Article(id=1317885832590115322, tenantId=1146029695717560320, journalId=1316781422847033486, issueId=1317885672153797495, articleNumber=null, orderNo=null, doi=10.12449/JCH260837, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1767801600000, receivedDateStr=2026-01-08, revisedDate=null, revisedDateStr=null, acceptedDate=1770048000000, acceptedDateStr=2026-02-03, onlineDate=1792138067623, onlineDateStr=2026-10-16, pubDate=1787587200000, pubDateStr=2026-08-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792138067623, onlineIssueDateStr=2026-10-16, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792138067623, creator=13701087609, updateTime=1792138067623, updator=13701087609, issue=Issue{id=1317885672153797495, tenantId=1146029695717560320, journalId=1316781422847033486, year='2026', volume='42', issue='8', pageStart='1745', pageEnd='2000', issueExtLink='null', onlineDate='null', pubDate='1787587200000', pubDateStr='2026-08-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1792138029373, creator='13701087609', updateTime=1792138608261, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317888100290900262, tenantId=1146029695717560320, journalId=1316781422847033486, issueId=1317885672153797495, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317888100290900263, tenantId=1146029695717560320, journalId=1316781422847033486, issueId=1317885672153797495, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1990, endPage=1995, ext={EN=ArticleExt(id=1317885834041344507, articleId=1317885832590115322, tenantId=1146029695717560320, journalId=1316781422847033486, language=EN, title=Application value of human leukocyte antigen gene testing in screening for idiosyncratic drug-induced liver injury, columnId=1317885737828205560, journalTitle=Journal of Clinical Hepatology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

The pathogenesis of idiosyncratic drug-induced liver injury （IDILI） remains unclear due to the rarity and unpredictability of IDILI and a lack of effective in vitro and in vivo models. Recent studies have shown that human leukocyte antigen （HLA） gene polymorphisms are significantly associated with the susceptibility to IDILI induced by various drugs. This article systematically reviews the latest research advances in HLA gene testing for IDILI，with a focus on the association between specific HLA gene loci and genetic susceptibility to drug-induced liver injury caused by commonly used drugs，in order to highlight the significance of HLA gene testing in IDILI screening.

, authors=Xueyu Xiang, Tongdong Shi, authorsList=Xueyu Xiang, Tongdong Shi, authorCompany=null, correspAuthors=Tongdong Shi, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317885835870061054, articleId=1317885832590115322, tenantId=1146029695717560320, journalId=1316781422847033486, language=CN, title=人类白细胞抗原基因检测在特异质型药物性肝损伤筛查中的应用, columnId=1317885739623367674, journalTitle=临床肝胆病杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

特异质型药物性肝损伤（IDILI）因具有罕见性与难以预测性，且缺乏有效的体内外研究模型，其发病机制尚未完全阐明。近年来研究已证实，人类白细胞抗原（HLA）基因的多态性与多种药物所致IDILI的易感性显著相关。本文系统阐述了HLA基因检测在IDILI领域的最新研究进展，重点论述了特定HLA基因位点与常见导致药物性肝损伤药物的遗传易感性之间的关联，揭示了HLA基因检测在IDILI筛查中的重要意义。

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correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1317885836285297157, tenantId=1146029695717560320, journalId=1316781422847033486, articleId=1317885832590115322, authorId=1317885836201411075, language=EN, stringName=Xueyu Xiang, firstName=Xueyu, middleName=null, lastName=Xiang, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Infectious Diseases，The Second Affiliated Hospital of Chongqing Medical University； Key Laboratory of Molecular Biology for Infectious Diseases （Ministry of Education），Institute for Viral Hepatitis，Chongqing Medical University，Chongqing 401336，China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1317885836369183238, tenantId=1146029695717560320, journalId=1316781422847033486, articleId=1317885832590115322, authorId=1317885836201411075, language=CN, stringName=向雪雨, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, 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DOI: 10.1053/j.gastro.2022.11.036., articleTitle=Identification of reduced ERAP2 expression and a novel HLA allele as components of a risk score for susceptibility to liver injury due to amoxicillin-clavulanate, refAbstract=null)], funds=null, companyList=[AuthorCompany(id=1317885836113330687, tenantId=1146029695717560320, journalId=1316781422847033486, articleId=1317885832590115322, xref=null, ext=[AuthorCompanyExt(id=1317885836121719296, tenantId=1146029695717560320, journalId=1316781422847033486, articleId=1317885832590115322, companyId=1317885836113330687, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Infectious Diseases，The Second Affiliated Hospital of Chongqing Medical University； Key Laboratory of Molecular Biology for Infectious Diseases （Ministry of Education），Institute for Viral Hepatitis，Chongqing Medical University，Chongqing 401336，China), AuthorCompanyExt(id=1317885836134302209, tenantId=1146029695717560320, journalId=1316781422847033486, articleId=1317885832590115322, companyId=1317885836113330687, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=重庆医科大学附属第二医院感染病科，感染性疾病分子生物学教育部重点实验室，重庆医科大学病毒性肝炎研究所，重庆 401336)])], figs=[ArticleFig(id=1317885838357283346, tenantId=1146029695717560320, journalId=1316781422847033486, articleId=1317885832590115322, language=EN, label=Figure 1, caption=Mechanism of HLA gene-mediated IDILI, figureFileSmall=nJveTCZ7An5wm2DxTa9DOA==, figureFileBig=mhAWIzgNXkhJlwUUVfdRvQ==, tableContent=null), ArticleFig(id=1317885838416003603, tenantId=1146029695717560320, journalId=1316781422847033486, articleId=1317885832590115322, language=CN, label=图1, caption=HLA基因介导IDILI的机制

注：HDS，中草药及膳食补充剂；ATD，抗结核药物；TCR，T淋巴细胞受体；HLA，人类白细胞抗原；IDILI，特异质型药物性肝损伤；CD4，分化簇4；CD8，分化簇8。

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