStart=612, pageEnd=616, url=null, language=null, rfNumber=8, rfOrder=7, authorNames=冯义超, 刘秀盈, 刘静静, journalName=现代生物医学进展, refType=null, unstructuredReference=冯义超,刘秀盈,刘静静,
等. 基于逆转录病毒载体构建稳定表达人CD19和荧光蛋白的SW620细胞株[J].
现代生物医学进展,
2024,
24(4):612-616., articleTitle=基于逆转录病毒载体构建稳定表达人CD19和荧光蛋白的SW620细胞株, refAbstract=null), Reference(id=1322954208122634707, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, doi=10.13241/j.cnki.pmb.2024.04.003, pmid=null, pmcid=null, year=2024, volume=24, issue=4, pageStart=612, pageEnd=616, url=null, language=null, rfNumber=8, rfOrder=8, authorNames=FENG Y C, LIU X Y, LIU J J, journalName=Prog Mod Biomed, refType=null, unstructuredReference=
FENG Y C,
LIU X Y,
LIU J J,
et al. Construction of a SW620 cell line stably expressing human CD19 and fluorescent protein based on retroviral packaging technology[J].
Prog Mod Biomed,
2024,
24(4):612-616., articleTitle=Construction of a SW620 cell line stably expressing human CD19 and fluorescent protein based on retroviral packaging technology, refAbstract=null), Reference(id=1322954208193937876, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, doi=10.3389/fimmu.2018.01869, pmid=null, pmcid=null, year=2018, volume=9, issue=null, pageStart=1869, pageEnd=null, url=null, language=null, rfNumber=9, rfOrder=9, authorNames=ABEL A M, YANG C, THAKAR M S, journalName=Front Immunol, refType=null, unstructuredReference=
ABEL A M,
YANG C,
THAKAR M S,
et al. Natural killer cells:development,maturation,and clinical utilization[J].
Front Immunol,
2018,
9:1869., articleTitle=Natural killer cells:development,maturation,and clinical utilization, refAbstract=null), Reference(id=1322954208302989781, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, doi=null, pmid=null, pmcid=null, year=1998, volume=161, issue=12, pageStart=6977, pageEnd=6984, url=null, language=null, rfNumber=10, rfOrder=10, authorNames=CHAPOVAL A I, FULLER J A, KREMLEV S G, journalName=J Immunol, refType=null, unstructuredReference=
CHAPOVAL A I,
FULLER J A,
KREMLEV S G,
et al. Combination chemotherapy and IL-15 administration induce permanent tumor regression in a mouse lung tumor model:NK and T cell-mediated effects antagonized by B cells[J].
J Immunol,
1998,
161(12):6977-6984., articleTitle=Combination chemotherapy and IL-15 administration induce permanent tumor regression in a mouse lung tumor model:NK and T cell-mediated effects antagonized by B cells, refAbstract=null), Reference(id=1322954208386875862, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, doi=10.3389/fimmu.2015.00368, pmid=null, pmcid=null, year=2015, volume=6, issue=null, pageStart=368, pageEnd=null, url=null, language=null, rfNumber=11, rfOrder=11, authorNames=WANG W, ERBE A K, HANK J A, journalName=Front Immunol, refType=null, unstructuredReference=
WANG W,
ERBE A K,
HANK J A,
et al. NK cell-mediated antibody-dependent cellular cytotoxicity in cancer immunotherapy[J].
Front Immunol,
2015,
6:368., articleTitle=NK cell-mediated antibody-dependent cellular cytotoxicity in cancer immunotherapy, refAbstract=null), Reference(id=1322954208449790423, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, doi=null, pmid=null, pmcid=null, year=1994, volume=8, issue=4, pageStart=652, pageEnd=658, url=null, language=null, rfNumber=12, rfOrder=12, authorNames=GONG J H, MAKI G, KLINGEMANN H G, journalName=Leukemia, refType=null, unstructuredReference=
GONG J H,
MAKI G,
KLINGEMANN H G. Characterization of a human cell line (NK-92) with phenotypical and functional characteristics of activated natural killer cells[J].
Leukemia,
1994,
8(4):652-658., articleTitle=Characterization of a human cell line (NK-92) with phenotypical and functional characteristics of activated natural killer cells, refAbstract=null), Reference(id=1322954208512704984, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, doi=10.3969/j.issn.1672-4992.2022.05.006, pmid=null, pmcid=null, year=2022, volume=30, issue=5, pageStart=785, pageEnd=791, url=null, language=null, rfNumber=13, rfOrder=13, authorNames=余卓营, 李晓瑞, 尚凤琴, journalName=现代肿瘤医学, refType=null, unstructuredReference=余卓营,李晓瑞,尚凤琴,
等. 靶向CD19和BCMA的CAR-NK92MI细胞的构建及抗肿瘤活性研究[J].
