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过去生命科学界普遍认为,只有细菌、古菌、藻类或部分植物才能直接合成并利用单质硫,哺乳动物体内的硫元素仅以含硫氨基酸或代谢化合物的形式存在。然而,日本东北大学与德国马克斯·普朗克高分子研究所等机构的联合研究打破了这一固有认知:人类和小鼠细胞不仅能自主合成由8个硫原子组成的环状单质硫(S8),还会将其储存在细胞器内,作为抵御脂质过氧化和铁死亡的重要防线。2026年9月24日,相关成果发表于《Science》。

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(图片来源:德国马克斯·普朗克高分子研究所官网)

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哺乳动物细胞自制单质硫抵御氧化损伤
科技导报 | 科技新闻 2026,44(18): 9-9
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科技导报 |科技新闻 2026 , 44 (18) : 9 -9
哺乳动物细胞自制单质硫抵御氧化损伤
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    出版时间: 2026-09-28
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    过去生命科学界普遍认为,只有细菌、古菌、藻类或部分植物才能直接合成并利用单质硫,哺乳动物体内的硫元素仅以含硫氨基酸或代谢化合物的形式存在。然而,日本东北大学与德国马克斯·普朗克高分子研究所等机构的联合研究打破了这一固有认知:人类和小鼠细胞不仅能自主合成由8个硫原子组成的环状单质硫(S8),还会将其储存在细胞器内,作为抵御脂质过氧化和铁死亡的重要防线。2026年9月24日,相关成果发表于《Science》。

    . 哺乳动物细胞自制单质硫抵御氧化损伤. 科技导报, 2026 , 44 (18) : 9 -9 .
    . Science & Technology Review, 2026 , 44 (18) : 9 -9 .
    过去生命科学界普遍认为,只有细菌、古菌、藻类或部分植物才能直接合成并利用单质硫,哺乳动物体内的硫元素仅以含硫氨基酸或代谢化合物的形式存在。然而,日本东北大学与德国马克斯·普朗克高分子研究所等机构的联合研究打破了这一固有认知:人类和小鼠细胞不仅能自主合成由8个硫原子组成的环状单质硫(S8),还会将其储存在细胞器内,作为抵御脂质过氧化和铁死亡的重要防线。2026年9月24日,相关成果发表于《Science》。
    S8极难溶于水,却很容易钻进富含脂质的细胞膜和脂滴中。由于缺乏高灵敏度的原位提取手段,常规生化检测很难捕捉到它的踪迹。为此,研究团队专门设计出一种像“捕兽夹”一样能捕获并稳定S8的分子胶囊,结合质谱定量分析与拉曼显微成像,首次在人和小鼠细胞的线粒体膜及脂滴中测出毫摩尔级别的S8储备。进一步溯源发现,原本为人熟知的一氧化氮合酶(NOS)和NADPH氧化酶,竟能在特定条件下催化含硫前体分子延长硫链,在动物细胞内合成出S8。
    细胞大费周章合成单质硫究竟有何用处?实验显示,一旦耗尽培养细胞内的S8,细胞膜脂质过氧化便会失控,进而诱发铁死亡;反之,外源补充经增溶处理的S8,则能显著保护脂肪细胞和血管内皮细胞免受氧化损伤。进一步的机制研究表明,S8会与细胞内的谷胱甘肽发生反应,源源不断地生成具有强抗氧化活性的过硫化物与多硫化物。在骨关节炎小鼠模型中,向关节腔局部注射增溶S8后,软骨组织的脂质过氧化损伤指标明显回落。
    纽约大学医学院Richard Possemato在同期《Science》发表评述指出,S8本身并非直接“冲锋陷阵”清除自由基的抗氧化剂,而是细胞设在脂滴和线粒体里的“硫元素战略仓库”,随时为过硫化物防御体系提供原料。这一发现也刷新了人们对脂滴的认识——它绝非单纯堆积脂肪的液滴,而是主动参与局部氧化还原调控的防御前哨。值得注意的是,该研究还观察到乳腺癌周围脂肪组织中的S8水平异常升高,暗示肿瘤细胞可能也在利用这套机制逃避铁死亡,为未来抗肿瘤与抗炎干预提供了全新靶点。
    (综合:《Science》、日本东北大学官网、马克斯·普朗克高分子研究网)

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    2种不同金属材料的力学参数
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    属数
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    种数
    Number of
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    占总种数比例
    Percentage of
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    属
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    鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
    小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
    多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
    红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
    小菇属 Mycena 11 5.26
    光柄菇属 Pluteus 5 2.39
    红菇属 Russula 17 8.13
    栓菌属 Trametes 5 2.39
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