Article(id=1242137592657949237, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242137589919068720, articleNumber=null, orderNo=3, doi=10.3981/j.issn.1000-7857.2019.11.001, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1548604800000, receivedDateStr=2019-01-28, revisedDate=1549296000000, revisedDateStr=2019-02-05, acceptedDate=null, acceptedDateStr=null, onlineDate=1561025569627, onlineDateStr=2019-06-20, pubDate=1560355200000, pubDateStr=2019-06-13, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1561025569627, onlineIssueDateStr=2019-06-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774078279885, creator=sys-migrate, updateTime=1774078279886, updator=sys-migrate, issue=Issue{id=1242137589919068720, tenantId=1146029695717560320, journalId=1146031591421210625, year='2019', volume='37', issue='11', pageStart='1', pageEnd='108', issueExtLink='null', onlineDate='null', pubDate='1560355200000', pubDateStr='2019-06-13', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=null, issueType=-1, specialIssue=null, createTime=1774078279233, creator='sys-migrate', updateTime=1774078279233, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=6, endPage=8, ext={EN=ArticleExt(id=1242137596030165695, articleId=1242137592657949237, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Why did FDA grant Zanubrutinib breakthrough designation for mantle cell lymphoma?, columnId=1242136927416168874, journalTitle=Science & Technology Review, columnName=Scientific Comments, runingTitle=null, highlight=null, articleAbstract=The U.S. Food and Drug Administration (FDA) has granted the investigational BTK inhibitor Zanubrutinib (BGB-3111) a breakthrough therapy designation for the treatment of adult patients with mantle cell lymphoma (MCL) who have previously received at least 1 prior therapy, on Jan. 15th 2019. This paper introduced the definition of the breakthrough therapy designation, the breakthrough achievements of Zanubrutinib, the significance of this event to Chinese pharmaceutical R&D enterprises., authors=ZHANG Hongtao, authorsList=ZHANG Hongtao, authorCompany=Pathology and Laboratory Medicine, Perelman School of Medicine, Philadelphia 19104, USA, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=TbHw0mDjHfuOO0hYz5E0Jg==, pdfFileSize=843477, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242137595245834809, articleId=1242137592657949237, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=中国第一个获得美国FDA“突破性疗法”认证的抗癌新药，到底好在哪?, columnId=1150494642043760854, journalTitle=科技导报, columnName=科技评论, runingTitle=null, highlight=null, articleAbstract=2019年1月15日，美国食品和药物管理局（FDA）授予了一款在研的布鲁顿氏酪氨酸激酶（BTK）抑制剂泽布替尼（Zanubrutinib）突破性疗法认证，用于治疗先前接受至少一次疗法的成年套细胞淋巴瘤（MCL）患者，这也成为首个在FDA获得突破性疗法认定的中国自主研发抗癌新药。介绍了突破性疗法认证的定义，讲述了新型布鲁顿氏酪氨酸激酶抑制剂泽布替尼的特点，阐述了其对中国医药研发企业的意义。, authors=张洪涛, authorsList=张洪涛, authorCompany=宾夕法尼亚大学医学院病理及实验医学系, 美国费城 19104, correspAuthors=null, authorNote=张洪涛,副教授,研究方向为癌症靶向治疗、免疫治疗,电子信箱:zhanghon@mail.upenn.edu, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=PftQ4MKyj2qhd05WRDoxlQ==, pdfFileSize=843477, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null)}, authors=null, 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