现代肿瘤医学,
2022,
30(5):785-791., articleTitle=靶向CD19和BCMA的CAR-NK92MI细胞的构建及抗肿瘤活性研究, refAbstract=null), Reference(id=1322954208609173977, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, doi=10.3969/j.issn.1672-4992.2022.05.006, pmid=null, pmcid=null, year=2022, volume=30, issue=5, pageStart=785, pageEnd=791, url=null, language=null, rfNumber=13, rfOrder=14, authorNames=YU Z Y, LI X R, SHANG F Q, journalName=J Mod Oncol, refType=null, unstructuredReference=
YU Z Y,
LI X R,
SHANG F Q,
et al. Construction and antitumor activity of CAR-NK92MI cells targeting CD19 and BCMA[J].
J Mod Oncol,
2022,
30(5):785-791., articleTitle=Construction and antitumor activity of CAR-NK92MI cells targeting CD19 and BCMA, refAbstract=null), Reference(id=1322954208688865754, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, doi=10.1089/hum.2018.247, pmid=null, pmcid=null, year=2019, volume=30, issue=4, pageStart=381, pageEnd=401, url=null, language=null, rfNumber=14, rfOrder=15, authorNames=KLOESS S, OBERSCHMIDT O, DAHLKE J, journalName=Hum Gene Ther, refType=null, unstructuredReference=
KLOESS S,
OBERSCHMIDT O,
DAHLKE J,
et al. Preclinical assessment of suitable natural killer cell sources for chimeric antigen receptor natural killer-based “off-the-shelf ” acute myeloid leukemia immunotherapies[J].
Hum Gene Ther,
2019,
30(4):381-401., articleTitle=Preclinical assessment of suitable natural killer cell sources for chimeric antigen receptor natural killer-based “off-the-shelf ” acute myeloid leukemia immunotherapies, refAbstract=null), Reference(id=1322954208789529051, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, doi=10.1016/j.imlet.2017.09.012, pmid=null, pmcid=null, year=2017, volume=192, issue=null, pageStart=35, pageEnd=41, url=null, language=null, rfNumber=15, rfOrder=16, authorNames=PASLEY S, ZYLBERBERG C, MATOSEVIC S, journalName=Immunol Lett, refType=null, unstructuredReference=
PASLEY S,
ZYLBERBERG C,
MATOSEVIC S. Natural killer-92 cells maintain cytotoxic activity after long-term cryopreservation in novel DMSO-free media[J].
Immunol Lett,
2017,
192:35-41., articleTitle=Natural killer-92 cells maintain cytotoxic activity after long-term cryopreservation in novel DMSO-free media, refAbstract=null), Reference(id=1322954208885998044, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, doi=10.1080/14653240310001523, pmid=null, pmcid=null, year=2003, volume=5, issue=3, pageStart=259, pageEnd=272, url=null, language=null, rfNumber=16, rfOrder=17, authorNames=TAM Y K, MARTINSON J A, DOLIGOSA K, journalName=Cytotherapy, refType=null, unstructuredReference=
TAM Y K,
MARTINSON J A,
DOLIGOSA K,
et al.
Ex vivo expansion of the highly cytotoxic human natural killer-92 cell-line under current good manufacturing practice conditions for clinical adoptive cellular immunotherapy[J].
Cytotherapy,
2003,
5(3):259-272., articleTitle=
Ex vivo expansion of the highly cytotoxic human natural killer-92 cell-line under current good manufacturing practice conditions for clinical adoptive cellular immunotherapy, refAbstract=null), Reference(id=1322954208961495517, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, doi=10.1080/01616412.1986.11739735, pmid=null, pmcid=null, year=1986, volume=8, issue=2, pageStart=81, pageEnd=87, url=null, language=null, rfNumber=17, rfOrder=18, authorNames=JACOBS S K, WILSON D J, MELIN G, journalName=Neurol Res, refType=null, unstructuredReference=
JACOBS S K,
WILSON D J,
MELIN G,
et al. Interleukin-2 and lymphokine activated killer (LAK) cells in the treatment of malignant glioma:clinical and experimental studies[J].
