Article(id=1242139643236397404, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242139619668603157, articleNumber=null, orderNo=10, doi=10.3981/j.issn.1000-7857.2022.01.008, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1640361600000, receivedDateStr=2021-12-25, revisedDate=1641052800000, revisedDateStr=2022-01-02, acceptedDate=null, acceptedDateStr=null, onlineDate=1645161084237, onlineDateStr=2022-02-18, pubDate=1642003200000, pubDateStr=2022-01-13, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1645161084237, onlineIssueDateStr=2022-02-18, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774078768778, creator=sys-migrate, updateTime=1774078768778, updator=sys-migrate, issue=Issue{id=1242139619668603157, tenantId=1146029695717560320, journalId=1146031591421210625, year='2022', volume='40', issue='1', pageStart='1', pageEnd='236', issueExtLink='null', onlineDate='null', pubDate='1642003200000', pubDateStr='2022-01-13', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774078763163, creator='sys-migrate', updateTime=1774078763163, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=132, endPage=149, ext={EN=ArticleExt(id=1242139645882999773, articleId=1242139643236397404, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Retrospect and prospect of SARS-CoV-2 in 2021: Genetic mutation, cross-species transmission, and vaccine and drug in the COVID-19 pandemic, columnId=1242139626496930098, journalTitle=Science & Technology Review, columnName=Exclusive: Science and Technology Review in 2021, runingTitle=null, highlight=null, articleAbstract=In this review we address the classification, spatiotemporal distribution, and prevalence characteristics of SARS-CoV-2 variants, followed by a description of key mutations and their biological functions in virus variants. We also summarize the novel understandings on genetic origins and interspecies transmission risk of SARS-CoV-2 between humans and animals in 2021. Next, we describe the development and effectiveness of current vaccines and antiviral drugs in 2021, and the potential virus evolution under the pressure of insufficient immune protection provided by current vaccines. In the end, we put forward targeted suggestions on pandemic control, virus surveillance, and the development of highly effective vaccines and drugs., authors=YANG Jing¹, RONG Wenwan^1,2, HUAN Yu^1,2, GONG Yuhuan^1,2, BI Yuhai^1,2, authorsList=YANG Jing, RONG Wenwan, HUAN Yu, GONG Yuhuan, BI Yuhai, authorCompany=1. Center for Influenza Research and Early-warning (CASCIRE), CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;
2. University of Chinese Academy of Sciences, Beijing 100049, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=UmIPvU37jcxkiMkI/8skug==, pdfFileSize=1882406, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242139645010588006, articleId=1242139643236397404, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=2021年新冠病毒变异、跨种传播及疫苗和药物研究热点回眸, columnId=1242139624211034407, journalTitle=科技导报, columnName=专题：2021年科技热点回眸, runingTitle=null, highlight=null, articleAbstract=概括了新冠病毒主要变异毒株的分类、时空分布和流行动态，以及关键变异位点和其对病毒生物学特性的影响；阐述了2021年新冠病毒基因进化起源研究进展和新冠病毒在人和动物间跨种传播的风险；论述了2021年新冠疫苗和药物的研发和使用现状，以及不完全免疫保护形势下病毒可能的变异动向；提出了疫情防控、病毒流行监测和疫苗药物研发的相应建议。, authors=杨婧¹, 荣文婉^1,2, 桓瑜^1,2, 龚玉环^1,2, 毕玉海^1,2, authorsList=杨婧, 荣文婉, 桓瑜, 龚玉环, 毕玉海, authorCompany=1. 中国科学院流感研究与预警中心, 中国科学院微生物研究所, 病原微生物与免疫学重点实验室, 北京 100101;
2. 中国科学院大学, 北京 100049, correspAuthors=null, authorNote=杨婧,博士,研究方向为病毒遗传演变与传播机制,电子信箱:yangj@im.ac.cn, correspAuthorsNote=毕玉海(通信作者),研究员,研究方向为病毒的跨种传播机制与生物安全防控,电子信箱:beeyh@im.ac.cn, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=OcKL8ngWaQopTgvVNOfg6A==, pdfFileSize=1882406, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=国家重点研发计划项目（2021YFC2301300）；国家自然科学基金专项（32041010，82161148010）；国家自然科学基金优秀青年科学基金项目（31822055）；中国博士后科学基金项目（2020T130123ZX）；中国科学院青年创新促进会项目（2017122）；国家病原微生物资源库项目)}, authors=null, keywords=[Keyword(id=1242139644645683554, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242139643236397404, language=CN, orderNo=1, keyword=新型冠状病毒), Keyword(id=1242139644725375331, tenantId=1146029695717560320, 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