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科技导报
| 专题:肿瘤标志物 2021, 39(7): 48-62
纳米硒的功能设计及其在肿瘤精准治疗中的应用进展
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张泽杭1 , 刘婷1 , 李海伟2 , 桑诚诚2 , 陈义康2 , 陈填烽1
作者信息
1. 暨南大学化学与材料学院, 广州 510632;
2. 广东暨创硒源纳米研究院有限公司, 广州 510535
通讯作者:
陈填烽(通信作者),教授,研究方向为肿瘤靶向化学创新药物与诊疗应用,电子信箱:20678518@qq.com
Functional design of selenium nanomedicine and its application progress in tumor precision treatment
Affiliations
出版时间: 2021-04-13
doi: 10.3981/j.issn.1000-7857.2021.07.005
文章导航
纳米硒作为一种新型单质硒,与有机硒和无机硒相比具有更高的生物利用度,更强的生物活性和更低的毒性,并且具有抗氧化和抗肿瘤的作用。概述了纳米硒在生物医药中的应用,包括纳米硒用于化疗、放疗、放化疗以及其他临床药物的增敏,纳米硒的功能化和靶向修饰增强抗肿瘤效果,含硒纳米材料在抗肿瘤中的应用,纳米硒的毒理学,介绍了纳米硒制剂产业化发展情况。
Nanoselenium, as a new type of elemental selenium, has higher bioavailability, stronger biological activity and lower toxicity than organic selenium and inorganic selenium, and simultaneously has anti-oxidant and anti-tumor effects. This article mainly summarizes the application progress of selenium nanoparticles (SeNPs) in biomedicine, such as chemotherapy, radiotherapy, radio-chemotherapy and other clinical drugs to enhance the sensitization by SeNPs; the functionalization and targeted modification of SeNPs to enhance the anti-tumor effect; Se-nanomaterials in anti-tumor application; the toxicology of SeNPs; and the description of the industrialization research of SeNPs production. The review provides a guidance and support for the future nanoselenium production, study and research integration system.
selenium nanoparticles
/
tumour
/
accurate treatment
张泽杭, 刘婷, 李海伟, 桑诚诚, 陈义康, 陈填烽.
纳米硒的功能设计及其在肿瘤精准治疗中的应用进展.
科技导报,
2021
, 39
(7)
: 48
-62
.
DOI: 10.3981/j.issn.1000-7857.2021.07.005
ZHANG Zehang, LIU Ting, LI Haiwei, SANG Chengcheng, CHEN Yikang, CHEN Tianfeng.
Functional design of selenium nanomedicine and its application progress in tumor precision treatment[J].
Science & Technology Review ,
2021
, 39
(7)
: 48
-62
.
DOI: 10.3981/j.issn.1000-7857.2021.07.005
2021年第39卷第7期
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文章信息
doi: 10.3981/j.issn.1000-7857.2021.07.005
接收时间:2020-09-24
首发时间:2021-05-13
出版时间:2021-04-13
收稿日期:2020-09-24
修回日期:2021-01-31
通讯作者:
陈填烽(通信作者),教授,研究方向为肿瘤靶向化学创新药物与诊疗应用,电子信箱:20678518@qq.com
https://castjournals.cast.org.cn/joweb/kjdb/CN/10.3981/j.issn.1000-7857.2021.07.005
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2种不同金属材料的力学参数
科 Family 属数 Number of genus 种数 Number of species 占总种数比例 Percentage of total species (%) 属 Genus 种数 Number of species 占总种数比例 Percentage of total species (%) 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
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