Article(id=1317885825153618686, tenantId=1146029695717560320, journalId=1316781422847033486, issueId=1317885672153797495, articleNumber=null, orderNo=null, doi=10.12449/JCH260838, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1766678400000, receivedDateStr=2025-12-26, revisedDate=null, revisedDateStr=null, acceptedDate=1772640000000, acceptedDateStr=2026-03-05, onlineDate=1792138065850, onlineDateStr=2026-10-16, pubDate=1787587200000, pubDateStr=2026-08-25, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1792138065850, onlineIssueDateStr=2026-10-16, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1792138065850, creator=13701087609, updateTime=1792138065850, updator=13701087609, issue=Issue{id=1317885672153797495, tenantId=1146029695717560320, journalId=1316781422847033486, year='2026', volume='42', issue='8', pageStart='1745', pageEnd='2000', issueExtLink='null', onlineDate='null', pubDate='1787587200000', pubDateStr='2026-08-25', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1792138029373, creator='13701087609', updateTime=1792138608261, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1317888100290900262, tenantId=1146029695717560320, journalId=1316781422847033486, issueId=1317885672153797495, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1317888100290900263, tenantId=1146029695717560320, journalId=1316781422847033486, issueId=1317885672153797495, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1996, endPage=2000, ext={EN=ArticleExt(id=1317885825451414271, articleId=1317885825153618686, tenantId=1146029695717560320, journalId=1316781422847033486, language=EN, title=Liver-targeted therapies for improving mild cognitive impairment：Mechanism of action and treatment strategies, columnId=1317885737828205560, journalTitle=Journal of Clinical Hepatology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Mild cognitive impairment （MCI） is a critical precursor stage of Alzheimer’s disease，and the development of MCI is closely associated with liver function. As a core metabolic organ，the liver regulates cognitive function through the liver-brain axis. Epidemiological studies have shown the association between liver function parameters and MCI. The liver affects cognitive function by clearing peripheral β-amyloid （mainly via the PPARα-LRP-1 pathway），secreting hepatic factors such as FGF21 and sEH to modulate neuronal energy metabolism，and mediating oxidative stress and systemic inflammatory responses. Anti-inflammatory/antioxidant measures，dietary pattern adjustments，and aerobic exercise are currently effective strategies for regulating liver function and mitigating mild cognitive impairment. This article systematically reviews the role and mechanism of the liver-brain axis in MCI，in order to provide new perspectives for developing liver-targeted therapies for cognitive impairment.

, authors=Jinyu Li^{1, 2}, Heng Jiang³, Duiping Feng², Jisheng Nie³, authorsList=Jinyu Li, Heng Jiang, Duiping Feng, Jisheng Nie, authorCompany=null, correspAuthors=Jisheng Nie, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1317885827254964994, articleId=1317885825153618686, tenantId=1146029695717560320, journalId=1316781422847033486, language=CN, title=靶向肝脏改善轻度认知障碍的作用机制与治疗策略, columnId=1317885739623367674, journalTitle=临床肝胆病杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

轻度认知障碍（MCI）是阿尔茨海默病的重要前驱阶段，其发生与肝脏功能密切相关。肝脏作为代谢器官，通过肝-脑轴调控认知功能。流行病学提示肝功能指标与MCI存在关联。肝脏通过过氧化物酶体增殖物激活受体α-低密度脂蛋白受体相关蛋白质1通路清除外周β-淀粉样蛋白；分泌成纤维细胞生长因子21、可溶性环氧化物水解酶等肝因子调节神经元能量代谢；介导氧化应激与系统性炎症反应等途径影响认知功能。抗炎/抗氧化、饮食模式调整、有氧运动是调节肝脏降低MCI发生的有效措施。本综述系统阐述肝-脑轴在MCI中的作用和机制，为开发基于肝脏靶点的认知障碍治疗提供新视角。

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注：Aβ，β-淀粉样蛋白；PPARα，过氧化物酶体增殖物激活受体α；FGF21，成纤维细胞生长因子21；sEH，可溶性环氧化物水解酶；SELENOP，硒蛋白P；MANF，中脑星形胶质细胞源性神经营养因子；LRP-1，低密度脂蛋白受体相关蛋白质1；IL-6，白细胞介素6；TNF-α，肿瘤坏死因子α；CRP，C反应蛋白；ROS，活性氧；LPS，脂多糖。

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