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科技导报
| 综述 2021, 39(13): 117-124
熊果酸在神经精神系统疾病中的药理作用及机制研究进展
全屏
石亚静1 , 冷玉芳1,2 , 陈凤1 , 张健民1 , 任以行1 , 刘馨1
作者信息
1. 兰州大学第一临床医学院, 兰州 730000;
2. 兰州大学第一医院麻醉科, 兰州 730000
通讯作者:
冷玉芳(通信作者),教授、主任医师,研究方向为麻醉与器官保护和镇痛机制,电子信箱:lengyf@lzu.edu.cn
Research progress on pharmacological role and mechanism of ursolic acid in nervous-mental system diseases
Affiliations
出版时间: 2021-07-13
doi: 10.3981/j.issn.1000-7857.2021.13.013
文章导航
熊果酸(ursolic acid,UA)是一种五环三萜类化合物,存在于熊果、女贞叶、枇杷叶等植物中。熊果酸不仅具有抗氧化、抗炎、抗肿瘤、抗糖尿病、保肝等药理活性,还具有改善和治疗多种神经精神系统疾病的作用。通过文献分析,归纳总结了熊果酸在神经元损伤、脑血管疾病和精神障碍中的药理作用及其作用机制的研究进展。
Ursolic acid (UA) is a kind of pentacyclic triterpene acid compound found in a variety of plants, such as bearberries, privet leaves, and loquat leaves. In addition to the pharmacological effects of anti-oxidative, anti-inflammatory, anti-cancer, anti-diabetic, and hepatoprotective, UA also has the function of improving and treating many kinds of diseases in nervous-mental system. In this paper, the role of UA in neuronal injury, cerebrovascular diseases as well as mental disorders and its research mechanisms are summarized by literature analysis so as to provide reference for subsequent research and clinical application of UA in nervous-mental system diseases.
ursolic acid
/
nervous-mental system diseases
/
neuroprotection
石亚静, 冷玉芳, 陈凤, 张健民, 任以行, 刘馨.
熊果酸在神经精神系统疾病中的药理作用及机制研究进展.
科技导报,
2021
, 39
(13)
: 117
-124
.
DOI: 10.3981/j.issn.1000-7857.2021.13.013
SHI Yajing, LENG Yufang, CHEN Feng, ZHANG Jianmin, REN Yixing, LIU Xin.
Research progress on pharmacological role and mechanism of ursolic acid in nervous-mental system diseases[J].
Science & Technology Review ,
2021
, 39
(13)
: 117
-124
.
DOI: 10.3981/j.issn.1000-7857.2021.13.013
2021年第39卷第13期
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文章信息
doi: 10.3981/j.issn.1000-7857.2021.13.013
接收时间:2020-03-19
首发时间:2021-08-11
出版时间:2021-07-13
收稿日期:2020-03-19
修回日期:2021-05-12
通讯作者:
冷玉芳(通信作者),教授、主任医师,研究方向为麻醉与器官保护和镇痛机制,电子信箱:lengyf@lzu.edu.cn
https://castjournals.cast.org.cn/joweb/kjdb/CN/10.3981/j.issn.1000-7857.2021.13.013
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2种不同金属材料的力学参数
科 Family 属数 Number of genus 种数 Number of species 占总种数比例 Percentage of total species (%) 属 Genus 种数 Number of species 占总种数比例 Percentage of total species (%) 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
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