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Its high performance encourages the scientific community to make more effort to accelerate the development of micro/nanomotor in the biomedical field, to find a new way to solve some important traditional biomedical problems at the micro/nano-level, and to establish new principles of the disease treatment and the possible application models. This paper reviews the research progress of micro/nanomotor drug delivery technology, including the drug delivery mode, the drug loading mode, the targeting ability of the micro/nanomotor drug delivery system, the drug delivery movement of micro/nanomotor in the physiological environment, the promotion effect of the autonomous movement of micro/nanomotor in improving the cell uptake and the tissue permeability, and the drug delivery mechanism of micro/nanomotor. 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微纳米马达在药物递送的应用进展
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科技导报
| 综述 2021,39(20): 116-125
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科技导报
|综述
2021
, 39
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116
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微纳米马达在药物递送的应用进展
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万密密, 陈田田, 毛春, 沈健
作者信息
南京师范大学化学与材料科学学院, 生物医药功能材料国家地方联合工程研究中心, 南京 210023
通讯作者:
毛春(通信作者),教授,研究方向为生物医用材料,电子信箱:maochun@njnu.edu.cn
作者简介:
万密密,副教授,研究方向为生物医用微纳米马达,电子信箱:wanmimi@njnu.edu.cn
Micro/nanomotor for drug delivery
WAN Mimi, CHEN Tiantian, MAO Chun, SHEN Jian
Affiliations
National and Local Joint Engineering Research Center of Biomedical Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China
Micro/nanomotor drug delivery technology is a new drug delivery mode in vivo based on the self-motion of the drug carrier, which can promote the effective enrichment, retention and penetration of the therapeutic drugs in the lesion site in a nondestructive mode. Its high performance encourages the scientific community to make more effort to accelerate the development of micro/nanomotor in the biomedical field, to find a new way to solve some important traditional biomedical problems at the micro/nano-level, and to establish new principles of the disease treatment and the possible application models. This paper reviews the research progress of micro/nanomotor drug delivery technology, including the drug delivery mode, the drug loading mode, the targeting ability of the micro/nanomotor drug delivery system, the drug delivery movement of micro/nanomotor in the physiological environment, the promotion effect of the autonomous movement of micro/nanomotor in improving the cell uptake and the tissue permeability, and the drug delivery mechanism of micro/nanomotor. Finally, the future development trend of this field is prospected.