Neurol Res,
1986,
8(2):81-87., articleTitle=Interleukin-2 and lymphokine activated killer (LAK) cells in the treatment of malignant glioma:clinical and experimental studies, refAbstract=null), Reference(id=1322954209066353118, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, doi=10.1126/science.288.5466.675, pmid=null, pmcid=null, year=2000, volume=288, issue=5466, pageStart=675, pageEnd=678, url=null, language=null, rfNumber=18, rfOrder=19, authorNames=KU C C, MURAKAMI M, SAKAMOTO A, journalName=Science, refType=null, unstructuredReference=
KU C C,
MURAKAMI M,
SAKAMOTO A,
et al. Control of homeostasis of CD8
+ memory T cells by opposing cytokines[J].
Science,
2000,
288(5466):675-678., articleTitle=Control of homeostasis of CD8
+ memory T cells by opposing cytokines, refAbstract=null), Reference(id=1322954209137656287, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, doi=10.3389/fimmu.2023.1141208, pmid=null, pmcid=null, year=2023, volume=14, issue=null, pageStart=1141208, pageEnd=null, url=null, language=null, rfNumber=19, rfOrder=20, authorNames=SINDACO P, PANDEY H, ISABELLE C, journalName=Front Immunol, refType=null, unstructuredReference=
SINDACO P,
PANDEY H,
ISABELLE C,
et al. The role of interleukin-15 in the development and treatment of hematological malignancies[J].
Front Immunol,
2023,
14:1141208., articleTitle=The role of interleukin-15 in the development and treatment of hematological malignancies, refAbstract=null), Reference(id=1322954209204765152, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, doi=10.3389/fimmu.2021.610789, pmid=null, pmcid=null, year=2021, volume=12, issue=null, pageStart=610789, pageEnd=null, url=null, language=null, rfNumber=20, rfOrder=21, authorNames=WANG X, ZHAO X Y, journalName=Front Immunol, refType=null, unstructuredReference=
WANG X,
ZHAO X Y. Transcription factors associated with IL-15 cytokine signaling during NK cell development[J].
Front Immunol,
2021,
12:610789., articleTitle=Transcription factors associated with IL-15 cytokine signaling during NK cell development, refAbstract=null), Reference(id=1322954210869903841, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, doi=10.1155/2017/1975902, pmid=null, pmcid=null, year=2017, volume=2017, issue=null, pageStart=1975902, pageEnd=null, url=null, language=null, rfNumber=21, rfOrder=22, authorNames=VAN DEN BERGH J J, SMITS E M, VERSTEVEN M, journalName=J Immunol Res, refType=null, unstructuredReference=
VAN DEN BERGH J J,
SMITS E M,
VERSTEVEN M,
et al. Characterization of interleukin-15-transpresenting dendritic cells for clinical use[J].
J Immunol Res,
2017,
2017:1975902., articleTitle=Characterization of interleukin-15-transpresenting dendritic cells for clinical use, refAbstract=null), Reference(id=1322954211016704482, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, doi=10.1016/0022-2836(91)90666-t, pmid=null, pmcid=null, year=1991, volume=219, issue=4, pageStart=717, pageEnd=725, url=null, language=null, rfNumber=22, rfOrder=23, authorNames=NORMAN D G, BARLOW P N, BARON M, journalName=J Mol Biol, refType=null, unstructuredReference=
NORMAN D G,
BARLOW P N,
BARON M,
et al. Three-dimensional structure of a complement control protein module in solution[J].
J Mol Biol,
1991,
219(4):717-725., articleTitle=Three-dimensional structure of a complement control protein module in solution, refAbstract=null), Reference(id=1322954211092201955, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, doi=10.1074/jbc.274.38.26978, pmid=null, pmcid=null, year=1999, volume=274, issue=38, pageStart=26978, pageEnd=26984, url=null, language=null, rfNumber=23, rfOrder=24, authorNames=DUBOIS S, MAGRANGEAS F, LEHOURS P, journalName=J Biol Chem, refType=null, unstructuredReference=
DUBOIS S,
MAGRANGEAS F,
LEHOURS P,
et al. Natural splicing of exon 2 of human interleukin-15 receptor α-chain mRNA results in a shortened form with a distinct pattern of expression[J].
