Article(id=1242142904903349219, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1146500022830469878, articleNumber=null, orderNo=12, doi=null, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=null, receivedDateStr=null, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1744992000000, onlineDateStr=2025-04-19, pubDate=1743091200000, pubDateStr=2025-03-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1744992000000, onlineIssueDateStr=2025-04-19, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774079546427, creator=sys-migrate, updateTime=1774079546427, updator=sys-migrate, issue=Issue{id=1146500022830469878, tenantId=1146029695717560320, journalId=1146031591421210625, year='2025', volume='43', issue='6', pageStart='1', pageEnd='100', issueExtLink='null', onlineDate='null', pubDate='1743091200000', pubDateStr='2025-03-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1751276506383, creator='13701087609', updateTime=1774330962150, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1243197418926355120, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1146500022830469878, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1243197418926355121, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1146500022830469878, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=10, endPage=10, ext={EN=ArticleExt(id=1242142911366766908, articleId=1242142904903349219, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=null, columnId=null, journalTitle=Science & Technology Review, columnName=null, runingTitle=null, highlight=null, articleAbstract=null, authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=All rights reserved. Unauthorized reproduction is prohibited., copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242142907189240098, articleId=1242142904903349219, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=生物3D打印机助力活性器官制造, columnId=1157710593177338394, journalTitle=科技导报, columnName=科技新闻, runingTitle=null, highlight=null, articleAbstract=

浙江大学杨华勇和贺永团队研发了一种神奇的“生物打印机”——多材料投影式生物3D打印装备,不仅能像搭积木一样组合不同材料,还能打印出活性的器官结构。

, authors=null, authorsList=null, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=版权所有,未经授权,不得转载。, copyrightOwner=《科技导报》编辑部, extLink=null, articleAbsUrl=null, sourceXml=gnhzYgRH1Wg8Ye5amk0zwg==, magXml=gnhzYgRH1Wg8Ye5amk0zwg==, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=yR9nDeT1KIc3WwaT5nQExA==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=WQobs32u+G6fimxp2F947w==, mapNumber=null, fund=null)}, authors=null, keywords=null, refs=null, funds=null, companyList=null, figs=[ArticleFig(id=1242142912134324547, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242142904903349219, language=EN, label=null, caption=null, figureFileSmall=WVTTMtMtJsvoz8B0sOMMZw==, figureFileBig=yR9nDeT1KIc3WwaT5nQExA==, tableContent=null), ArticleFig(id=1242142912193044804, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242142904903349219, language=CN, label=图1, caption=开发的多材料投影式生物3D打印设备

(图片来源:《Research》)

, figureFileSmall=WVTTMtMtJsvoz8B0sOMMZw==, figureFileBig=yR9nDeT1KIc3WwaT5nQExA==, tableContent=null), ArticleFig(id=1242142912348234056, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242142904903349219, language=EN, label=null, caption=null, figureFileSmall=gg1qsbpJq7lhcBTeDwAEyA==, figureFileBig=BmB++08TzC7OeXdgtc0n1w==, tableContent=null), ArticleFig(id=1242142912423731529, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242142904903349219, language=CN, label=图2, caption=打印的多材料模型

(图片来源:《Research》)

