Article(id=1242139629751710012, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242139619668603157, articleNumber=null, orderNo=7, doi=10.3981/j.issn.1000-7857.2022.01.005, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1638460800000, receivedDateStr=2021-12-03, revisedDate=1640880000000, revisedDateStr=2021-12-31, acceptedDate=null, acceptedDateStr=null, onlineDate=1645161084237, onlineDateStr=2022-02-18, pubDate=1642003200000, pubDateStr=2022-01-13, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1645161084237, onlineIssueDateStr=2022-02-18, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774078765566, creator=sys-migrate, updateTime=1774078765566, updator=sys-migrate, issue=Issue{id=1242139619668603157, tenantId=1146029695717560320, journalId=1146031591421210625, year='2022', volume='40', issue='1', pageStart='1', pageEnd='236', issueExtLink='null', onlineDate='null', pubDate='1642003200000', pubDateStr='2022-01-13', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774078763163, creator='sys-migrate', updateTime=1774078763163, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=96, endPage=112, ext={EN=ArticleExt(id=1242139636957520819, articleId=1242139629751710012, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Review of research focuses on bioscience in 2021, columnId=1242139626496930098, journalTitle=Science & Technology Review, columnName=Exclusive: Science and Technology Review in 2021, runingTitle=null, highlight=null, articleAbstract=Human activities in the broad area of sci-tech research have continued despite the still rampant global COVID-19 pandemic. In the past 2021, significant progress was made in bioscience and many related disciplines. This review highlights a few breakthroughs that directly addressed both immediate and long term needs of humans in facing those contingent and constant challenges. Specifically, we briefly present to the reader the progress made in the fields of theoretical and practical structure biology, chemical biology, COVID-19 antibody development, application of gene editing techniques, drug treatment for human mental disorders and development in imaging techniques. 2021 will be remembered for those Chinese scientists who made their particular contributions to the frontier research., authors=JIANG Jiayan^1,2, ZHU Fang^2,3, LI Cong^1,2, WANG Chengcheng³, HU Ronggui^1,2, authorsList=JIANG Jiayan, ZHU Fang, LI Cong, WANG Chengcheng, HU Ronggui, authorCompany=1. Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China;
2. Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Shanghai 200032, China;
3. Medical School, Guizhou University, Guiyang 550025, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=Gan9CqZRMGiC4igAQj+7vw==, pdfFileSize=3649775, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242139635741172648, articleId=1242139629751710012, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=2021年生命科学热点回眸, columnId=1242139624211034407, journalTitle=科技导报, columnName=专题：2021年科技热点回眸, runingTitle=null, highlight=null, articleAbstract=全球科学家在新冠病毒疫情的巨大挑战中从未停止生命科学研究的步伐，2021年生命科学及相关学科仍然取得了长足的进展。概述了2021年生命科学领域最具代表性的若干项前沿研究，对蛋白质结构预测、膜蛋白结构解析、转录起始复合物的解析、人工合成淀粉、新冠病毒中和抗体、基因编辑与疾病治疗、体外胚胎培养、迷幻药与精神疾病治疗、新型干涉单分子定位显微镜和第二代微型化双光子显微镜的研发等研究及技术领域的突破进行梳理和回顾。, authors=蒋嘉彦^1,2, 朱芳^2,3, 李聪^1,2, 王呈呈³, 胡荣贵^1,2, authorsList=蒋嘉彦, 朱芳, 李聪, 王呈呈, 胡荣贵, authorCompany=1. 中国科学院大学杭州高等研究院, 杭州 310024;
2. 中国科学院大学分子细胞科学卓越创新研究中心, 上海 200032;
3. 贵州大学医学院, 贵阳 550025, correspAuthors=null, authorNote=蒋嘉彦,硕士研究生,研究方向为蛋白质稳态与人类疾病,电子信箱:3083324602@qq.com;朱芳(共同第一作者),博士研究生,研究方向为蛋白质稳态与人类疾病,电子信箱:gs.fzhu21@gzu.edu.cn;李聪,硕士研究生(共同第一作者),研究方向为蛋白质稳态与人类疾病,电子信箱:lc13161726107@163.com, correspAuthorsNote=王呈呈(通信作者),讲师,研究方向为肿瘤药理学,电子信箱:ccwang@gzu.edu.cn;胡荣贵(共同通信作者),研究员,研究方向为蛋白质稳态与人类疾病,电子信箱:coryhu@sibcb.ac.cn, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=folbGEZFNkybgKbcxwCuUg==, pdfFileSize=3649775, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=科技部国家重点研发计划项目（2021ZD0203900，2019YFA0802103）；国家自然科学基金委化学科学部项目（81525019）；浙江省重点研发计划项目（2020C03G2012037）；国家自然科学基金项目（31960179）)}, authors=null, keywords=[Keyword(id=1242139635321742242, tenantId=1146029695717560320, journalId=1146031591421210625, 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