J Biol Chem,
1999,
274(38):26978-26984., articleTitle=Natural splicing of exon 2 of human interleukin-15 receptor α-chain mRNA results in a shortened form with a distinct pattern of expression, refAbstract=null), Reference(id=1322954211171893732, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, doi=10.1182/blood-2007-03-080697, pmid=null, pmcid=null, year=2008, volume=112, issue=12, pageStart=4411, pageEnd=4419, url=null, language=null, rfNumber=24, rfOrder=25, authorNames=WU Z, XUE H H, BERNARD J, journalName=Blood, refType=null, unstructuredReference=
WU Z,
XUE H H,
BERNARD J,
et al. The IL-15 receptor α chain cytoplasmic domain is critical for normal IL-15 Ralpha function but is not required for trans-presentation[J].
Blood,
2008,
112(12):4411-4419., articleTitle=The IL-15 receptor α chain cytoplasmic domain is critical for normal IL-15 Ralpha function but is not required for trans-presentation, refAbstract=null)], funds=null, companyList=[AuthorCompany(id=1322954199994073493, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, xref=1, ext=[AuthorCompanyExt(id=1322954200006656406, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, companyId=1322954199994073493, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1College of Life Sciences,Beijing University of Chinese Medicine,Beijing,China), AuthorCompanyExt(id=1322954200027627927, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, companyId=1322954199994073493, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
1北京中医药大学生命科学学院,北京)])], figs=[ArticleFig(id=1322954204704276926, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, language=EN, label=Figure 1, caption=
Schematic diagram of the CD19 CAR structure of the armor IL15 or RLI, figureFileSmall=GAK2NuRpRrn7DcFzclH76w==, figureFileBig=dKtilFlZ4oInZFwV+AUNzA==, tableContent=null), ArticleFig(id=1322954206348444096, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, language=CN, label=图1, caption=
装甲IL15或RLI的CD19 CAR结构示意图, figureFileSmall=GAK2NuRpRrn7DcFzclH76w==, figureFileBig=dKtilFlZ4oInZFwV+AUNzA==, tableContent=null), ArticleFig(id=1322954206663016897, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, language=EN, label=Figure 2, caption=
Preparation of CD19 CAR-NK cells with armor IL15 or RLI, figureFileSmall=RwCQL4HcfNIEdZDjz2jHEA==, figureFileBig=qfByRmLVdkx/nrNllFr4yQ==, tableContent=null), ArticleFig(id=1322954206738514370, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, language=CN, label=图2, caption=
装甲IL15或RLI的CD19 CAR-NK细胞制备A:The transfection efficiency of BaEV-PackRV cells ;B:The transduction efficiency of CAR-NK92 cells;C:The secretion level of IL15 in CAR-NK92 cells;D:The transduction efficiency of CAR-NK92MI cells;E:The secretion level of IL15 in CAR-NK92MI cells
, figureFileSmall=RwCQL4HcfNIEdZDjz2jHEA==, figureFileBig=qfByRmLVdkx/nrNllFr4yQ==, tableContent=null), ArticleFig(id=1322954206834983363, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, language=EN, label=Figure 3, caption=
The proliferation ability of CD19 CAR-NK cells with armor IL15 or RLI, figureFileSmall=2smyMm+6TtROw9WqArsDdQ==, figureFileBig=oqQoBepcJG9wJUXnIQMQQw==, tableContent=null), ArticleFig(id=1322954206927258052, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, language=CN, label=图3, caption=
装甲IL15或RLI的CD19 CAR-NK细胞的增殖能力A:The proliferation and viability curves of CAR-NK92 cells ;B:The proliferation ability of CAR-NK92 cells ;C:The proliferation and viability curves of CAR-NK92MI cells ;D:The proliferation ability of CAR-NK92MI cells
, figureFileSmall=2smyMm+6TtROw9WqArsDdQ==, figureFileBig=oqQoBepcJG9wJUXnIQMQQw==, tableContent=null), ArticleFig(id=1322954207023727045, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, language=EN, label=Figure 4, caption=
Expression level of CD19 on the surface of tumor cells, figureFileSmall=KebE83tUPo4ZVvX8YHoISg==, figureFileBig=Mj4LeTel2MWMPAmKG8o0LA==, tableContent=null), ArticleFig(id=1322954207095030214, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, language=CN, label=图4, caption=
肿瘤细胞表面CD19表达水平, figureFileSmall=KebE83tUPo4ZVvX8YHoISg==, figureFileBig=Mj4LeTel2MWMPAmKG8o0LA==, tableContent=null), ArticleFig(id=1322954207174721991, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, language=EN, label=Figure 5, caption=
The anti-tumor activity of CD19 CAR-NK92 cells armored with IL15 or RLI, figureFileSmall=1e1rKryvyzad4JGSx+UL2w==, figureFileBig=LI1pYZjPc5BZVOdw8yIVNw==, tableContent=null), ArticleFig(id=1322954207250219464, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, language=CN, label=图5, caption=
