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一轮抗生素治疗后,培养皿里常剩下极少数细菌。它们未必带有耐药突变,只是暂时把代谢和生长速率降低,等药物撤走后重新繁殖。这类“持留细胞”让慢性感染容易反复。过去的解释多把它们看成独自蛰伏的“幸存者”,贝勒医学院等机构的研究发现,“邻居”细胞还会把现成蛋白送过去。2026年6月26日,相关研究成果发表于《Science》

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(图片来源:贝勒医学院官网)

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    一轮抗生素治疗后,培养皿里常剩下极少数细菌。它们未必带有耐药突变,只是暂时把代谢和生长速率降低,等药物撤走后重新繁殖。这类“持留细胞”让慢性感染容易反复。过去的解释多把它们看成独自蛰伏的“幸存者”,贝勒医学院等机构的研究发现,“邻居”细胞还会把现成蛋白送过去。2026年6月26日,相关研究成果发表于《Science》

    . 细菌如何在抗生素处理后“死灰复燃”. 科技导报, 2026 , 44 (13) : 8 -8 .
    . Science & Technology Review, 2026 , 44 (13) : 8 -8 .
    一轮抗生素治疗后,培养皿里常剩下极少数细菌。它们未必带有耐药突变,只是暂时把代谢和生长速率降低,等药物撤走后重新繁殖。这类“持留细胞”让慢性感染容易反复。过去的解释多把它们看成独自蛰伏的“幸存者”,贝勒医学院等机构的研究发现,“邻居”细胞还会把现成蛋白送过去。2026年6月26日,相关研究成果发表于《Science》
    研究团队在大肠杆菌中建立了一把只对蛋白转移亮灯的开关:供体细胞制造Cre酶,受体细胞带着只有Cre进入后才会翻转的遗传标记。结果显示,正常培养时开关很少被触发;加入低剂量、非致死浓度的抗生素后,转移频率增加数千倍。
    这一设计排除了常见的基因水平转移。Cre必须以蛋白身份进入受体,才会在其DNA上留下永久痕迹。研究人员移走供体,只保留培养上清,受体仍能翻转开关,说明细胞不必直接接触。在生化分离和高分辨率成像后找到了运载工具:从细菌膜上鼓出并脱落的微小囊泡。
    膜囊泡像从细胞表面捏下的一只只密封袋,里面可装蛋白、脂质和其他分子。抗生素让同一群遗传背景相同的细菌分化成2种状态。供体启动膜应激反应,增加囊泡释放;受体降低自身蛋白合成和代谢,却更容易接收外来的蛋白。群体并非整齐地一起休眠,而是在压力下临时分工。
    单细胞转录组显示,受体富集持留相关的表达特征,其中Hi‐pA活性较高。HipA是一种毒素-抗毒素系统成员,可抑制翻译并促使细胞进入低活性状态。去掉Hi‐pA后,受体摄取囊泡和在抗生素中存活的能力都下降。先给细胞加入浓缩囊泡,再用致死剂量抗生素处理,幸存比例也会上升。
    蛋白互送并不限于同一株大肠杆菌。研究人员观察到不同菌株之间乃至不同物种之间的转移。
    后续较为现实的研究方向,是鉴定囊泡内最能提高存活的蛋白,并在动物感染模型中阻断囊泡形成或摄取,观察标准抗生素能否清除残余细菌。
    (综合:《Science》、EurekAlert、贝勒医学院官网)

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    2种不同金属材料的力学参数

    Family
    属数
    Number of
    genus
    种数
    Number of
    species
    占总种数比例
    Percentage of
    total species (%)

    Genus
    种数
    Number of
    species
    占总种数比例
    Percentage of total
    species (%)
    鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
    小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
    多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
    红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
    小菇属 Mycena 11 5.26
    光柄菇属 Pluteus 5 2.39
    红菇属 Russula 17 8.13
    栓菌属 Trametes 5 2.39
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