Article(id=1242136766052904967, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242136747048514511, articleNumber=null, orderNo=11, doi=10.3981/j.issn.1000-7857.2018.06.009, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1502985600000, receivedDateStr=2017-08-18, revisedDate=1504454400000, revisedDateStr=2017-09-04, acceptedDate=null, acceptedDateStr=null, onlineDate=1522827166687, onlineDateStr=2018-04-04, pubDate=1522166400000, pubDateStr=2018-03-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1522827166687, onlineIssueDateStr=2018-04-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774078082808, creator=sys-migrate, updateTime=1774078082808, updator=sys-migrate, issue=Issue{id=1242136747048514511, tenantId=1146029695717560320, journalId=1146031591421210625, year='2018', volume='36', issue='6', pageStart='1', pageEnd='120', issueExtLink='null', onlineDate='null', pubDate='1522166400000', pubDateStr='2018-03-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774078078274, creator='sys-migrate', updateTime=1774078078274, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=77, endPage=82, ext={EN=ArticleExt(id=1242136769186045989, articleId=1242136766052904967, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Development of implantable silicon neural microelectrodes, columnId=1242116810380743325, journalTitle=Science & Technology Review, columnName=Reviews, runingTitle=null, highlight=null, articleAbstract=The mechanisms by which the brain produces, transmits, and processes information are related with the neuroscience and the neural engineering, involving the electrical activity of brain neurons. As a kind of implantable sensor, the micro neural probe is one of the highest resolution tools used to record the neural activity. It can record electrical potentials of single neurons without damaging the nervous system. In order to record tens of billions of neurons in the brain, the more electrodes that can be simultaneously implanted, the more details of information processing by brain can be obtained. Thus, smaller volume and higher integration are required. As a kind of mature micro machining materials, silicon enjoys excellent mechanical properties and good biological compatibility. The neural microelectrode array fabricated from silicon has the advantages of small size, high integration and good electrical consistency. In this paper, the structure characteristics, the preparation methods and the performance of several mainstream implanted silicon based neural microelectrodes are reviewed. Through the continuous optimization of the structure, and the improvement of the modification methods and methods, the number of electrodes on one probe can be increased greatly, and the biocompatibility of the silicon based neural electrode be improved dramatically. In the area of high-throughput neural recording, the silicon based electrode fabricated with standard CMOS process and integrated with amplifier, as well as the analogue to digital circuit is a hopeful method to realize large-scale neural recording in-vivo ,to replace the point to point connection between the electrode array in body and the recording equipment outside body with several digital lines., authors=PEI Weihua1,2,3 , authorsList=PEI Weihua, authorCompany=1. State Key Laboratory of Integrated Optoelectronics;Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China;1,2,3 , authorsList=裴为华, authorCompany=1. 中国科学院半导体研究所, 集成光电子学国家重点联合实验室, 北京 100083;
科技导报
|综述
2018
, 36
(6) :
77
-82
植入式硅神经微电极的发展
全屏
裴为华1,2,3
作者信息
1. 中国科学院半导体研究所, 集成光电子学国家重点联合实验室, 北京 100083;
作者简介:
裴为华,研究员,研究方向为神经接口技术与器件,电子信箱:peiwh@semi.ac.cn
Development of implantable silicon neural microelectrodes
PEI Weihua1,2,3
Affiliations
1. State Key Laboratory of Integrated Optoelectronics;Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China;
出版时间: 2018-03-28
doi: 10.3981/j.issn.1000-7857.2018.06.009
文章导航
神经科学和神经工程研究需要研究大脑神经元的电活动情况，以了解大脑产生、传输和处理信息的机制。植入式神经微电极作为一种传感器件，是时间分辨率最高的神经电活动传感手段之一。介绍了国内外几种主要的植入式硅基神经微电极的结构特点、制备方法和性能特点。分析表明，未来通过不断结构优化和改性修饰，特别是在高通量的神经记录方面，通过与同样基于硅材料的电路的集成，硅神经微电极能够进一步提高生物相容性，解决大规模的电极通道体内外传输与连接问题，实现对神经元的在体大规模长时间记录。
神经微电极
/
微丝电极阵列
/
体硅微电极
/
薄膜硅微电极
The mechanisms by which the brain produces, transmits, and processes information are related with the neuroscience and the neural engineering, involving the electrical activity of brain neurons. As a kind of implantable sensor, the micro neural probe is one of the highest resolution tools used to record the neural activity. It can record electrical potentials of single neurons without damaging the nervous system. In order to record tens of billions of neurons in the brain, the more electrodes that can be simultaneously implanted, the more details of information processing by brain can be obtained. Thus, smaller volume and higher integration are required. As a kind of mature micro machining materials, silicon enjoys excellent mechanical properties and good biological compatibility. The neural microelectrode array fabricated from silicon has the advantages of small size, high integration and good electrical consistency. In this paper, the structure characteristics, the preparation methods and the performance of several mainstream implanted silicon based neural microelectrodes are reviewed. Through the continuous optimization of the structure, and the improvement of the modification methods and methods, the number of electrodes on one probe can be increased greatly, and the biocompatibility of the silicon based neural electrode be improved dramatically. In the area of high-throughput neural recording, the silicon based electrode fabricated with standard CMOS process and integrated with amplifier, as well as the analogue to digital circuit is a hopeful method to realize large-scale neural recording in-vivo ,to replace the point to point connection between the electrode array in body and the recording equipment outside body with several digital lines.
neural microelectrode
/
micro-wire electrode array
/
bulk silicon electrode
/
thin-film silicon electrode
裴为华.
植入式硅神经微电极的发展.
科技导报,
2018
, 36
(6)
: 77
-82
.
DOI: 10.3981/j.issn.1000-7857.2018.06.009
PEI Weihua.
Development of implantable silicon neural microelectrodes[J].
Science & Technology Review ,
2018
, 36
(6)
: 77
-82
.
DOI: 10.3981/j.issn.1000-7857.2018.06.009
2018年第36卷第6期
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文章信息
doi: 10.3981/j.issn.1000-7857.2018.06.009
接收时间：2017-08-18
首发时间：2018-04-04
出版时间：2018-03-28
收稿日期：2017-08-18
修回日期：2017-09-04
https://castjournals.cast.org.cn/joweb/kjdb/CN/10.3981/j.issn.1000-7857.2018.06.009
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2种不同金属材料的力学参数
科 属数 种数 占总种数比例 属 种数 占总种数比例 鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78 小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39 多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39 红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87 小菇属 Mycena 11 5.26 光柄菇属 Pluteus 5 2.39 红菇属 Russula 17 8.13 栓菌属 Trametes 5 2.39
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