装甲IL15或RLI的CD19 CAR-NK92细胞的抗肿瘤活性A:The killing efficiency of CAR-NK92 on target cells at different effector-to-target ratios and different time periods;B:The expression level of CD107a on the surface of CAR-NK92 cells;C:The secretion level of CAR-NK92 cytokin-related cytokines
, figureFileSmall=1e1rKryvyzad4JGSx+UL2w==, figureFileBig=LI1pYZjPc5BZVOdw8yIVNw==, tableContent=null), ArticleFig(id=1322954207317328329, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, language=EN, label=Figure 6, caption=
The anti-tumor activity of CD19 CAR-NK92MI cells with armor IL15 or RLI, figureFileSmall=my6b1G+TehJsyhP1omwi4g==, figureFileBig=kHEr2Zr6SvIgUPiIDTsWQQ==, tableContent=null), ArticleFig(id=1322954207388631498, tenantId=1146029695717560320, journalId=1319373162502258839, articleId=1322954194440814981, language=CN, label=图6, caption=
装甲IL15或RLI的CD19 CAR-NK92MI细胞的抗肿瘤活性A:The killing efficiency of CAR-NK92MI on target cells at different effector-to-target ratios;B:The expression level of CD107a on the surface of CAR-NK92MI cells;C:The secretion level of CAR-NK92MI cytokin-related cytokines
, figureFileSmall=my6b1G+TehJsyhP1omwi4g==, figureFileBig=kHEr2Zr6SvIgUPiIDTsWQQ==, tableContent=null)], attaches=null, journal=Journal(id=1319372634082869396, delFlag=0, nameCn=陆军军医大学学报, nameEn=Journal of Army Medical University, nameHistory1=null, nameHistory2=null, issn=2097-0927, eissn=null, cn=50-1223/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=zdiTazv9TbsMJqLaCJ/k7A==, journalPrice=null, startedYear=null, abbrevIsoEn=Journal of Army Medical University, journalRemark=null, publicationField=null, createdTime=1792492548725, updatedTime=1792745216517, createdBy=18614031015, updatedBy=13701087609, firstLetterCn=L, firstLetterEn=L, subjectCode=Medical and Pharmaceutical Sciences, subjectName=null, subjectCodeEn=Medical and Pharmaceutical Sciences, subjectNameEn=null, picCn=zdiTazv9TbsMJqLaCJ/k7A==, picEn=931BgeD2k9AIsc7QjHoQKg==, jcr=null, cjcr=null, exts=[JournalExt(id=1320432400862135101, language=CN, name=陆军军医大学学报, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1792745216813, updatedTime=1792745216813, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=https://ljjydx.portal.founderss.cn, submissionEditorUrl=https://journal.ids.fzyun.cn, submissionReviewUrl=https://ljjydx.portal.founderss.cn, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1320432400933438270, language=EN, name=Journal of Army Medical University, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1792745216830, updatedTime=1792745216830, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=https://ljjydx.portal.founderss.cn, submissionEditorUrl=https://journal.ids.fzyun.cn, submissionReviewUrl=https://ljjydx.portal.founderss.cn, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1319373162502258839, websiteList=[Website(id=1319376331821925278, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1319373162502258839, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/ljjydxxb/CN, language=CN, createTime=1792493430333, createBy=18614031015, updateTime=1792493552921, updateBy=18614031015, name=陆军军医大学学报-中文, tplId=1146099689490845704, title=陆军军医大学学报, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1319376971570729589, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1319376331821925278, code=articleTextType, value=kx, createTime=1792493582861, updateTime=1792493582861, creator=18614031015, updator=18614031015), WebsiteProps(id=1319376971549758066, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1319376331821925278, code=banner, value=null, createTime=1792493582856, updateTime=1792493582856, creator=18614031015, updator=18614031015), WebsiteProps(id=1319376971591701112, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1319376331821925278, code=grayFlag, value=0, createTime=1792493582866, updateTime=1792493582866, creator=18614031015, updator=18614031015), WebsiteProps(id=1319376971541369457, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1319376331821925278, code=logo, value=https://castjournals.cast.org.cn/joweb/ljjydxxb/CN/file/pic?fileId=Mmvh7crXM7dcUwf9n9+ehg==, createTime=1792493582854, updateTime=1792493582854, creator=18614031015, updator=18614031015), WebsiteProps(id=1319376971608478330, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1319376331821925278, code=minRunFlag, value=0, createTime=1792493582870, updateTime=1792493582870, creator=18614031015, updator=18614031015), WebsiteProps(id=1319376971562340980, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1319376331821925278, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/ljjydxxb/CN/file/pic, createTime=1792493582859, updateTime=1792493582859, creator=18