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2. Bio-X Institutes, Shanghai Jiao Tong University, Shanghai 200030, China, fund=null, authors=JIANG Qiao¹, WEI Yu^1,2, LI Can², SONG Linlin¹, DING Baoquan¹, ZHAO Yuliang¹, authorsList=JIANG Qiao, WEI Yu, LI Can, SONG Linlin, DING Baoquan, ZHAO Yuliang), CN=ArticleExt(id=1242137218798657904, articleId=1242137215690678626, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=DNA纳米机器药物递送研究进展, columnId=1242137213048271044, journalTitle=科技导报, columnName=专题：纳米生物医学, runingTitle=null, highlight=null, articleAbstract=天然分子机器是细胞正常功能（包括DNA复制、细胞内物质运输、离子平衡和细胞运动等）的重要执行者。受天然分子机器的启发，人工分子机器的概念被提出并逐步实践。DNA分子独特的理化性质使得其可作为自组装基元用于构建分子机器类纳米结构。DNA纳米结构具有形状可设计性、精确的可寻址性、结构动态响应性及良好的生物相容性，可以作为一种良好的药物递送载体材料。通过可寻址的负载特定功能元件从而构建DNA纳米载体和治疗型DNA纳米机器，可以靶向性地将药物传递到病变组织和细胞，响应性地释放药物，提高药物的细胞摄取率并降低其毒副作用，有望成为优秀的药物递送系统。基于DNA纳米结构的药物载体已经被用于递送小分子药物、寡核苷酸类药物和蛋白药物。以每类药物分子中的典型药物为例，介绍了DNA纳米载体和DNA纳米机器药物递送系统的研究进展，并讨论了其所面临的挑战及可能的发展趋势。, correspAuthors=null, authorNote=蒋乔,副研究员,研究方向为DNA纳米结构的生物医学应用,电子信箱:jiangq@nanoctr.cn;韦雨,硕士研究生(共同第一作者),研究方向为DNA纳米载药体系设计与构建,电子信箱:weiy@nanoctr.cn, correspAuthorsNote=丁宝全(通信作者),研究员,研究方向为基于DNA的生物大分子功能化自组装及应用,电子信箱:dingbq@nanoctr.cn;赵宇亮(通信作者),研究员,研究方向为纳米毒理学、纳米药物及放射化学,电子信箱:zhaoyl@nanoctr.cn, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=noAqNunP9cwvGeO/Vcy8KA==, pdfFileSize=2071670, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=1. 国家纳米科学中心, 北京 100190;
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