, figureFileSmall=gg1qsbpJq7lhcBTeDwAEyA==, figureFileBig=BmB++08TzC7OeXdgtc0n1w==, tableContent=null)], attaches=null, journal=Journal(id=1125356956822126595, delFlag=0, nameCn=科技导报, nameEn=Science & Technology Review, nameHistory1=null, nameHistory2=null, issn=1000-7857, eissn=, cn=11-1421/N, coden=null, periodic=3, language=CN, oaType=0, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=wfghvu3bhh/dKxuZ+ucVHA==, journalPrice=null, startedYear=null, abbrevIsoEn=Sci Technol Rev, journalRemark=null, publicationField=null, createdTime=null, updatedTime=1784015846012, createdBy=null, updatedBy=13041195026, firstLetterCn=K, firstLetterEn=K, subjectCode=Natural Sciences, subjectName=自然科学, subjectCodeEn=Natural Sciences, subjectNameEn=null, picCn=wfghvu3bhh/dKxuZ+ucVHA==, picEn=yjSfclmpNm7ihn9NbTZ69g==, jcr=null, cjcr=null, exts=[JournalExt(id=1283818766098219763, language=CN, name=科技导报, nameHistory1=null, nameHistory2=null, managedBy=中国科学技术协会, sponsoredBy=中国科学技术协会, publishedBy=科技导报社, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=http://www.kjdb.org/CN/home, createdTime=1784015846037, updatedTime=1784015846037, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=http://www.kjdb.org/CN/column/column7.shtml, submissionAuthorUrl=https://kjdbauthor.cast.org.cn/webm, submissionEditorUrl=https://kjdbeditor.cast.org.cn/webm/, submissionReviewUrl=https://kjdbauthor.cast.org.cn/webm, submissionCeEditorUrl=https://kjdbeditor.cast.org.cn/webm/, submissionAeEditorUrl=https://kjdbeditor.cast.org.cn/webm/, option={"copyright":""}), JournalExt(id=1283818766144357108, language=EN, name=Science & Technology Review, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=http://www.kjdb.org/EN/home, createdTime=1784015846048, updatedTime=1784015846048, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=http://www.kjdb.org/EN/column/column7.shtml, submissionAuthorUrl=https://kjdbauthor.manuscriptcloud.com/login, submissionEditorUrl=https://kjdbeditor.manuscriptcloud.com/login, submissionReviewUrl=https://kjdbauthor.manuscriptcloud.com/login, submissionCeEditorUrl=https://kjdbeditor.manuscriptcloud.com/login, submissionAeEditorUrl=https://kjdbeditor.manuscriptcloud.com/login, option={"copyright":""})], databaseList=null, tenantJournalId=1146031591421210625, websiteList=[Website(id=1146104741081231361, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1146031591421210625, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/kjdb/CN, language=CN, createTime=1751182263881, createBy=18614031015, updateTime=1751778001962, updateBy=18614031015, name=科技导报, tplId=1146099689490845704, title=科技导报, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1148021146403992296, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=articleTextType, value=kx, createTime=1751639170504, updateTime=1751639170504, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146378826469, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=banner, value=null, createTime=1751639170498, updateTime=1751639170498, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146366243556, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=logo, value=https://castjournals.cast.org.cn/joweb/kjdb/CN/file/pic?fileId=9GHSf7eGlIPH0Tv/OOdstA==, createTime=1751639170495, updateTime=1751639170495, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146395603687, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/kjdb/CN/file/pic, createTime=1751639170502, updateTime=1751639170502, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146387215078, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1751639170500, updateTime=1751639170500, creator=18614031015, updator=18614031015)]), Website(id=1146105254833139715, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1146031591421210625, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/kjdb/EN, language=EN, createTime=1751182386363, createBy=18614031015, updateTime=1753500121937, updateBy=18614031015, name=科技导报, tplId=1146101810881728533, title=Science & Technology Review, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1155838567709528217, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=articleTextType, value=kx, createTime=1753502988984, updateTime=1753502988984, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567692750998, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=banner, value=null, createTime=1753502988980, updateTime=1753502988980, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567688556693, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=logo, value=https://castjournals.cast.org.cn/joweb/kjdb/EN/file/pic?fileId=9GHSf7eGlIPH0Tv/OOdstA==, createTime=1753502988979, updateTime=1753502988979, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567705333912, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/kjdb/EN/file/pic, createTime=1753502988983, updateTime=1753502988983, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567701139607, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1753502988982, updateTime=1753502988982, creator=18614031015, updator=18614031015)])], journalTitle=科技导报, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Science & Technology Review, journalPhotoCn=wfghvu3bhh/dKxuZ+ucVHA==, journalPhotoEn=yjSfclmpNm7ihn9NbTZ69g==, journalFirstLetter=K, journalRecommend=null, journalNew=null, journalCollection=1, jcrJf=null, cjcrJf=0.91, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/kjdb/CN/Y2025/V43/I6/10, detailUrlEn=https://castjournals.cast.org.cn/joweb/kjdb/EN/Y2025/V43/I6/10, pdfUrlCn=https://castjournals.cast.org.cn/joweb/kjdb/CN/PDF/Y2025/V43/I6/10, pdfUrlEn=https://castjournals.cast.org.cn/joweb/kjdb/EN/PDF/Y2025/V43/I6/10, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=1, orderTime=1743091200000, fullTextJson=null, articleText=null, reference=null)
收藏切换
生物3D打印机助力活性器官制造
收藏切换
PDF下载
科技导报 | 科技新闻 2025,43(6): 10-10
收起
收藏切换
科技导报 |科技新闻 2025 , 43 (6) : 10 -10
生物3D打印机助力活性器官制造
全屏
作者信息
  • Affiliations
    出版时间: 2025-03-28
    文章导航
    收藏切换

