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The American oncologist William G. Kaelin Jr., the British medical scientist Sir Peter J. Ratcliffe and the American medical scientist Gregg L. Semenza won the 2019 Nobel Prize in Physiology or Medicine for discovering how cells sense and adapt to the oxygen availability where the HIF plays an important role. This paper reviews the research progress of the HIF in the treatment of renal anemia, tumor, cardiovascular disease, as well as its significance to human health., authors=LI Han, LU Xiangxue, authorsList=LI Han, LU Xiangxue, authorCompany=Department of Blood Purification, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=p8EThhcfapljw72i2OEE0A==, pdfFileSize=1288050, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242137952705393576, articleId=1242137949932958618, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=低氧诱导因子在疾病治疗中的新进展——2019年诺贝尔生理学或医学奖成果简析, columnId=1242137945759621278, journalTitle=科技导报, columnName=专题：2019年诺贝尔科学奖成果简介, runingTitle=null, highlight=null, articleAbstract=低氧诱导因子是一种异二聚体结构的DNA结合转录因子，它可以与特定的核辅因子结合，激活多种基因，在缺氧条件下优化氧的利用。美国癌症学家William G.Kaelin Jr、英国医学家Sir Peter J.Ratcliffe和美国医学家Gregg L.Semenza因发现了细胞如何感知和适应氧可用性，获得了2019年的诺贝尔生理学或医学奖，其中HIF发挥了重要的作用。介绍了HIF在肾性贫血、肿瘤、心血管疾病等治疗中的研究进展，探讨了其对人类健康的意义。, authors=李寒, 路香雪, authorsList=李寒, 路香雪, authorCompany=首都医科大学附属北京朝阳医院血液净化科, 北京 100020, correspAuthors=null, authorNote=李寒,主任医师、教授,研究方向为肾脏病与血液净化,电子信箱:hanli@ccmu.edu.cn;路香雪(共同第一作者),博士研究生,研究方向为肾脏病与血液净化,电子信箱:xiangxuelu@ccmu.edu.cn, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=2RrfRY1O3dR0tUt91vbyZg==, pdfFileSize=1288050, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, 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科技导报
|专题：2019年诺贝尔科学奖成果简介
2019
, 37
(24) :
51
-56
低氧诱导因子在疾病治疗中的新进展——2019年诺贝尔生理学或医学奖成果简析
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李寒, 路香雪
作者信息
首都医科大学附属北京朝阳医院血液净化科, 北京 100020
作者简介:
李寒,主任医师、教授,研究方向为肾脏病与血液净化,电子信箱:hanli@ccmu.edu.cn;路香雪(共同第一作者),博士研究生,研究方向为肾脏病与血液净化,电子信箱:xiangxuelu@ccmu.edu.cn
New progress of hypoxia inducible factor in the treatment of diseases
LI Han, LU Xiangxue
Affiliations
Department of Blood Purification, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China
出版时间: 2019-12-28
doi: 10.3981/j.issn.1000-7857.2019.24.007
文章导航
低氧诱导因子是一种异二聚体结构的DNA结合转录因子，它可以与特定的核辅因子结合，激活多种基因，在缺氧条件下优化氧的利用。美国癌症学家William G.Kaelin Jr、英国医学家Sir Peter J.Ratcliffe和美国医学家Gregg L.Semenza因发现了细胞如何感知和适应氧可用性，获得了2019年的诺贝尔生理学或医学奖，其中HIF发挥了重要的作用。介绍了HIF在肾性贫血、肿瘤、心血管疾病等治疗中的研究进展，探讨了其对人类健康的意义。
低氧诱导因子
/
2019年诺贝尔生理学或医学奖
/
肾性贫血
/
肿瘤
/
心血管疾病
The hypoxia inducible factor (HIF) is a heterodimer DNA-binding transcription factor that can bind with specific nuclear cofactors and activate a variety of genes to optimize the oxygen utilization under hypoxia conditions. The American oncologist William G. Kaelin Jr., the British medical scientist Sir Peter J. Ratcliffe and the American medical scientist Gregg L. Semenza won the 2019 Nobel Prize in Physiology or Medicine for discovering how cells sense and adapt to the oxygen availability where the HIF plays an important role. This paper reviews the research progress of the HIF in the treatment of renal anemia, tumor, cardiovascular disease, as well as its significance to human health.
hypoxia-inducible factor
/
Nobel Prize in Physiology or Medicine 2019
/
renal anemia
/
tumor
/
cardiovascular disease
李寒, 路香雪.
低氧诱导因子在疾病治疗中的新进展——2019年诺贝尔生理学或医学奖成果简析.
科技导报,
2019
, 37
(24)
: 51
-56
.
DOI: 10.3981/j.issn.1000-7857.2019.24.007
LI Han, LU Xiangxue.
New progress of hypoxia inducible factor in the treatment of diseases[J].
Science & Technology Review ,
2019
, 37
(24)
: 51
-56
.
DOI: 10.3981/j.issn.1000-7857.2019.24.007
2019年第37卷第24期
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文章信息
doi: 10.3981/j.issn.1000-7857.2019.24.007
接收时间：2019-11-04
首发时间：2020-01-02
出版时间：2019-12-28
收稿日期：2019-11-04
修回日期：2019-12-16
https://castjournals.cast.org.cn/joweb/kjdb/CN/10.3981/j.issn.1000-7857.2019.24.007
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2种不同金属材料的力学参数
科 属数 种数 占总种数比例 属 种数 占总种数比例 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
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