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脂肪组织随年龄增长的异常扩张是中年代谢综合征的重要诱因，但其细胞机制长期不明。美国希望之城医学中心王琼团队联合加州大学洛杉矶分校杨霞团队于2025年4月25日在《Science》发表研究，首次发现中年特异性脂肪前体细胞（CP-A）及其调控通路，为“中年发福”提供全新解释。

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