Article(id=1242140801212428633, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242140779540459765, articleNumber=null, orderNo=14, doi=10.3981/j.issn.1000-7857.2023.23.012, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1662739200000, receivedDateStr=2022-09-10, revisedDate=1676131200000, revisedDateStr=2023-02-12, acceptedDate=null, acceptedDateStr=null, onlineDate=1703135615557, onlineDateStr=2023-12-21, pubDate=1702396800000, pubDateStr=2023-12-13, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1703135615557, onlineIssueDateStr=2023-12-21, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774079044865, creator=sys-migrate, updateTime=1774079044865, updator=sys-migrate, issue=Issue{id=1242140779540459765, tenantId=1146029695717560320, journalId=1146031591421210625, year='2023', volume='41', issue='23', pageStart='1', pageEnd='112', issueExtLink='null', onlineDate='null', pubDate='1702396800000', pubDateStr='2023-12-13', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774079039699, creator='sys-migrate', updateTime=1774079039699, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=88, endPage=99, ext={EN=ArticleExt(id=1242140805096354165, articleId=1242140801212428633, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Clinical prognostic effect of Shenfu injection on patients with septic shock: A systemic review and meta-analysis, columnId=1242140791943016734, journalTitle=Science & Technology Review, columnName=Exclusive: Era Development in Rehabilitation Medicine and Chinese Strategies, runingTitle=null, highlight=null, articleAbstract=This study aims to explore the clinical safety and efficacy of Shenfu injection combined with western medicine in the treatment of septic shock at the level of evidence-based medicine. SinoMed, Embase, PubMed and Cochrane databases were searched for randomized controlled trials (RCTs) of Shenfu injection in the treatment of septic shock, with key indicators being 28-day mortality, incidence of multiple organ dysfunction syndrome (MODS), length of ICU stay, blood lactate level and blood lactate clearance rate. Meta-analysis was performed using Review Manager 5.4 and Stata 15.0 software. A total of 43 RCTS were included. The results showed that the 28-day mortality rate (RR=0.82, 95%CI: 0.70 to 0.95) and the incidence rate of MODS (RR=0.67, 95%CI: 0.56 to 0.81), ICU length of stay (MD=-1.95, 95%CI: -2.61 to -1.30), blood lactate level at 6 hours after treatment (MD=-1.10, 95%CI: -1.47 to -0.72), and blood lactate level at 24 hours after treatment (MD=-0.87, 95%CI: -1.12 to -0.63) were all lower (P<0.001), compared with the control group (receiving conventional western medicine treatment), while the clearance rate of blood lactic acid at 24 hours after treatment in the Shenfu group (MD=9.79, 95%CI: 6.33 to 13.25) was higher. It is concluded that compared to conventional western medicine treatment, Shenfu injection can significantly reduce the 28-day mortality, the incidence of MODS, the length of ICU stay, the level of blood lactate 6 hours after treatment, the level of blood lactate 24 hours after treatment, improve the clearance rate of blood lactate 24 hours after treatment, and significantly improve the prognosis of patients with septic shock compared with conventional western medical therapy., authors=QIN Chenyuan¹, LIAO Jiaojiao², ZHANG Shimo¹, FENG Yuting³, LIU Jue¹, TAO Liyuan^2*, authorsList=QIN Chenyuan, LIAO Jiaojiao, ZHANG Shimo, FENG Yuting, LIU Jue, TAO Liyuan, authorCompany=1. School of Public Health, Peking University, Beijing 100191, China
2. Clinical Epidemiology Research Center, Peking University Third Hospital, Beijing 100191, China
3. Evidence Based Medicine Center, Beijing University of Chinese Medicine, Beijing, 100191, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=xSt5W5vsxX494obrEEbGmA==, pdfFileSize=3754410, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242140803959697767, articleId=1242140801212428633, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=参附注射液治疗脓毒性休克预后的系统综述及荟萃分析, columnId=1242140790793777430, journalTitle=科技导报, columnName=专题：康复医学的时代发展与中国策略, runingTitle=null, highlight=null, articleAbstract=在循证医学层面探究在西医治疗基础上联合应用参附注射液治疗脓毒性休克的临床安全性和有效性。SinoMed、Embase、PubMed、Cochrane数据库中查找关于参附注射液治疗脓毒性休克的随机对照试验（RCTs），关键指标为28 d病死率、多器官功能障碍综合征（MODS）发生率、ICU住院天数、血乳酸水平和血乳酸清除率，荟萃分析使用的软件为Review Manager 5.4 和 Stata 15.0。Meta 分析共纳入 43 项 RCTs，结果显示，与对照组（接受常规西医治疗）相比，参附组（参附注射液联合常规西医治疗）脓毒性休克患者28 d病死率（RR=0.82，95%CI：0.70~0.95）、MODS发生率（RR=0.67，95%CI：0.56~0.81）、ICU住院天数（MD=−1.95，95%CI：−2.61~−1.30）、治疗后6 h的血乳酸水平（MD=−1.10，95%CI：−1.47~−0.72）、治疗后24 h的血乳酸水平（MD=-0.87，95%CI：−1.12~−0.63）均更低（均 P<0.001），而参附组治疗后24 h血乳酸清除率（MD=9.79，95%CI：6.33~13.25）高于对照组（P<0.001）。得出结论：循证医学证据显示，相较于常规西医疗法，联合应用参附注射液可显著降低脓毒性休克患者28 d病死率、MODS发生率、ICU住院天数、治疗后6 h的血乳酸水平、治疗后24 h的血乳酸水平，提高治疗后24 h的血乳酸清除率，显著改善患者预后。, authors=秦宸媛¹，廖姣姣²，张石默¹，冯玉婷³，刘珏¹，陶立元^2*, authorsList=秦宸媛，廖姣姣，张石默，冯玉婷，刘珏，陶立元, authorCompany=1. 北京大学公共卫生学院，北京 100191
2. 北京大学第三医院临床流行病学研究中心，北京 100191
3. 北京中医药大学循证医学中心，北京 100191, correspAuthors=null, authorNote=秦宸媛，博士研究生，研究方向为健康大数据应用，电子信箱：qincy@bjmu.edu.cn；廖姣姣（共同第一作者），硕士研究生，研究方向为临床研究方法学，电子信箱：lelia_lj@163.com, correspAuthorsNote=陶立元（通信作者），研究员，研究方向为中医药疗效评价方法学、临床流行病学、生物统计学和循证医学，电子信箱：tendytly@163.com, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=DPGJf3liMXJxCaPGggD2tg==, pdfFileSize=3754410, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=国家自然科学基金项目（82004210）)}, authors=null, keywords=[Keyword(id=1242140803515097844, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242140801212428633, language=CN, orderNo=1, keyword=循证医学), Keyword(id=1242140803607372535, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242140801212428633, language=CN, 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