Article(id=1242137215271252172, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242137208371622071, articleNumber=null, orderNo=5, doi=10.3981/j.issn.1000-7857.2018.22.003, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1526227200000, receivedDateStr=2018-05-14, revisedDate=1537200000000, revisedDateStr=2018-09-18, acceptedDate=null, acceptedDateStr=null, onlineDate=1544768629457, onlineDateStr=2018-12-14, pubDate=1543334400000, pubDateStr=2018-11-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1544768629457, onlineIssueDateStr=2018-12-14, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774078189908, creator=sys-migrate, updateTime=1774078189908, updator=sys-migrate, issue=Issue{id=1242137208371622071, tenantId=1146029695717560320, journalId=1146031591421210625, year='2018', volume='36', issue='22', pageStart='1', pageEnd='160', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774078188263, creator=sys-migrate, updateTime=1774078188263, updator=sys-migrate, preIssue=null, nextIssue=null, ext=null, issueFiles=null}, startPage=27, endPage=53, ext={EN=ArticleExt(id=1242137219520082150, articleId=1242137215271252172, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Application of aggregation-induced emission materials in bioimaging, disease diagnosis and therapy, columnId=1242137214231064779, journalTitle=Science & Technology Review, columnName=Exclusive: Nanobiomedicine, runingTitle=null, highlight=null, articleAbstract=The study of the underlying mechanism of aggregation-induced emission (AIE), design and synthesis of novel AIE molecules and their application in various fields of daily life are the current hot research topics. According to AIE mechanism of restriction of intramolecular motions, a variety of AIE probes with "turn-on" sensing feature have been designed to provide much lower background and higher signal reliability, which are particularly attractive and suitable for use in biology. Since the unbound AIE probes have a low background, the use of the AIE bioprobes also has the advantage of not requiring washing steps, which greatly saves the operation time and eliminates the loss of the samples. The formed AIE aggregates have excellent photostability and resistance to photobleaching during detection, allowing long-term tracking and monitoring. AIE bioprobes have been designed and applied to fields of biomolecular detection, cellular structure imaging, bacterial imaging, cell tracking, angiography, in vivo tumor imaging and therapy, etc. With the recently achieved numerous results, herein, we first briefly introduce the origin of AIE, then we discuss the working mechanism of AIE and the construction of AIE probes. Finally we summarize the recent works of AIE in different aspects of bioimaging, disease diagnosis and treatment., correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=DYhEY/EkGrWoF0W15m4lRw==, pdfFileSize=4965380, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=1. HKUST-Shenzhen Research Institute, Shenzhen 518057, China;
2. Department of Chemistry, Hong Kong University of Science and Technology;Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction;HKUST Jockey Club Institute for Advanced Study, Clear Water Bay, Kowloon, Hong Kong, China;
3. State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, China, fund=null, authors=JIANG Meijuan^1,2, KWOK Tsz Kin^1,2, TANG Benzhong^1,2,3, authorsList=JIANG Meijuan, KWOK Tsz Kin, TANG Benzhong), CN=ArticleExt(id=1242137217708142800, articleId=1242137215271252172, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=聚集诱导发光材料在生物成像、疾病诊断及治疗的应用, columnId=1242137213048271044, journalTitle=科技导报, columnName=专题：纳米生物医学, runingTitle=null, highlight=null, articleAbstract=聚集诱导发光（AIE）从2001年提出到现在，经历了迅猛的发展。研究AIE的发光机理、设计合成新型的AIE分子，应用到人类生活的各个领域中是当前的研究热点。在生物医学应用上，AIE分子相比于传统的结构平面刚性的荧光材料具有优势。根据AIE的发光机理——分子内运动受限，研究者设计出多种点亮型的AIE探针，它们可以在生物检测中提供更低的背景和更可靠的信号。同时，由于未结合检测物的AIE探针具有低背景，使用AIE探针的应用还具有无需洗涤步骤的优点，大大节省了操作时间及减少检测样品的损失。检测形成的AIE聚集体具有优异的光稳定性和抗光漂白性，可以实现长时间的追踪和监测。目前，AIE生物探针在生物分子检测、细胞器成像、细菌成像、细胞追踪、血管成像、体内肿瘤成像与治疗等方面已经取得了众多的成果。本文介绍了AIE的提出、AIE的工作机理，AIE生物探针的构建，总结了AIE探针在生物成像、疾病诊断及治疗等不同方面的应用。, correspAuthors=null, authorNote=江美娟,博士研究生,研究方向为聚集诱导发光材料的合成、机理研究和生物成像应用,电子信箱:mjiangae@connect.ust.hk, correspAuthorsNote=唐本忠(通信作者),教授,研究方向为三键聚合方法和聚集诱导发光材料合成、机理和应用,电子信箱:tangbenz@ust.hk, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=0wYn4kthZ2hlLScseyXxZw==, pdfFileSize=4965380, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=1. 香港科技大学深圳研究院, 深圳 518057;
2. 香港科技大学化学系, 国家人体组织功能重建工程技术研究中心(香港分中心), 香港赛马会高等研究院, 香港九龙清水湾;
3. 华南理工大学, 发光材料与器件国家重点实验室, 广州 510640, fund=国家自然科学基金项目（201788102）；香港特别行政区政府创新科技署项目（ITC-CNERC14SC01）；香港研究资助局项目（16301614，16305015，N_HKUST604/14，A-HKUST605/16）；广东省引进创新科研团队项目（201101C0105067115）；深圳市科技计划项目（JCYJ20160229205601482，JCYJ20170307173739739，JCYJ20170818113840164，JCYJ20170818113851132）, authors=江美娟^1,2, 郭子健^1,2, 唐本忠^1,2,3, authorsList=江美娟, 郭子健, 唐本忠)}, authors=null, keywords=[Keyword(id=1242137217225793892, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242137215271252172, language=CN, orderNo=1, keyword=聚集诱导发光), Keyword(id=1242137217292902757, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242137215271252172, language=CN, orderNo=1, keyword=荧光探针), Keyword(id=1242137217364205926, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242137215271252172, language=CN, orderNo=1, keyword=生物成像), Keyword(id=1242137217464869223, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242137215271252172, 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