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科技导报 |专题论文 2017 , 35 (21) : 37 -42
肠道微生物样本库:伦理考量和管理规范
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马永慧1, 王军2
作者信息
    1. 厦门大学医学院生命伦理研究中心, 厦门 361102;
    2. 中国科学院微生物研究所, 北京 100101
通讯作者:
王军(通信作者),研究员,研究方向为微生物组学、生物信息和计算,电子信箱:junwang@in.ac.cn
作者简介:
马永慧,讲师,研究方向为生命伦理学,电子信箱:yhma@xmu.edu.cn
Biobanking for human gut microbiome:Ethical and regulatory considerations
  • MA Yonghui1, WANG Jun2
  • Affiliations
      1. Centre for Bioethics, Medical College, Xiamen University, Xiamen 361102, China;
      2. Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
    出版时间: 2017-11-13 doi: 10.3981/j.issn.1000-7857.2017.21.004
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    人体微生物组与健康和疾病的关系是重要的科学问题。而人体微生物样本库的建立是人体微生物组研究的重要基础,这个新兴领域迫切要求对已建立的价值体系和伦理规范进行调整和变革。本文讨论人体微生物样本库建设中的知情同意、样本和数据的所有权、隐私和风险等;并以粪菌库和粪菌移植为典型案例,分析选择"最佳"、"健康"供体所面临的医学和伦理困难;提出了人体微生物样本库监管的政策建议。
    微生物组  /  微生物样本库  /  伦理  /  管理规范
    Human microbiome research and its relationship with health and disease have increasingly become a hot area in biomedical science. Biobanking human microbiome is fundamental for the development of human microbiome research. However, human microbiome research and biobank are facing many serious ethical, social and regulatory challenges that must be addressed. In this article, we examine three core ethical and social issues, i.e., informed consent, ownership, privacy and risks. Next, we employ fecal microbiota bank and fecal microbiota transplantation as a case study to discuss how to determine a suitable healthy donor. We conclude the article by providing some regulatory and governance suggestions for policy makers to develop successful policy response.
    human microbiome  /  biobank  /  bioethics  /  regulation
    马永慧, 王军. 肠道微生物样本库:伦理考量和管理规范. 科技导报, 2017 , 35 (21) : 37 -42 . DOI: 10.3981/j.issn.1000-7857.2017.21.004
    MA Yonghui, WANG Jun. Biobanking for human gut microbiome:Ethical and regulatory considerations[J]. Science & Technology Review, 2017 , 35 (21) : 37 -42 . DOI: 10.3981/j.issn.1000-7857.2017.21.004

      国家社会科学基金项目(16CZX064)

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    doi: 10.3981/j.issn.1000-7857.2017.21.004
    • 接收时间:2017-08-20
    • 首发时间:2017-11-16
    • 出版时间:2017-11-13
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    • 收稿日期:2017-08-20
    • 修回日期:2017-10-19
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    通讯作者:

    王军(通信作者),研究员,研究方向为微生物组学、生物信息和计算,电子信箱:junwang@in.ac.cn
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    2种不同金属材料的力学参数

    Family
    属数
    Number of
    genus
    种数
    Number of
    species
    占总种数比例
    Percentage of
    total species (%)

    Genus
    种数
    Number of
    species
    占总种数比例
    Percentage of total
    species (%)
    鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
    小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
    多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
    红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
    小菇属 Mycena 11 5.26
    光柄菇属 Pluteus 5 2.39
    红菇属 Russula 17 8.13
    栓菌属 Trametes 5 2.39
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