Article(id=1242139928440680817, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242139926238667771, articleNumber=null, orderNo=6, doi=10.3981/j.issn.1000-7857.2022.12.004, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1652976000000, receivedDateStr=2022-05-20, revisedDate=1655222400000, revisedDateStr=2022-06-15, acceptedDate=null, acceptedDateStr=null, onlineDate=1659694399567, onlineDateStr=2022-08-05, pubDate=1656345600000, pubDateStr=2022-06-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1659694399567, onlineIssueDateStr=2022-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774078836780, creator=sys-migrate, updateTime=1774078836780, updator=sys-migrate, issue=Issue{id=1242139926238667771, tenantId=1146029695717560320, journalId=1146031591421210625, year='2022', volume='40', issue='12', pageStart='0', pageEnd='136', issueExtLink='null', onlineDate='null', pubDate='1656345600000', pubDateStr='2022-06-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774078836256, creator='sys-migrate', updateTime=1774078836256, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=42, endPage=52, ext={EN=ArticleExt(id=1242139931481551244, articleId=1242139928440680817, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Applications of organoids-on-a-chip in disease models in vitro , columnId=1242139930009350520, journalTitle=Science & Technology Review, columnName=Exclusive：Organoids, runingTitle=null, highlight=null, articleAbstract=To gain a better insight into the mechanisms of the human disease calls for stable and reliable in vitro and in vivo models to reproduce the physiological and pathophysiological processes of human tissues and organs. Cellular and animal models provide critical tools for modeling the human condition, but due to the deficiencies of these methods, we may fail to comprehend the human diseases accurately. Organoids originate from the stem cells based on the cellular self-organization and development principles, and are similar to the native organs in structure and functions. However, most organoids can not mimic the functions of the mature organs due to lacking controllable biochemical and biophysical stimulations. Organ-on-a-Chip is an emerging cutting-edge technology in the last decade by culturing multiple cells on the microfluidic chips to model the physiological and pathological microenvironments of the organs veritably. This technology provides three dimensional microphysiological systems with the tissue-tissue interface and the multiple physicochemical stimulations. Organoid-on-a-Chips, the integration of the organoids with the organ-on-a-chip technology, provide a better biomimetic environment for the traditional organoid culture system and avoid the shortage of the conventional organoid technology. The organoid-on-a-Chip technology promises to be a potential in vitro disease model. In this review, we focus on the construction of disease models on the organoid-on-a-chip and the research advances in the disease mechanism. We also discuss the current obstacles and the future trend of this technology., authors=WANG Li1 , LUO Shaman1 , ZHANG Miao2 , WEI Wenbo2 , QIU Junjun3 , authorsList=WANG Li, LUO Shaman, ZHANG Miao, WEI Wenbo, QIU Junjun, authorCompany=1. Institutes of Biomedical Sciences and the Shanghai Key Laboratory of Medical Epigenetics, Shanghai Medical College, Fudan University, Shanghai 200032, China;1 , 骆沙曼1 , 张淼2 , 魏文博2 , 邱君君3 , authorsList=王丽, 骆沙曼, 张淼, 魏文博, 邱君君, authorCompany=1. 复旦大学生物医学研究院, 上海 200032;
科技导报
| 专题：类器官 2022, 40(12): 42-52
类器官芯片在疾病体外模型中的应用
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王丽, 骆沙曼, 张淼, 魏文博, 邱君君
作者信息
通讯作者:
魏文博(通信作者),助理研究员,研究方向为微流控与器官芯片技术在生物医学工程领域应用,电子信箱:wwb1004@hotmail.com;邱君君(共同通信作者),副主任医师,研究方向为妇科肿瘤,电子信箱:qiujunjun1113@163.com
Applications of organoids-on-a-chip in disease models in vitro
WANG Li, LUO Shaman, ZHANG Miao, WEI Wenbo, QIU Junjun
Affiliations
出版时间: 2022-06-28
doi: 10.3981/j.issn.1000-7857.2022.12.004
文章导航
类器官芯片是利用器官芯片独有的优势，体外构建类器官可控的理化微环境，使得类器官更能反应来源组织器官的结构和功能，从而更好地模拟器官的生理和疾病状态，是目前最具潜力的疾病体外模型之一。概述了传统类器官、器官芯片以及类器官芯片在疾病体外模型构建中的应用进展，提出了类器官芯片在疾病模型构建中存在的问题及可能解决的方案。
器官芯片
/
类器官芯片
/
微流控
/
疾病模型
/
个性化治疗
To gain a better insight into the mechanisms of the human disease calls for stable and reliable in vitro and in vivo models to reproduce the physiological and pathophysiological processes of human tissues and organs. Cellular and animal models provide critical tools for modeling the human condition, but due to the deficiencies of these methods, we may fail to comprehend the human diseases accurately. Organoids originate from the stem cells based on the cellular self-organization and development principles, and are similar to the native organs in structure and functions. However, most organoids can not mimic the functions of the mature organs due to lacking controllable biochemical and biophysical stimulations. Organ-on-a-Chip is an emerging cutting-edge technology in the last decade by culturing multiple cells on the microfluidic chips to model the physiological and pathological microenvironments of the organs veritably. This technology provides three dimensional microphysiological systems with the tissue-tissue interface and the multiple physicochemical stimulations. Organoid-on-a-Chips, the integration of the organoids with the organ-on-a-chip technology, provide a better biomimetic environment for the traditional organoid culture system and avoid the shortage of the conventional organoid technology. The organoid-on-a-Chip technology promises to be a potential in vitro disease model. In this review, we focus on the construction of disease models on the organoid-on-a-chip and the research advances in the disease mechanism. We also discuss the current obstacles and the future trend of this technology.
organ-on-a-chip
/
organoid-on-a-chip
/
microfluidics
/
disease models
/
personalized treatment
王丽, 骆沙曼, 张淼, 魏文博, 邱君君.
类器官芯片在疾病体外模型中的应用.
科技导报,
2022
, 40
(12)
: 42
-52
.
DOI: 10.3981/j.issn.1000-7857.2022.12.004
WANG Li, LUO Shaman, ZHANG Miao, WEI Wenbo, QIU Junjun.
Applications of organoids-on-a-chip in disease models in vitro [J].
Science & Technology Review ,
2022
, 40
(12)
: 42
-52
.
DOI: 10.3981/j.issn.1000-7857.2022.12.004
2022年第40卷第12期
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文章信息
doi: 10.3981/j.issn.1000-7857.2022.12.004
接收时间：2022-05-20
首发时间：2022-08-05
出版时间：2022-06-28
收稿日期：2022-05-20
修回日期：2022-06-15
通讯作者:
魏文博(通信作者),助理研究员,研究方向为微流控与器官芯片技术在生物医学工程领域应用,电子信箱:wwb1004@hotmail.com;邱君君(共同通信作者),副主任医师,研究方向为妇科肿瘤,电子信箱:qiujunjun1113@163.com
https://castjournals.cast.org.cn/joweb/kjdb/CN/10.3981/j.issn.1000-7857.2022.12.004
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2种不同金属材料的力学参数
科 属数 种数 占总种数比例 属 种数 占总种数比例 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
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