Article(id=1242136059182654404, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242136040736109467, articleNumber=null, orderNo=13, doi=10.3981/j.issn.1000-7857.2017.10.008, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1456934400000, receivedDateStr=2016-03-03, revisedDate=1481558400000, revisedDateStr=2016-12-13, acceptedDate=null, acceptedDateStr=null, onlineDate=1495691321933, onlineDateStr=2017-05-25, pubDate=1495900800000, pubDateStr=2017-05-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1495691321933, onlineIssueDateStr=2017-05-25, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774077914277, creator=sys-migrate, updateTime=1774077914277, updator=sys-migrate, issue=Issue{id=1242136040736109467, tenantId=1146029695717560320, journalId=1146031591421210625, year='2017', volume='35', issue='10', pageStart='1', pageEnd='108', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774077909878, creator=sys-migrate, updateTime=1774077909878, updator=sys-migrate, preIssue=null, nextIssue=null, ext=null, issueFiles=null}, startPage=64, endPage=70, ext={EN=ArticleExt(id=1242136063695729633, articleId=1242136059182654404, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Protective effect of dietary 5'-nucleotides on alcohol-induced kidney injury of mice, columnId=1242116080374710456, journalTitle=Science & Technology Review, columnName=Articles, runingTitle=null, highlight=null, articleAbstract=This paper investigates the protective effects of dietary 5'-nucleotides on alcohol-induced kidney injury of mice. A total of 35 specific pathogen free (SPF) male Wistar mice are randomly divided into 5 groups given alcohol, equivalent distilled water or an isocaloric amount of dextrose intragastrically for 8 weeks. The two groups of alcohol-induced rats are fed with AIN-93G rodent diets including 0.04% and 0.16% 5'-nucleotides, respectively. Body weight (bw), renal function indexes and serum concentration of ICAM-1 and PCM-1 are measured, and renal pathologic changes stained by hematoxylin and eosin stain are observed by election microscope. The result shows that dietary 5'-nucleotides can reduce the rise of urinary protein per 24 h and level of blood serum creatinine (SCr) induced by alcohol, as well as the blood urea nitrogen (BUN) in the 0.16% NTs group. And compared to the alcohol group, the endogenous creatinine clearance are decreased significantly in the 0.04% and 0.16% NTs groups. The renal lesions present glomerular mesangium proliferation, inflammatory cell infiltration in tubule-interstitial and vacuolation or swell of renal tubule epithelium in the alcohol group, which are less in both NTs groups. The serum concentrations of ICAM-1 and PCM-1 of NTs groups are also lower than those of the alcohol group. What's more, the expression changes of PCX-1, TGF-β and fibronectin (FN) in kidney induced by alcohol are repaired by NTs supplement. In conclusion, the dietary 5'-nucleotides can protect kidney from injury induced by alcohol in mice., correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=egE/GTudlt+gFheZKvxodA==, pdfFileSize=5530785, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=Department of Nutrition and Food Hygiene, School of Public Health, Peking University Health Science Center, Beijing 100191, China, fund=null, authors=WANG Nan, CAI Xiaxia, BAO Lei, LIU Rui, REN Jinwei, XU Meihong, LI Yong, authorsList=WANG Nan, CAI Xiaxia, BAO Lei, LIU Rui, REN Jinwei, XU Meihong, LI Yong), CN=ArticleExt(id=1242136062252884970, articleId=1242136059182654404, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=膳食5'-核苷酸对大鼠酒精性肾损伤保护作用的研究, columnId=1146540929516700224, journalTitle=科技导报, columnName=研究论文, runingTitle=null, highlight=null, articleAbstract=为研究膳食5'-核苷酸对大鼠酒精性肾损伤的保护作用，选取35只SPF级雄性Wistar大鼠，随机分成5组：普通对照组、酒精组、葡萄糖等热量组、酒精+0.04%核苷酸干预组、酒精+0.16%核苷酸干预组。连续灌胃8周后，测定体重、肾体比、血肌酐（SCr）、尿肌酐（UCr）、血尿素氮（BUN）及24 h尿蛋白等相关指标；计算内生肌酐清除率（Ccr）；检测血清炎症因子细胞间黏附分子-1（ICAM-1）、单核细胞趋化因子-1（MCP-1）水平；HE染色观察肾脏组织病理学改变；免疫组化法观察肾脏足细胞标志蛋白PCX-1、肾间质转化生长因子-β（TGF-β）和纤连蛋白（FN）的表达。结果表明：膳食5'-核苷酸能够降低酒精引起的大鼠24 h尿蛋白、血肌酐升高并提高内生肌酐清除率（P<0.05），0.16%核苷酸干预组还能显著降低酒精引起的大鼠血尿素氮升高（P<0.05）；减轻酒精导致的肾脏组织结构病理改变及血清炎症因子ICAM-1、MCP-1水平的升高（P<0.05）；同时减轻甚至逆转酒精导致的肾脏PCX-1、TGF-β和FN表达的改变。由此可知，膳食5'-核苷酸可以通过减轻血液炎症反应，调节肾脏蛋白质分子的表达，对酒精造成的大鼠肾损伤产生一定的保护作用。, correspAuthors=null, authorNote=王楠,硕士研究生,研究方向为营养与疾病,电子信箱:wangnan0818@sina.com。