Article(id=1242139496284762952, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242139476210819353, articleNumber=null, orderNo=17, doi=10.3981/j.issn.1000-7857.2021.20.011, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1617811200000, receivedDateStr=2021-04-08, revisedDate=1620662400000, revisedDateStr=2021-05-11, acceptedDate=null, acceptedDateStr=null, onlineDate=1636367874507, onlineDateStr=2021-11-08, pubDate=1635350400000, pubDateStr=2021-10-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1636367874507, onlineIssueDateStr=2021-11-08, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774078733746, creator=sys-migrate, updateTime=1774078733746, updator=sys-migrate, issue=Issue{id=1242139476210819353, tenantId=1146029695717560320, journalId=1146031591421210625, year='2021', volume='39', issue='20', pageStart='1', pageEnd='148', issueExtLink='null', onlineDate='null', pubDate='1635350400000', pubDateStr='2021-10-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774078728961, creator='sys-migrate', updateTime=1774078728961, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=116, endPage=125, ext={EN=ArticleExt(id=1242139500839777130, articleId=1242139496284762952, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Micro/nanomotor for drug delivery, columnId=1242116810380743325, journalTitle=Science & Technology Review, columnName=Reviews, runingTitle=null, highlight=null, articleAbstract=Micro/nanomotor drug delivery technology is a new drug delivery mode in vivo based on the self-motion of the drug carrier, which can promote the effective enrichment, retention and penetration of the therapeutic drugs in the lesion site in a nondestructive mode. Its high performance encourages the scientific community to make more effort to accelerate the development of micro/nanomotor in the biomedical field, to find a new way to solve some important traditional biomedical problems at the micro/nano-level, and to establish new principles of the disease treatment and the possible application models. This paper reviews the research progress of micro/nanomotor drug delivery technology, including the drug delivery mode, the drug loading mode, the targeting ability of the micro/nanomotor drug delivery system, the drug delivery movement of micro/nanomotor in the physiological environment, the promotion effect of the autonomous movement of micro/nanomotor in improving the cell uptake and the tissue permeability, and the drug delivery mechanism of micro/nanomotor. Finally, the future development trend of this field is prospected., authors=WAN Mimi, CHEN Tiantian, MAO Chun, SHEN Jian, authorsList=WAN Mimi, CHEN Tiantian, MAO Chun, SHEN Jian, authorCompany=National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=UGYGzNwxBQEk9quadMHmYA==, pdfFileSize=2062162, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242139498440630645, articleId=1242139496284762952, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=微纳米马达在药物递送的应用进展, columnId=1242134377686180284, journalTitle=科技导报, columnName=综述, runingTitle=null, highlight=null, articleAbstract=微纳米马达药物递送技术是一种基于药物载体自身可发生自主运动的新型体内药物递送模式,可以在无损模式下促进治疗药物在病变部位的有效富集、滞留与渗透。简述了微纳米马达药物递送技术的研究进展,阐述了微纳米马达的给药方式、药物负载方式、微纳米马达药物递送体系的靶向能力、微纳米马达在生理环境下的药物递送运动、微纳米马达自主运动在提高细胞摄取和组织渗透性方面的促进作用,以及微纳米马达药物递送体系的具体应用案例等,展望了该领域的未来发展趋势。, authors=万密密, 陈田田, 毛春, 沈健, authorsList=万密密, 陈田田, 毛春, 沈健, authorCompany=南京师范大学化学与材料科学学院, 生物医药功能材料国家地方联合工程研究中心, 南京 210023, correspAuthors=null, authorNote=万密密,副教授,研究方向为生物医用微纳米马达,电子信箱:wanmimi@njnu.edu.cn, correspAuthorsNote=毛春(通信作者),教授,研究方向为生物医用材料,电子信箱:maochun@njnu.edu.cn, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=P2ML988Bx590WItRbauacw==, pdfFileSize=2062162, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, 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科技导报
|综述
2021
, 39
(20) :
116
-125
微纳米马达在药物递送的应用进展
全屏
万密密, 陈田田, 毛春, 沈健
作者信息
南京师范大学化学与材料科学学院, 生物医药功能材料国家地方联合工程研究中心, 南京 210023
通讯作者:
毛春(通信作者),教授,研究方向为生物医用材料,电子信箱:maochun@njnu.edu.cn
作者简介:
万密密,副教授,研究方向为生物医用微纳米马达,电子信箱:wanmimi@njnu.edu.cn
Micro/nanomotor for drug delivery
WAN Mimi, CHEN Tiantian, MAO Chun, SHEN Jian
Affiliations
National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China
出版时间: 2021-10-28
doi: 10.3981/j.issn.1000-7857.2021.20.011
文章导航
微纳米马达药物递送技术是一种基于药物载体自身可发生自主运动的新型体内药物递送模式,可以在无损模式下促进治疗药物在病变部位的有效富集、滞留与渗透。简述了微纳米马达药物递送技术的研究进展,阐述了微纳米马达的给药方式、药物负载方式、微纳米马达药物递送体系的靶向能力、微纳米马达在生理环境下的药物递送运动、微纳米马达自主运动在提高细胞摄取和组织渗透性方面的促进作用,以及微纳米马达药物递送体系的具体应用案例等,展望了该领域的未来发展趋势。
微纳米马达
/
药物递送
/
靶向
/
细胞摄取
/
组织渗透
/
疾病治疗
Micro/nanomotor drug delivery technology is a new drug delivery mode in vivo based on the self-motion of the drug carrier, which can promote the effective enrichment, retention and penetration of the therapeutic drugs in the lesion site in a nondestructive mode. Its high performance encourages the scientific community to make more effort to accelerate the development of micro/nanomotor in the biomedical field, to find a new way to solve some important traditional biomedical problems at the micro/nano-level, and to establish new principles of the disease treatment and the possible application models. This paper reviews the research progress of micro/nanomotor drug delivery technology, including the drug delivery mode, the drug loading mode, the targeting ability of the micro/nanomotor drug delivery system, the drug delivery movement of micro/nanomotor in the physiological environment, the promotion effect of the autonomous movement of micro/nanomotor in improving the cell uptake and the tissue permeability, and the drug delivery mechanism of micro/nanomotor. Finally, the future development trend of this field is prospected.
micro/nanomotor
/
drug delivery
/
targeting
/
cell uptake
/
tissue permeability
/
disease treatment
万密密, 陈田田, 毛春, 沈健.
微纳米马达在药物递送的应用进展.
科技导报,
2021
, 39
(20)
: 116
-125
.
DOI: 10.3981/j.issn.1000-7857.2021.20.011
WAN Mimi, CHEN Tiantian, MAO Chun, SHEN Jian.
Micro/nanomotor for drug delivery[J].
Science & Technology Review ,
2021
, 39
(20)
: 116
-125
.
DOI: 10.3981/j.issn.1000-7857.2021.20.011
2021年第39卷第20期
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文章信息
doi: 10.3981/j.issn.1000-7857.2021.20.011
接收时间:2021-04-08
首发时间:2021-11-08
出版时间:2021-10-28
收稿日期:2021-04-08
修回日期:2021-05-11
通讯作者:
毛春(通信作者),教授,研究方向为生物医用材料,电子信箱:maochun@njnu.edu.cn
https://castjournals.cast.org.cn/joweb/kjdb/CN/10.3981/j.issn.1000-7857.2021.20.011
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2种不同金属材料的力学参数
科 Family 属数 Number of genus 种数 Number of species 占总种数比例 Percentage of total species (%) 属 Genus 种数 Number of species 占总种数比例 Percentage of total species (%) 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
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