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The fasting glucose, the OGTT-AUC, the liver glycogen and the muscle glycogen are measured during the intervention. It is shown that the JOPs could decrease the fasting blood glucose and the OGTT-AUC in the diabetic mice (P<0.05), especially in the 0.4g/kg·bw-dose group. The long-term jackfruit oligopeptides intervention can effectively reduce the blood glucose level and improve the glucose tolerance of diabetic mice., authors=LIU Xinran, KANG Jiawei, WANG Tianxing, HAO Yuntao, ZHU Na, LIU Rui, HU Jiani, MAO Ruixue, LI Yong, authorsList=LIU Xinran, KANG Jiawei, WANG Tianxing, HAO Yuntao, ZHU Na, LIU Rui, HU Jiani, MAO Ruixue, LI Yong, authorCompany=Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=z9bgCme7Is+2r/hboMBf8A==, pdfFileSize=1369000, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), 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科技导报
|研究论文
2021
, 39
(18) :
94
-100
菠萝蜜低聚肽对db/db糖尿病小鼠血糖的影响
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刘欣然, 康家伟, 王天星, 郝云涛, 珠娜, 刘睿, 胡佳妮, 毛瑞雪, 李勇
作者信息
北京大学公共卫生学院营养与食品卫生学系, 北京 100191
通讯作者:
李勇(通信作者),教授,研究方向为肽营养学;营养与疾病,电子信箱:liyongbmu@163.com
作者简介:
刘欣然,博士研究生,研究方向为营养与疾病,电子信箱:liuhappy07@163.com
The hypoglycemic effects of jackfruit oligopeptides in db/db diabetic mice
LIU Xinran, KANG Jiawei, WANG Tianxing, HAO Yuntao, ZHU Na, LIU Rui, HU Jiani, MAO Ruixue, LI Yong
Affiliations
Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China
出版时间: 2021-09-28
doi: 10.3981/j.issn.1000-7857.2021.18.013
文章导航
关于菠萝蜜的研究显示其具有一定的降血糖作用，但尚未有关于菠萝蜜低聚肽（Jack-fruit oligopeptides，JOPs）降血糖的研究。通过菠萝蜜低聚肽干预，研究其对db/db糖尿病模型小鼠血糖的影响作用。将db/db糖尿病小鼠模型，随机分为3个菠萝蜜低聚肽组（0.2 g/kg·bw、0.4 g/kg·bw、0.8 g/kg·bw）以及糖尿病模型对照组、二甲双胍对照组、乳清蛋白对照组；并选用db/m小鼠作为非糖尿病小鼠空白对照。经过为期6周的干预，检测小鼠空腹血糖、糖耐量实验血糖曲线下面积及组织中糖原含量。结果表明，菠萝蜜低聚肽可显著降低db/db糖尿病小鼠空腹血糖水平，显著降低糖耐量实验血糖曲线下面积（P <0.05），其效果以0.4 g/kg·bw剂量组最为显著。菠萝蜜低聚肽干预可有效降低糖尿病小鼠的血糖水平，改善糖耐量，具有辅助降血糖作用。
菠萝蜜低聚肽
/
降血糖
/
糖耐量
/
db/db糖尿病小鼠
To study the hypoglycemic effects of jackfruit oligopeptides in db/db diabetic mice, 48 db/db diabetic mice are randomly divided into six groups (with 8 mice in each group):three jackfruit oligopeptides groups (with 0.2 g/kg·bw, 0.4 g/kg·bw and 0.8 g/kg·bw JOPs, respectively, by intragastric administration), a diabetic model group, a metformin control group (with 0.2 g/kg·bw metformin hydrochloride enteric-coated tablets aqueous solution by intragastric administration) and a whey protein control group (with 0.4 g/kg·bw whey protein aqueous solution by intragastric administration), while 10 db/m mice are used as the blank control for non-diabetic mice. The fasting glucose, the OGTT-AUC, the liver glycogen and the muscle glycogen are measured during the intervention. It is shown that the JOPs could decrease the fasting blood glucose and the OGTT-AUC in the diabetic mice (P<0.05), especially in the 0.4g/kg·bw-dose group. The long-term jackfruit oligopeptides intervention can effectively reduce the blood glucose level and improve the glucose tolerance of diabetic mice.
jackfruit oligopeptides
/
hypoglycemic
/
glucose tolerance
/
db/db diabetic mice
刘欣然, 康家伟, 王天星, 郝云涛, 珠娜, 刘睿, 胡佳妮, 毛瑞雪, 李勇.
菠萝蜜低聚肽对db/db糖尿病小鼠血糖的影响.
科技导报,
2021
, 39
(18)
: 94
-100
.
DOI: 10.3981/j.issn.1000-7857.2021.18.013
LIU Xinran, KANG Jiawei, WANG Tianxing, HAO Yuntao, ZHU Na, LIU Rui, HU Jiani, MAO Ruixue, LI Yong.
The hypoglycemic effects of jackfruit oligopeptides in db/db diabetic mice[J].
Science & Technology Review ,
2021
, 39
(18)
: 94
-100
.
DOI: 10.3981/j.issn.1000-7857.2021.18.013
2021年第39卷第18期
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文章信息
doi: 10.3981/j.issn.1000-7857.2021.18.013
接收时间：2019-05-22
首发时间：2021-10-09
出版时间：2021-09-28
收稿日期：2019-05-22
修回日期：2019-10-05
通讯作者:
李勇(通信作者),教授,研究方向为肽营养学;营养与疾病,电子信箱:liyongbmu@163.com
https://castjournals.cast.org.cn/joweb/kjdb/CN/10.3981/j.issn.1000-7857.2021.18.013
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2种不同金属材料的力学参数
科 属数 种数 占总种数比例 属 种数 占总种数比例 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
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北京市海淀区学院南路86号
010-62199257（仅加盟咨询）
qkjq@cast.org.cn
