Article(id=1242139928004473200, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242139926238667771, articleNumber=null, orderNo=4, doi=10.3981/j.issn.1000-7857.2022.12.002, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1653926400000, receivedDateStr=2022-05-31, revisedDate=1655222400000, revisedDateStr=2022-06-15, acceptedDate=null, acceptedDateStr=null, onlineDate=1659694399567, onlineDateStr=2022-08-05, pubDate=1656345600000, pubDateStr=2022-06-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1659694399567, onlineIssueDateStr=2022-08-05, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774078836675, creator=sys-migrate, updateTime=1774078836675, updator=sys-migrate, issue=Issue{id=1242139926238667771, tenantId=1146029695717560320, journalId=1146031591421210625, year='2022', volume='40', issue='12', pageStart='0', pageEnd='136', issueExtLink='null', onlineDate='null', pubDate='1656345600000', pubDateStr='2022-06-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774078836256, creator='sys-migrate', updateTime=1774078836256, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=13, endPage=27, ext={EN=ArticleExt(id=1242139930768519556, articleId=1242139928004473200, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=History and prospect of organoids research, columnId=1242137384486249344, journalTitle=Science & Technology Review, columnName=Special to S&T Review, runingTitle=null, highlight=null, articleAbstract=The traditional monolayer cell cultures (cell lines) have been widely used, however, such models fail to recapitulate the cellular heterogeneity, the structure, and the functions of the primary tissues. The organoids, which are tiny, self-organized three-dimensional tissue cultures derived from the stem cells, possess the histological features and the physiological functions highly similar to those of the deriving organs. The patient-derived organoid models have excellent characteristics, such as the humanization, the personalization, the good simulation ability, and the self-organization. Recent research advances show that the organoid models have served as a promising tool in three scenarios, namely, the personalized drug response prediction, the new drug development, and the organoid biobank. The organoid technologies refer to a series of organoid model-related technologies that have a wide range of application prospects in various aspects, for instance, the developmental biology, the regenerative medicine, the disease research, the drug development, and the precision medicine, with high social and economic benefits at the same time. Therapeutic products developed based on the organoid techniques can help achieve precision medicine. Currently, the trends of the organoid technology are influenced by a combination of four factors, specifically, the demand and challenge drivers, the technology and knowledge drivers, the resource and factor drivers, and the ethical and regulatory constraints. This paper discusses the research history and the development trends, focusing on the advantages, the limitations, and the potential applications of organoid models and technologies., authors=HE Kangxin1,2 , ZHANG Jingyu1 , QIAN Jingjing2 , LI Lanjuan1,2 , authorsList=HE Kangxin, ZHANG Jingyu, QIAN Jingjing, LI Lanjuan, authorCompany=1. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China;1,2 , 张景语1 , 钱菁菁2 , 李兰娟1,2 , authorsList=何康信, 张景语, 钱菁菁, 李兰娟, authorCompany=1. 浙江大学医学院附属第一医院传染病诊治国家重点实验室, 国家感染性疾病临床医学研究中心, 国家传染病医学中心, 感染性疾病诊治协同创新中心, 杭州 310003;
科技导报
| 专稿 2022, 40(12): 13-27
人源类器官研究历程及发展趋势
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何康信1,2 , 张景语1 , 钱菁菁2 , 李兰娟1,2
作者信息
1. 浙江大学医学院附属第一医院传染病诊治国家重点实验室, 国家感染性疾病临床医学研究中心, 国家传染病医学中心, 感染性疾病诊治协同创新中心, 杭州 310003;
通讯作者:
李兰娟(通信作者),中国工程院院士,教授,研究方向为传染病学,电子信箱:ljli@zju.edu.cn
History and prospect of organoids research
Affiliations
出版时间: 2022-06-28
doi: 10.3981/j.issn.1000-7857.2022.12.002
文章导航
类器官是干细胞在体外培养出的一种3D细胞培养物（类器官模型），拥有与来源器官（组织）高度相似的组织学特征和生理功能。概述了类器官技术的发展历程、类器官的不同种类、来源及表型。以肿瘤药物开发的临床前模型为例，对比了肿瘤细胞系、条件重编程、类器官模型及荷瘤模型（PDX）这4种模型，得出类器官模型是较为优秀的一种体外模型，可用于感染性疾病和慢性非感染性疾病的模型研究。总结了类器官技术未来发展的4方面影响因素：需求和挑战的驱动、技术和知识的驱动、资源和要素的驱动、伦理和法规的约束。
The traditional monolayer cell cultures (cell lines) have been widely used, however, such models fail to recapitulate the cellular heterogeneity, the structure, and the functions of the primary tissues. The organoids, which are tiny, self-organized three-dimensional tissue cultures derived from the stem cells, possess the histological features and the physiological functions highly similar to those of the deriving organs. The patient-derived organoid models have excellent characteristics, such as the humanization, the personalization, the good simulation ability, and the self-organization. Recent research advances show that the organoid models have served as a promising tool in three scenarios, namely, the personalized drug response prediction, the new drug development, and the organoid biobank. The organoid technologies refer to a series of organoid model-related technologies that have a wide range of application prospects in various aspects, for instance, the developmental biology, the regenerative medicine, the disease research, the drug development, and the precision medicine, with high social and economic benefits at the same time. Therapeutic products developed based on the organoid techniques can help achieve precision medicine. Currently, the trends of the organoid technology are influenced by a combination of four factors, specifically, the demand and challenge drivers, the technology and knowledge drivers, the resource and factor drivers, and the ethical and regulatory constraints. This paper discusses the research history and the development trends, focusing on the advantages, the limitations, and the potential applications of organoid models and technologies.
organoid model
/
organoids techniques
/
organoids biobank
何康信, 张景语, 钱菁菁, 李兰娟.
人源类器官研究历程及发展趋势.
科技导报,
2022
, 40
(12)
: 13
-27
.
DOI: 10.3981/j.issn.1000-7857.2022.12.002
HE Kangxin, ZHANG Jingyu, QIAN Jingjing, LI Lanjuan.
History and prospect of organoids research[J].
Science & Technology Review ,
2022
, 40
(12)
: 13
-27
.
DOI: 10.3981/j.issn.1000-7857.2022.12.002
2022年第40卷第12期
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文章信息
doi: 10.3981/j.issn.1000-7857.2022.12.002
接收时间：2022-05-31
首发时间：2022-08-05
出版时间：2022-06-28
收稿日期：2022-05-31
修回日期：2022-06-15
通讯作者:
李兰娟(通信作者),中国工程院院士,教授,研究方向为传染病学,电子信箱:ljli@zju.edu.cn
https://castjournals.cast.org.cn/joweb/kjdb/CN/10.3981/j.issn.1000-7857.2022.12.002
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2种不同金属材料的力学参数
科 属数 种数 占总种数比例 属 种数 占总种数比例 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
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