Article(id=1242137647221650172, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242137639663514351, articleNumber=null, orderNo=9, doi=10.3981/j.issn.1000-7857.2019.14.007, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1542643200000, receivedDateStr=2018-11-20, revisedDate=1552579200000, revisedDateStr=2019-03-15, acceptedDate=null, acceptedDateStr=null, onlineDate=1563959267277, onlineDateStr=2019-07-24, pubDate=1564243200000, pubDateStr=2019-07-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1563959267277, onlineIssueDateStr=2019-07-24, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774078292894, creator=sys-migrate, updateTime=1774078292894, updator=sys-migrate, issue=Issue{id=1242137639663514351, tenantId=1146029695717560320, journalId=1146031591421210625, year='2019', volume='37', issue='14', pageStart='1', pageEnd='104', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=null, issueType=-1, specialIssue=null, createTime=1774078291093, creator=sys-migrate, updateTime=1774078291093, updator=sys-migrate, preIssue=null, nextIssue=null, ext=null, issueFiles=null}, startPage=51, endPage=58, ext={EN=ArticleExt(id=1242137653311779614, articleId=1242137647221650172, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Development and change of research and market in the field of genetically modified mouse in China in recent 20 years, columnId=1242116810380743325, journalTitle=Science & Technology Review, columnName=Reviews, runingTitle=null, highlight=null, articleAbstract=Experimental zoology in China began to develop in the early 1980s. With the rapid development of China's reform and opening up, China's experimental animal science and industry have entered the regular development stage. Genetically modified mice, as an important part of experimental animals, have developed rapidly in China in the past two decades, and have been successively applied in life science and basic medical research, antibody drug evaluation, antibody drug research development and other transformation applications. This review is to expound the development situation of genetically modified mice through the classified statistics and research methods on the six aspects including national investment, institution construction, market development, academic exchange, work focus and achievement accumulation. Finally, this review summarizes the standard establishment process and research development of genetically modified mice in China in the past two decades., correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=4BeqRLLr8/xV5Hf4djLdMQ==, pdfFileSize=1229011, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=1. College of Basic Medicine, Harbin Medical University, Harbin 150081, China;
2. Shanghai Jiu Hu He Biology Science and Technology Co., Ltd., Shanghai 201203, China;
3. Key Laboratory of Genetically Modifed animals of Heilongjiang Province, Harbin 150081, China;
4. Basic Medical Institute of Heilongjiang Medical Science Academy, Harbin 150081, China;
5. Translational Medicine Center of Northern China, Harbin 150081, China, fund=null, authors=MA Ning¹, LI Zhenghua¹, SHI Ji², QIAO Yu¹, WANG Dayong¹, GAO Xu^1,3,4,5, authorsList=MA Ning, LI Zhenghua, SHI Ji, QIAO Yu, WANG Dayong, GAO Xu), CN=ArticleExt(id=1242137650912637710, articleId=1242137647221650172, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=中国遗传改变小鼠研发与市场在近20年的发展与变化, columnId=1242134377686180284, journalTitle=科技导报, columnName=综述, runingTitle=null, highlight=null, articleAbstract=遗传改变小鼠是基因组经过“修饰”或“改造”的实验用小鼠，作为实验动物的重要组成在中国近20年里得到了飞速发展，被先后应用于生命科学与医学的基础研究、抗体药物评价与抗体药物研发等转化应用项目中。介绍了近20年中国遗传改变小鼠领域的国家投入、机构建设、市场发展、学术交流、工作重点及成果积累等方面的发展与变化。, correspAuthors=null, authorNote=马宁,副教授,研究方向为遗传改变小鼠研发与应用,电子信箱:maning@hrbmu.edu.cn, correspAuthorsNote=高旭(通信作者),教授,研究方向为遗传改变小鼠研发与应用,电子信箱:gaoxu@hrbmu.edu.cn, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=ptSDRGZNKZJhAKUtF6GU3g==, pdfFileSize=1229011, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=1. 哈尔滨医科大学基础医学院, 哈尔滨 150081;
2. 上海九葫禾生物科技有限公司, 上海 201203;
3. 黑龙江省遗传改变模式动物重点实验室, 哈尔滨 150081;
4. 黑龙江省基础医学研究所, 哈尔滨 150081;
5. 北方转化医学研究与合作中心, 哈尔滨 150081, fund=哈尔滨市科技局创新人才项目（2016RAYBJ006）；黑龙江省博士后科研启动基金项目（LBH-Q15108）；黑龙江省自然科学基金项目（H2018006）；黑龙江省高等教育教学改革研究项目（SJGY20170419）；黑龙江省重大研发项目（GA16C105）；国家自然科学基金项目（81570534，81773165）, authors=马宁¹, 李正花¹, 史季², 乔瑜¹, 王大勇¹, 高旭^1,3,4,5, authorsList=马宁, 李正花, 史季, 乔瑜, 王大勇, 高旭)}, authors=null, keywords=[Keyword(id=1242137650463847172, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242137647221650172, language=CN, orderNo=1, keyword=遗传改变小鼠), Keyword(id=1242137650556121862, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242137647221650172, language=CN, orderNo=1, keyword=遗传(基因)工程小鼠), Keyword(id=1242137650627425032, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242137647221650172, language=CN, orderNo=1, keyword=遗传(基因)修饰小鼠), Keyword(id=1242137650702922506, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242137647221650172, language=CN, orderNo=1, keyword=全人源化抗体), 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