Article(id=1242141963043021794, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242141260123811886, articleNumber=null, orderNo=null, doi=10.3981/j.issn.1000-7857.2024.06.00624, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1704988800000, receivedDateStr=2024-01-12, revisedDate=1719158400000, revisedDateStr=2024-06-24, acceptedDate=null, acceptedDateStr=null, onlineDate=1735142400000, onlineDateStr=2024-12-26, pubDate=1732723200000, pubDateStr=2024-11-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1735142400000, onlineIssueDateStr=2024-12-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774079321867, creator=sys-migrate, updateTime=1774079321867, updator=sys-migrate, issue=Issue{id=1242141260123811886, tenantId=1146029695717560320, journalId=1146031591421210625, year='2024', volume='42', issue='22', pageStart='1', pageEnd='108', issueExtLink='null', onlineDate='null', pubDate='1732723200000', pubDateStr='2024-11-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=null, issueType=-1, specialIssue=null, createTime=1774079154279, creator='sys-migrate', updateTime=1774079154279, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=30, endPage=42, ext={EN=ArticleExt(id=1242141966939529232, articleId=1242141963043021794, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Health promotion of γ-aminobutyric acid supplements in chronic disease population, columnId=1242141965945479168, journalTitle=Science & Technology Review, columnName=Exclusive：Anti aging and health of the elderly, runingTitle=null, highlight=null, articleAbstract=γ-aminobutyric acid (γ-amino butyric acid, GABA) is a new food supplement in China. According to current studies, foodborne GABA is believed to be able to promote health and resist various chronic diseases. In this paper, the metabolism, effects and mechanisms of food-borne and endogenous GABA in mammalian organism, and safety and content of GABA in foods were reviewed. The design and main results of human trials of exogenous GABA supplementation were summarized. Existing randomized controlled trials (RCT) show that GABA intake plays a role in neuroregulation, such as anti-anxiety and improvement of sleep disorders, and lowering blood pressure and regulating blood sugar in both patients and healthy subjects. However, the dose ranges of GABA from different sources are different, and the functional dose range of GABA from natural food supplement is lower than that of biosynthetic GABA. Due to certain design defects of the previous RCTs, quality RCT studies are needed in the future to further clarify the clinical effect of exogenous GABA., authors=DING Yi^1,2, WANG Jianing¹, DING Haitao³, AI Hua¹, authorsList=DING Yi, WANG Jianing, DING Haitao, AI Hua, authorCompany=1. Institute of Sports Medicine, Peking University Third Hospital, Beijing 100191, China;
2. Rehabilitation Hospital Affiliated to National Rehabilitation Aids Research Center, Beijing 100176, China;
3. Clinical Laboratory Medicine Center, Inner Mongolia People's Hospital, Hohhot 010017, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242141966188748807, articleId=1242141963043021794, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=食源性γ-氨基丁酸与促进慢病人群健康研究进展, columnId=1242141965182116849, journalTitle=科技导报, columnName=专题：抗衰老与老年健康, runingTitle=null, highlight=null, articleAbstract=γ-氨基丁酸（γ-amino butyric acid，GABA）在中国属于食品新资源，现阶段的研究认为食源性GABA具有促进健康、抗多种慢性疾病的功效。综述了食源性和内源性GABA在哺乳动物机体内的代谢、作用及机制、安全性以及食物中GABA含量，归纳了外源性补充GABA人体试验设计和主要结果。高质量随机对照临床研究显示，外源性摄入GABA可对患者和健康受试者发挥抗焦虑、改善睡眠障碍等神经调节及降血压、调节血糖的作用，但不同来源GABA的剂量范围不同，天然食物来源的GABA的功能剂量范围低于生物合成GABA。现有的随机对照临床试验（RCT）均存在不同程度上的设计缺陷，未来仍需更多的高质量RCT研究来明确外源性GABA的临床作用。, authors=丁一^1,2, 王佳宁¹, 丁海涛³, 艾华¹, authorsList=丁一, 王佳宁, 丁海涛, 艾华, authorCompany=1. 北京大学第三医院运动医学研究所, 北京 100191;
2. 国家康复辅具研究中心附属康复医院, 北京 100176;
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