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柑橘黄龙病被称为“柑橘界的癌症”,这种由亚洲韧皮杆菌引发的毁灭性病害,已肆虐全球近50个国家,导致柑橘产业年均损失超百亿美元。2025年4月11日,中国科学院微生物研究所叶健团队宣布破解柑橘抗黄龙病的分子机制,并筛选出可有效防控该病害的小肽药物。该成果作为封面文章发表在《Science》。

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(图片来源:科学网)

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    柑橘黄龙病被称为“柑橘界的癌症”,这种由亚洲韧皮杆菌引发的毁灭性病害,已肆虐全球近50个国家,导致柑橘产业年均损失超百亿美元。2025年4月11日,中国科学院微生物研究所叶健团队宣布破解柑橘抗黄龙病的分子机制,并筛选出可有效防控该病害的小肽药物。该成果作为封面文章发表在《Science》。

    . 柑橘“癌症”黄龙病被攻克. 科技导报, 2025 , 43 (8) : 2 -7 .
    . Science & Technology Review, 2025 , 43 (8) : 2 -7 .
    柑橘黄龙病被称为“柑橘界的癌症”,这种由亚洲韧皮杆菌引发的毁灭性病害,已肆虐全球近50个国家,导致柑橘产业年均损失超百亿美元。2025年4月11日,中国科学院微生物研究所叶健团队宣布破解柑橘抗黄龙病的分子机制,并筛选出可有效防控该病害的小肽药物。该成果作为封面文章发表在《Science》。
    黄龙病菌(CLas)感染柑橘后,会分泌一种SDE5效应蛋白,干扰植物防御指挥系统(茉莉酸信号通路)。SDE5会激活“破坏分子”PUB21酶,引导该酶攻击柑橘的防御系统MYC2蛋白。研究发现某些野生柑橘近缘植物(如花椒、咖喱)天生携带一种突变版PUB21酶(PUB21DN),不具备对MYC2的“攻击性”。
    基于上述机制,团队构建全球首个靶向稳定MYC2的药物筛选系统,利用深度学习从百万分子库中筛选出治疗小肽APP3- 14。该小肽通过阻断SDE5的“分子胶水”作用,从而抑制黄龙病菌定殖。在广西、江西等多地试验中,APP3-14单季防控效率达80%,显著减少“红鼻果”等病症。
    (综合央视新闻网、《Science》)

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    2种不同金属材料的力学参数

    Family
    属数
    Number of
    genus
    种数
    Number of
    species
    占总种数比例
    Percentage of
    total species (%)

    Genus
    种数
    Number of
    species
    占总种数比例
    Percentage of total
    species (%)
    鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
    小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
    多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
    红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
    小菇属 Mycena 11 5.26
    光柄菇属 Pluteus 5 2.39
    红菇属 Russula 17 8.13
    栓菌属 Trametes 5 2.39
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