614031015, updator=18614031015), WebsiteProps(id=1319376971600089721, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1319376331821925278, code=silenceFlag, value=0, createTime=1792493582868, updateTime=1792493582868, creator=18614031015, updator=18614031015), WebsiteProps(id=1319376971558146675, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1319376331821925278, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1792493582858, updateTime=1792493582858, creator=18614031015, updator=18614031015), WebsiteProps(id=1319376971574923894, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1319376331821925278, code=themeColor, value=null, createTime=1792493582862, updateTime=1792493582862, creator=18614031015, updator=18614031015), WebsiteProps(id=1319376971583312503, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1319376331821925278, code=themeStyle, value=null, createTime=1792493582864, updateTime=1792493582864, creator=18614031015, updator=18614031015)]), Website(id=1319376331905811365, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1319373162502258839, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/ljjydxxb/EN, language=EN, createTime=1792493430353, createBy=18614031015, updateTime=1792493548158, updateBy=18614031015, name=陆军军医大学学报-英文, tplId=1146101810881728533, title=Journal of Army Medical University, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1319376935873008230, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1319376331905811365, code=articleTextType, value=kx, createTime=1792493574350, updateTime=1792493574350, creator=18614031015, updator=18614031015), WebsiteProps(id=1319376935843648099, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1319376331905811365, code=banner, value=null, createTime=1792493574343, updateTime=1792493574343, creator=18614031015, updator=18614031015), WebsiteProps(id=1319376935902368361, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1319376331905811365, code=grayFlag, value=0, createTime=1792493574357, updateTime=1792493574357, creator=18614031015, updator=18614031015), WebsiteProps(id=1319376935835259490, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1319376331905811365, code=logo, value=https://castjournals.cast.org.cn/joweb/ljjydxxb/EN/file/pic?fileId=Mmvh7crXM7dcUwf9n9+ehg==, createTime=1792493574341, updateTime=1792493574341, creator=18614031015, updator=18614031015), WebsiteProps(id=1319376935914951275, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1319376331905811365, code=minRunFlag, value=0, createTime=1792493574360, updateTime=1792493574360, creator=18614031015, updator=18614031015), WebsiteProps(id=1319376935864619621, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1319376331905811365, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/ljjydxxb/EN/file/pic, createTime=1792493574348, updateTime=1792493574348, creator=18614031015, updator=18614031015), WebsiteProps(id=1319376935906562666, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1319376331905811365, code=silenceFlag, value=0, createTime=1792493574358, updateTime=1792493574358, creator=18614031015, updator=18614031015), WebsiteProps(id=1319376935856231012, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1319376331905811365, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1792493574346, updateTime=1792493574346, creator=18614031015, updator=18614031015), WebsiteProps(id=1319376935881396839, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1319376331905811365, code=themeColor, value=null, createTime=1792493574352, updateTime=1792493574352, creator=18614031015, updator=18614031015), WebsiteProps(id=1319376935889785448, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1319376331905811365, code=themeStyle, value=null, createTime=1792493574354, updateTime=1792493574354, creator=18614031015, updator=18614031015)])], journalTitle=陆军军医大学学报, weixinUrl=null, journalUrl=https://aammt.tmmu.edu.cn/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Journal of Army Medical University, journalPhotoCn=zdiTazv9TbsMJqLaCJ/k7A==, journalPhotoEn=931BgeD2k9AIsc7QjHoQKg==, journalFirstLetter=L, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/ljjydxxb/CN/10.16016/j.2097-0927.202507093, detailUrlEn=https://castjournals.cast.org.cn/joweb/ljjydxxb/EN/10.16016/j.2097-0927.202507093, pdfUrlCn=https://castjournals.cast.org.cn/joweb/ljjydxxb/CN/PDF/10.16016/j.2097-0927.202507093, pdfUrlEn=https://castjournals.cast.org.cn/joweb/ljjydxxb/EN/PDF/10.16016/j.2097-0927.202507093, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=1, orderTime=1765728000000, fullTextJson=null, articleText=null, reference=null)