Article(id=1242140654898323570, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242140642726453284, articleNumber=null, orderNo=10, doi=10.3981/j.issn.1000-7857.2023.18.008, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1685030400000, receivedDateStr=2023-05-26, revisedDate=1685030400000, revisedDateStr=2023-05-26, acceptedDate=null, acceptedDateStr=null, onlineDate=1695891207993, onlineDateStr=2023-09-28, pubDate=1695830400000, pubDateStr=2023-09-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1695891207993, onlineIssueDateStr=2023-09-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774079009982, creator=sys-migrate, updateTime=1774079009982, updator=sys-migrate, issue=Issue{id=1242140642726453284, tenantId=1146029695717560320, journalId=1146031591421210625, year='2023', volume='41', issue='18', pageStart='1', pageEnd='108', issueExtLink='null', onlineDate='null', pubDate='1695830400000', pubDateStr='2023-09-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774079007081, creator='sys-migrate', updateTime=1774079007081, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=58, endPage=66, ext={EN=ArticleExt(id=1242140658757083282, articleId=1242140654898323570, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Advances of subsequent therapeutic strategies to overcome resistance to CDK4/6 inhibitors in breast cancer and its mechanisms, columnId=1242140650540441700, journalTitle=Science & Technology Review, columnName=Exclusive：Cancer prevention and cure, runingTitle=null, highlight=null, articleAbstract=This article provided an overview of current therapeutic strategies to overcome CDK4/6 inhibitor resistance in breast cancer and analyzed the clinical findings of CDK4/6 inhibitor cross-line therapy, novel oral SERDs, PI3K/AKT/mTOR inhibitors, ADC drugs, AURKA inhibitors, HDAC inhibitors, immunotherapeutic strategies and anti-senescence therapies after CDK4/6 inhibitor progression and the related mechanisms. Furthermore, we prospected the potential targets for clinical studies in the future., authors=MA Jiayi, YIN Wenjin, WU Ziping, LU Jingsong^*, authorsList=MA Jiayi, YIN Wenjin, WU Ziping, LU Jingsong, authorCompany=Department of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=jn3GgnzcsgwcenGZ6cIyJA==, pdfFileSize=539953, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242140657725289189, articleId=1242140654898323570, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=CDK4/6抑制剂耐药乳腺癌处理策略及其机制研究进展, columnId=1242140649575751762, journalTitle=科技导报, columnName=专题：癌症防治, runingTitle=null, highlight=null, articleAbstract=概述了CDK4/6抑制剂耐药乳腺癌的治疗策略，分析了CDK4/6抑制剂跨线治疗、新型口服SERDs药物、PI3K/AKT/mTOR抑制剂、ADC类药物、AURKA抑制剂、HDAC抑制剂、免疫治疗和抗衰老药物在CDK4/6抑制剂进展后的临床研究结果及其相关机制。展望未来，可开展更多临床研究的潜在靶点。, authors=马嘉忆，殷文瑾，吴子平，陆劲松^*, authorsList=马嘉忆，殷文瑾，吴子平，陆劲松, authorCompany=上海交通大学医学院附属仁济医院乳腺外科，上海 200127, correspAuthors=null, authorNote=马嘉忆，博士研究生，研究方向为乳腺癌内分泌治疗耐药机制及其应对策略，电子信箱：longestma@163.com, correspAuthorsNote=陆劲松（通信作者），主任医师，研究方向为乳腺癌的临床与基础，电子信箱：lujingsong@renji.com, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=8cIxOUEyzz1UsJbqXDASNg==, pdfFileSize=539953, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=北京医学奖励基金会项目（YXJL-2020-0941-0737）)}, authors=null, keywords=[Keyword(id=1242140655913345143, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242140654898323570, language=CN, orderNo=1, keyword=细胞周期蛋白依赖性激酶4/6抑制剂), Keyword(id=1242140657402327776, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242140654898323570, language=CN, orderNo=1, keyword=晚期乳腺癌), Keyword(id=1242140657473630946, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242140654898323570, language=CN, orderNo=1, keyword=耐药机制), Keyword(id=1242140657561711331, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242140654898323570, language=CN, orderNo=1, keyword=内分泌治疗), Keyword(id=1242140658362823399, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242140654898323570, language=EN, orderNo=1, keyword=cyclin-dependent kinase 4/6 inhibitor), Keyword(id=1242140658434126568, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242140654898323570, language=EN, orderNo=1, keyword=advanced breast cancer), Keyword(id=1242140658501235433, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242140654898323570, language=EN, orderNo=1, keyword=mechanisms of drug resistance), Keyword(id=1242140658593510122, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242140654898323570, language=EN, orderNo=1, keyword=endocrine therapy)], refs=null, funds=null, companyList=null, figs=null, attaches=null, journal=Journal(id=1125356956822126595, delFlag=0, nameCn=科技导报, nameEn=Science & Technology Review, nameHistory1=null, nameHistory2=null, issn=1000-7857, eissn=, cn=11-1421/N, coden=null, periodic=3, language=CN, oaType=0, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=wfghvu3bhh/dKxuZ+ucVHA==, journalPrice=null, startedYear=null, abbrevIsoEn=Sci Technol Rev, journalRemark=null, publicationField=null, createdTime=null, updatedTime=1774230116083, createdBy=null, updatedBy=13041195026, firstLetterCn=S, firstLetterEn=S, subjectCode=Natural Sciences, subjectName=自然科学, subjectCodeEn=Natural