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通过快速冷冻蛋白质并以电子束轰击，冷冻电子显微镜（cryo-EM）彻底改变了结构生物学，揭示了数千种无法结晶且难以通过传统X射线分析解析的蛋白质结构。如今，一项激光驱动的技术升级有望进一步拓展该技术的应用范围，使其中最小、最难观测的靶点清晰可见。

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（图片来源：《Science》）

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（图片来源：bioRxiv）

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