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聚对苯二甲酸乙二醇酯（PET）塑料废物的积累对全球塑料污染治理构成了重大挑战。生物降解法作为一种成本低、污染少的回收处理方式，展现出了广阔的应用前景。2016年报道的IsPETase和IsMHETase双酶联用体系为在温和条件下降解PET微塑料提供了新的技术路径，其中IsPETase是降解高聚物的主要水解酶，IsMHETase则通过水解中间产物对苯二甲酸单（2-羟乙基）酯（MHET）来消除MHET对IsPETase的竞争性抑制作用。

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