Article(id=1242141218528899956, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242141206956815165, articleNumber=null, orderNo=null, doi=10.3981/j.issn.1000-7857.2023.03.00411, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1678896000000, receivedDateStr=2023-03-16, revisedDate=1681142400000, revisedDateStr=2023-04-11, acceptedDate=null, acceptedDateStr=null, onlineDate=1720368000000, onlineDateStr=2024-07-08, pubDate=1718208000000, pubDateStr=2024-06-13, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1720368000000, onlineIssueDateStr=2024-07-08, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774079144362, creator=sys-migrate, updateTime=1774079144362, updator=sys-migrate, issue=Issue{id=1242141206956815165, tenantId=1146029695717560320, journalId=1146031591421210625, year='2024', volume='42', issue='11', pageStart='1', pageEnd='104', issueExtLink='null', onlineDate='null', pubDate='1718208000000', pubDateStr='2024-06-13', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=null, issueType=-1, specialIssue=null, createTime=1774079141603, creator='sys-migrate', updateTime=1774079141603, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=66, endPage=74, ext={EN=ArticleExt(id=1242141222047921041, articleId=1242141218528899956, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Research progress of anti-inflammatory drugs in osteoarthritis treatment, columnId=1242116810380743325, journalTitle=Science & Technology Review, columnName=Reviews, runingTitle=null, highlight=null, articleAbstract=Osteoarthritis (OA) is the most common degenerative disease of joint, which is characterized by degeneration of articular cartilage and inflammation of articular capsule. Inflammatory reaction of articular cartilage is usually related to oxidative stress and secretion of proinflammatory cytokines in OA microenvironment. This article describes the role of inflammatory reaction in osteoarthritis and discusses the related progress in the treatment of osteoarthritis with cyclooxygenase, interleukin-1, inhibitor, prostaglandin synthetase inhibitor, and antioxidant stress drugs., authors=MA Zhiyan^1,2, HE Ziye³, LIANG Jiaming^1,2, ZHAO Linlin^1,2, ZHANG Yingyu², LIU Yingying^2,3, LIU Yajun^2,4, authorsList=MA Zhiyan, HE Ziye, LIANG Jiaming, ZHAO Linlin, ZHANG Yingyu, LIU Yingying, LIU Yajun, authorCompany=1. School of Public Health and Health Management, Shandong First Medical University, Ji'nan, 250117, China;
2. Medical Science and Technology Innovation Center, Shandong First Medical University, Ji'nan 250117, China;
3. School of Biomedical Sciences, Shandong First Medical University, Ji'nan 250117, China;
4. National Orthopaedic Medical Center, Beijing Jishuitan Hospital, Beijing Institute of Orthopaedic Trauma, Beijing 100035, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242141221435552649, articleId=1242141218528899956, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=抗炎类药物治疗骨关节炎研究进展, columnId=1242134377686180284, journalTitle=科技导报, columnName=综述, runingTitle=null, highlight=null, articleAbstract=骨关节炎（Osteoarthritis，OA）是最常见的关节退行性疾病，其主要特征是关节软骨的退化和关节囊的炎症。关节软骨炎症反应通常与 OA微环境中的氧化应激和促炎细胞因子的分泌有关。阐述了炎症反应在骨关节炎中的作用，探讨了应用环氧化酶抑制剂、白细胞介素-1抑制剂、前列腺素合成酶抑制剂等抗炎类药物治疗骨关节炎的相关研究进展。, authors=马志燕^1,2, 贺子晔³, 梁家铭^1,2, 赵琳琳^1,2, 张颖煜², 刘营营^2,3, 刘亚军^2,4, authorsList=马志燕, 贺子晔, 梁家铭, 赵琳琳, 张颖煜, 刘营营, 刘亚军, authorCompany=1. 山东第一医科大学公共卫生与健康管理学院, 济南 250117;
2. 山东第一医科大学医学科技创新中心, 济南 250117;
3. 山东第一医科大学生物医学科学学院, 济南 250117;
4. 北京积水潭医院国家骨科医学中心, 北京市创伤骨科研究所, 北京 100035, correspAuthors=null, authorNote=马志燕，硕士研究生，研究方向为骨退行性疾病，电子信箱：mzy1755@163.com；刘营营（通信作者），副教授，研究方向为骨关节炎症微环境调控及治疗，电子信箱：liuyingying@sdfmu.edu.cn；刘亚军（共同通信作者），教授，研究方向为退行性骨病的分子机制与纳米靶向治疗，电子信箱：drliuyajun@163.com, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=S/zhWTOrKVWfp0GNl1mOdg==, pdfFileSize=1614601, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=国家自然科学基金项目（92068119）；青年北京学者项目（2020-025）；北京市自然科学基金项目（L202011）；科技部人才项目（SQ2022RA2A000031）；北京市医院管理中心项目（QML20200401）)}, authors=[Author(id=1278525821728043018, tenantId=1146029695717560320, journalId=null, articleId=1242141218528899956, orderNo=null, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, 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