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无缺血器官技术移植研究进展
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科技导报 | 专题:关键技术与创新驱动 2024,42(8): 76-82
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科技导报 | 专题:关键技术与创新驱动 2024, 42(8): 76-82
无缺血器官技术移植研究进展
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李冶夫1, 张明熙2, 吴少海3, 陈宏珲2, 黄金波2, 鲁昌涛1, 姚尧1, 赵强2, 何晓顺2
作者信息
    1. 奇点医疗科技(广州)有限公司, 广州 511338;
    2. 中山大学附属第一医院, 广州 510062;
    3. 广东省医疗器械质量监督检验所, 广州 510663

通讯作者:

何晓顺(通信作者),主任医师,研究方向为无缺血器官移植,电子信箱:gdtrc@163.com
Research progress of ischemia-free organ transplantation
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出版时间: 2024-04-28 doi: 10.3981/j.issn.1000-7857.2023.12.01824
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近年来,加入移植等待名单的患者数量逐年升高,但由于供体缺乏,因此扩展标准供体(ECD)器官的利用率逐年增高。从改善病人预后、改变肝内代谢,同时避免缺血-再灌注损伤(IRI),实现肝脏活性评估并提高移植物利用率3个方面,总结了无缺血器官移植(IFOT)技术进展,展望了无缺血器官移植的发展前景。无缺血器官移植技术在未来可能会改变器官移植的方式,技术创新和可移动机器灌注设备开发使用将助推该技术的进一步发展。
无缺血器官移植  /  常温机械灌注  /  缺血-再灌注损伤  /  早期同种异体移植物功能障碍
Ischemia-reperfusion injury (IRI) is a congenital defect of organ transplantation. Extended criteria donor (ECD) organs are more susceptible to IRI, resulting in a serious contradiction between supply and demand. Although the breakthrough of machine perfusion technology has brought the hope of alleviating IRI, it still cannot eradicate the organ damage caused by IRI. Ischemia-free organ transplantation can completely avoid IRI, improve graft function, improve the prognosis of patients, and expand the source of graft. This article summarizes the latest progress of ischemia-free organ transplantation, and looks forward to the future development of ischemia-free organ transplantation, so as to help researchers and clinicians in related fields understand the latest research status of ischemia-free organ transplantation and provide reference.
ischemia-free organ transplantation(IFOT)  /  normothermic machine perfusion(NMP)  /  ischemia reperfusion injury  /  early allograft dysfunction
李冶夫, 张明熙, 吴少海, 陈宏珲, 黄金波, 鲁昌涛, 姚尧, 赵强, 何晓顺. 无缺血器官技术移植研究进展. 科技导报, 2024 , 42 (8) : 76 -82 . DOI: 10.3981/j.issn.1000-7857.2023.12.01824
LI Yefu, ZHANG Mingxi, WU Shaohai, CHEN Honghui, HUANG Jinbo, LU Changtao, YAO Yao, ZHAO Qiang, HE Xiaoshun. Research progress of ischemia-free organ transplantation[J]. Science & Technology Review, 2024 , 42 (8) : 76 -82 . DOI: 10.3981/j.issn.1000-7857.2023.12.01824
2024年第42卷第8期
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doi: 10.3981/j.issn.1000-7857.2023.12.01824
  • 接收时间:2023-12-03
  • 首发时间:2024-05-22
  • 出版时间:2024-04-28
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  • 收稿日期:2023-12-03
  • 修回日期:2024-03-15
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何晓顺(通信作者),主任医师,研究方向为无缺血器官移植,电子信箱:gdtrc@163.com
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2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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