Article(id=1242137311614415398, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242137295021748728, articleNumber=null, orderNo=10, doi=10.3981/j.issn.1000-7857.2019.01.008, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1546012800000, receivedDateStr=2018-12-29, revisedDate=1547049600000, revisedDateStr=2019-01-10, acceptedDate=null, acceptedDateStr=null, onlineDate=1548744550407, onlineDateStr=2019-01-29, pubDate=1547308800000, pubDateStr=2019-01-13, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1548744550407, onlineIssueDateStr=2019-01-29, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774078212880, creator=sys-migrate, updateTime=1774078212880, updator=sys-migrate, issue=Issue{id=1242137295021748728, tenantId=1146029695717560320, journalId=1146031591421210625, year='2019', volume='37', issue='1', pageStart='1', pageEnd='228', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774078208924, creator=sys-migrate, updateTime=1774078208924, updator=sys-migrate, preIssue=null, nextIssue=null, ext=null, issueFiles=null}, startPage=87, endPage=90, ext={EN=ArticleExt(id=1242137315074712173, articleId=1242137311614415398, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Hotspots of cancer immunology in 2018, columnId=1242137301782962719, journalTitle=Science & Technology Review, columnName=Exclusive: Science and Technology Review in 2018, runingTitle=null, highlight=null, articleAbstract=Tumor immunotherapy has become a first line option for cancer treatment, a hot field in cancer research and a weapon to overcome cancer in the future. A series of tumor immunotherapeutic drugs have been approved and used in clinic. Also the Nobel Prize in Physiology or Medicine in 2018 was awarded to two immunologists who had made outstanding contributions to tumor immunotherapy, revealing the coming of immunotherapy age. This article outlines the hotspots and advances of tumor immunology and immunotherapy in 2018, including the discovery of new immune checkpoints, in-depth understanding of T cell exhaustion, discovery of new tumor immunosuppressive cell subsets, and exploration of new strategies for tumor immunotherapy. These studies will further promote the development of tumor immunotherapy and bring more effective treatments to cancer patients., correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=2mkzZ34VbyvTVE2w50D7vQ==, pdfFileSize=707533, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100730, China, fund=null, authors=HUANG Bo, authorsList=HUANG Bo), CN=ArticleExt(id=1242137313698980447, articleId=1242137311614415398, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=2018年肿瘤免疫研究热点回眸, columnId=1242137300516282901, journalTitle=科技导报, columnName=专题：2018年科技回眸, runingTitle=null, highlight=null, articleAbstract=肿瘤免疫疗法已成为肿瘤治疗的重要手段，是肿瘤研究领域的焦点和热点。肿瘤免疫治疗相关药物相继问世，而2018年度诺贝尔生理学或医学奖授予两位在肿瘤免疫治疗中有突出贡献的免疫学家，更是确立了肿瘤免疫治疗时代的到来。本文概述了2018年肿瘤免疫治疗研究的热点及进展，包括新的肿瘤免疫检查点的发现、T细胞耗竭的深入探究、新的肿瘤免疫抑制细胞亚群的发现以及肿瘤免疫治疗新策略的探索。, correspAuthors=null, authorNote=黄波,教授,研究方向为肿瘤免疫,电子信箱:tjhuangbo@hotmail.com, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=JeX3S5MQqZgrRyfZm55YPw==, pdfFileSize=707533, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=中国医学科学院基础医学研究所, 北京 100730, fund=国家自然科学基金基础科学中心项目（81788101）；中国医学科学院医学与健康创新工程项目（2016-I2M-1-007）, authors=黄波, authorsList=黄波)}, authors=null, keywords=[Keyword(id=1242137313258578522, tenantId=1146029695717560320, journalId=1146031591421210625, 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