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2. Biotherapy Center of the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=ZTbyqAcpnbqBprzb/0auAA==, pdfFileSize=444632, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242140261531333566, articleId=1242140259962663858, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=2022年肿瘤免疫研究热点回眸, columnId=1242140248948417060, journalTitle=科技导报, columnName=专题：2022年科技热点回眸, runingTitle=null, highlight=null, articleAbstract=肿瘤免疫治疗已成为继手术、放疗、化疗之后的第四类肿瘤治疗方法，为当今国际研究的热点领域。在肿瘤免疫治疗新时代，以免疫检查点抑制剂、基因工程化修饰免疫细胞为代表的免疫疗法被认为具有广阔前景。概述了2022年肿瘤免疫治疗领域研究的热点及关键进展，包括嵌合抗原受体T细胞（CAR-T）在实体瘤治疗中的突破、维持记忆性T细胞生存和功能新机制的发现、改善肿瘤免疫抑制微环境提高免疫治疗疗效的深入探究以及瘤内微生物对抗肿瘤免疫反应的重要影响作用。, authors=黄波¹, 张毅², authorsList=黄波, 张毅, authorCompany=1. 中国医学科学院北京协和医学院免疫学系, 北京 100730;
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