    浙江大学杨华勇和贺永团队研发了一种神奇的“生物打印机”——多材料投影式生物3D打印装备,不仅能像搭积木一样组合不同材料,还能打印出活性的器官结构。

    . 生物3D打印机助力活性器官制造. 科技导报, 2025 , 43 (6) : 10 -10 .
    . Science & Technology Review, 2025 , 43 (6) : 10 -10 .
    浙江大学杨华勇和贺永团队研发了一种神奇的“生物打印机”——多材料投影式生物3D打印装备,不仅能像搭积木一样组合不同材料,还能打印出活性的器官结构。
    与常规3D打印机不同,投影式生物打印机的“墨盒”里装的是含有活细胞的“生物墨水”。当打印机工作时,它像“投影仪”一样逐层变换图案照射生物墨水,让材料在光照下快速凝固成型。传统3D打印的材料大多是单一塑料,而生物打印需要同时处理软硬不同的墨水(如骨骼和肌肉),面临墨水残留污染、不同材料交界处容易脱落和打印微结构时精度丢失的挑战。
    该团队的创新如同为打印机装上“智能大脑”与“精密机械手”。(1)6通道“器官调色盘”自主研发的6通道同步打印平台,可同时装载6种不同类型的生物墨水(如软骨细胞、神经细胞等),通过智能操作系统精准切换。(2)“水枪+吸尘器”双重清洁。在材料切换时先用水流冲刷残留,再用微型吸尘器吸走余液,将交叉污染率控制在5% 以内。(3)界面“分子拉链”设计。通过梯度化水凝胶结构设计,让不同材料交界处形成类似拉链齿的微观互锁结构,使界面结合强度提升50%。(4)精度“质检仪”。开发的“交替辐条阵列测试模型”,可量化光固化参数、材料相互作用等因素对精度的影响,将打印误差控制在头发丝的1/2(即5 μm)以内。
    该成果为再生医学及组织工程的复杂结构制造提供了标准化的装备,能广泛应用于器官芯片、医疗器械、活体组织体外重建等前沿方向奠定了技术基础。贺永表示:“我们的目标是让生物打印机像工业级3D打印机一样稳定可靠。未来,随着更多功能性生物墨水的开发,打印出具有完整血管网络甚至神经传导功能的器官将成为可能。”
    (来源于中国科技期刊卓越行动计划入选期刊:《Research》,2025,8(0613)

    参考文献 引证文献
    排序方式:
    2025年第43卷第6期
    PDF下载
    520
    248
    引用本文
    BibTeX
    文章信息
    • 首发时间:2025-04-19
    • 出版时间:2025-03-28
    补充材料
    相关文章
    文章信息
    作者
    出版历史
    基金
    作者信息
    参考文献
    分享链接
    https://castjournals.cast.org.cn/joweb/kjdb/CN/1242142904903349219
    分享至
    全文二维码

    扫描看全文

    引用本文
    BibTeX
    本文的引用情况
    2种不同金属材料的力学参数

    Family
    属数
    Number of
    genus
    种数
    Number of
    species
    占总种数比例
    Percentage of
    total species (%)

    Genus
    种数
    Number of
    species
    占总种数比例
    Percentage of total
    species (%)
    鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
    小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
    多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
    红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
    小菇属 Mycena 11 5.26
    光柄菇属 Pluteus 5 2.39
    红菇属 Russula 17 8.13
    栓菌属 Trametes 5 2.39
    关闭全屏