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2. Peking University School and Hospital of Stomatology, Beijing 100081, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=hdaWrtPS+CwaOU6ZbxptJw==, pdfFileSize=1896474, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242140479333151604, articleId=1242140476569105256, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=全球抗肿瘤抗体药物研究热点分析, columnId=1242134377686180284, journalTitle=科技导报, columnName=综述, runingTitle=null, highlight=null, articleAbstract=分析了近10年全球抗肿瘤单克隆抗体核心文献的研究主题，通过研究主题的演变揭示领域发展趋势，确定近年来7个热点研究方向。通过专业数据库及机构网站对具体热点方向进行深度分析，挖掘国内外处于临床试验阶段及已上市药品的靶点、作用机制等相关信息。研究发现，已上市抗体药物有效性和安全性监测及药物联用、双特异性抗体及抗体药物偶联物等新型抗体药物研发，以及以 4-1BB为代表的新靶点开发是近年来的研究热点和重点。中国应加强对上市药品的不良事件监测，加大力度支持新型抗体药物的研发。, authors=张巍巍¹，管同¹，徐励²，李春英^1*, authorsList=张巍巍，管同，徐励，李春英, authorCompany=1. 北京大学医学图书馆，北京 100191
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