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流感大流行通常可追溯至禽源性甲型流感病毒（influenza Avirus，IAV）跨物种传播至人类。然而，人体抵御IAV传播的天然屏障机制尚不明确。浙江大学医学院附属第二医院肿瘤研究所所长于晓方团队，系统揭示了人体先天免疫系统中一条关键防御通路，在限制禽源流感病毒跨物种传播中的重要作用，不仅推进了病毒感染与跨物种传播防控研究，也为肿瘤免疫和自身免疫疾病相关机制研究提供了全新工具。2026年2月26日，相关研究成果发表于《Science》。

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（图片来源：浙江大学官网）

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