Sciences, subjectNameEn=null, picCn=wfghvu3bhh/dKxuZ+ucVHA==, picEn=yjSfclmpNm7ihn9NbTZ69g==, jcr=null, cjcr=null, exts=[JournalExt(id=1242774439910290156, language=CN, name=科技导报, nameHistory1=null, nameHistory2=null, managedBy=中国科学技术协会, sponsoredBy=中国科学技术协会, publishedBy=科技导报社, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=http://www.kjdb.org/CN/home, createdTime=1774230116107, updatedTime=1774230116107, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=http://www.kjdb.org/CN/column/column7.shtml, submissionAuthorUrl=https://kjdbauthor.cast.org.cn/webm, submissionEditorUrl=https://kjdbeditor.cast.org.cn/webm/, submissionReviewUrl=https://kjdbauthor.cast.org.cn/webm, submissionCeEditorUrl=https://kjdbeditor.cast.org.cn/webm/, submissionAeEditorUrl=https://kjdbeditor.cast.org.cn/webm/, option={"copyright":""}), JournalExt(id=1242774439960621805, language=EN, name=Science & Technology Review, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=http://www.kjdb.org/EN/home, createdTime=1774230116119, updatedTime=1774230116119, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=http://www.kjdb.org/EN/column/column7.shtml, submissionAuthorUrl=https://kjdbauthor.manuscriptcloud.com/login, submissionEditorUrl=https://kjdbeditor.manuscriptcloud.com/login, submissionReviewUrl=https://kjdbauthor.manuscriptcloud.com/login, submissionCeEditorUrl=https://kjdbeditor.manuscriptcloud.com/login, submissionAeEditorUrl=https://kjdbeditor.manuscriptcloud.com/login, option={"copyright":""})], databaseList=null, tenantJournalId=1146031591421210625, websiteList=[Website(id=1146104741081231361, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1146031591421210625, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/kjdb/CN, language=CN, createTime=1751182263881, createBy=18614031015, updateTime=1751778001962, updateBy=18614031015, name=科技导报, tplId=1146099689490845704, title=科技导报, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1148021146403992296, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=articleTextType, value=kx, createTime=1751639170504, updateTime=1751639170504, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146378826469, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=banner, value=null, createTime=1751639170498, updateTime=1751639170498, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146366243556, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=logo, value=https://castjournals.cast.org.cn/joweb/kjdb/CN/file/pic?fileId=9GHSf7eGlIPH0Tv/OOdstA==, createTime=1751639170495, updateTime=1751639170495, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146395603687, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/kjdb/CN/file/pic, createTime=1751639170502, updateTime=1751639170502, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146387215078, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1751639170500, updateTime=1751639170500, creator=18614031015, updator=18614031015)]), Website(id=1146105254833139715, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1146031591421210625, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/kjdb/EN, language=EN, createTime=1751182386363, createBy=18614031015, updateTime=1753500121937, updateBy=18614031015, name=科技导报, tplId=1146101810881728533, title=Science & Technology Review, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1155838567709528217, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=articleTextType, value=kx, createTime=1753502988984, updateTime=1753502988984, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567692750998, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=banner, value=null, createTime=1753502988980, updateTime=1753502988980, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567688556693, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=logo, value=https://castjournals.cast.org.cn/joweb/kjdb/EN/file/pic?fileId=9GHSf7eGlIPH0Tv/OOdstA==, createTime=1753502988979, updateTime=1753502988979, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567705333912, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/kjdb/EN/file/pic, createTime=1753502988983, updateTime=1753502988983, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567701139607, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1753502988982, updateTime=1753502988982, creator=18614031015, updator=18614031015)])], journalTitle=科技导报, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Science & Technology Review, journalPhotoCn=wfghvu3bhh/dKxuZ+ucVHA==, journalPhotoEn=yjSfclmpNm7ihn9NbTZ69g==, journalFirstLetter=S, journalRecommend=null, journalNew=null, journalCollection=1, jcrJf=null, cjcrJf=0.91, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=null, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/kjdb/CN/10.3981/j.issn.1000-7857.2023.18.008, detailUrlEn=https://castjournals.cast.org.cn/joweb/kjdb/EN/10.3981/j.issn.1000-7857.2023.18.008, pdfUrlCn=https://castjournals.cast.org.cn/joweb/kjdb/CN/PDF/10.3981/j.issn.1000-7857.2023.18.008, pdfUrlEn=https://castjournals.cast.org.cn/joweb/kjdb/EN/PDF/10.3981/j.issn.1000-7857.2023.18.008, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1695830400000, fullTextJson=null, articleText=null, reference=null)