, correspAuthorsNote=李勇(通信作者),教授,研究方向为营养与疾病,电子信箱:li-yong@bjmu.edu.cn, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=uCEjJ0QxZ80/EDTSRDEJIw==, pdfFileSize=5530785, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=北京大学医学部公共卫生学院营养与食品卫生学系, 北京 100191, fund=null, authors=王楠, 蔡夏夏, 鲍雷, 刘睿, 任金威, 徐美虹, 李勇, authorsList=王楠, 蔡夏夏, 鲍雷, 刘睿, 任金威, 徐美虹, 李勇)}, authors=[Author(id=1277122740247200316, tenantId=1146029695717560320, journalId=null, articleId=1242136059182654404, orderNo=null, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=null, email=null, emailSecond=null, emailThird=null, correspondingAuthor=null, authorType=null, ext={}, companyList=null)], keywords=[Keyword(id=1242136061858624464, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242136059182654404, language=CN, orderNo=1, keyword=核苷酸), Keyword(id=1242136061955093457, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242136059182654404, language=CN, orderNo=1, keyword=酒精性肾损伤), Keyword(id=1242136062030590930, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242136059182654404, language=CN, orderNo=1, keyword=保护作用), Keyword(id=1242136062127055848, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242136059182654404, language=CN, orderNo=1, keyword=大鼠), Keyword(id=1242136063293076445, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242136059182654404, language=EN, orderNo=1, keyword=nucleotides), Keyword(id=1242136063372768222, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242136059182654404, language=EN, orderNo=1, keyword=alcoholic renal injury), Keyword(id=1242136063452459999, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242136059182654404, language=EN, orderNo=1, keyword=protective effect), Keyword(id=1242136063540540384, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242136059182654404, language=EN, orderNo=1, keyword=rats)], refs=null, funds=null, companyList=null, figs=null, attaches=null, journal=Journal(id=1125356956822126595, delFlag=0, nameCn=科技导报, nameEn=Science & Technology Review, nameHistory1=null, nameHistory2=null, issn=1000-7857, eissn=, cn=11-1421/N, coden=null, periodic=3, language=CN, oaType=0, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=aEuqdCNQUjPEKa3rm5A/8Q==, journalPrice=null, startedYear=null, abbrevIsoEn=Sci Technol Rev, journalRemark=null, publicationField=null, createdTime=null, updatedTime=1754267492363, createdBy=null, updatedBy=13701087609, firstLetterCn=S, firstLetterEn=S, subjectCode=Natural Sciences, subjectName=自然科学, subjectCodeEn=Natural Sciences, subjectNameEn=null, picCn=aEuqdCNQUjPEKa3rm5A/8Q==, picEn=4AIQ9/oc3H8lvjeELJ6WWw==, jcr=null, cjcr=null, exts=[JournalExt(id=1159045127382855686, language=CN, name=科技导报, nameHistory1=null, nameHistory2=null, managedBy=中国科学技术协会, sponsoredBy=中国科学技术协会, publishedBy=科技导报社, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=null, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=http://www.kjdb.org/CN/home, createdTime=1754267492385, updatedTime=1754267492385, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=http://www.kjdb.org/CN/column/column7.shtml, submissionAuthorUrl=https://kjdbauthor.cast.org.cn/webm, submissionEditorUrl=https://kjdbeditor.cast.org.cn/webm/, submissionReviewUrl=https://kjdbauthor.cast.org.cn/webm, submissionCeEditorUrl=https://kjdbeditor.cast.org.cn/webm/, submissionAeEditorUrl=https://kjdbeditor.cast.org.cn/webm/, option={"copyright":""}), JournalExt(id=1159045127433187335, language=EN, name=Science & Technology Review, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=null, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=http://www.kjdb.org/EN/home, createdTime=1754267492398, updatedTime=1754267492398, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=http://www.kjdb.org/EN/column/column7.shtml, submissionAuthorUrl=https://kjdbauthor.manuscriptcloud.com/login, submissionEditorUrl=https://kjdbeditor.manuscriptcloud.com/login, submissionReviewUrl=https://kjdbauthor.manuscriptcloud.com/login, submissionCeEditorUrl=https://kjdbeditor.manuscriptcloud.com/login, submissionAeEditorUrl=https://kjdbeditor.manuscriptcloud.com/login, option={"copyright":""})], databaseList=null, tenantJournalId=1146031591421210625, websiteList=[Website(id=1146104741081231361, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1146031591421210625, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/kjdb/CN, language=CN, createTime=1751182263881, createBy=18614031015, updateTime=1751778001962, updateBy=18614031015, name=科技导报, tplId=1146099689490845704, title=科技导报, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1148021146403992296, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=articleTextType, value=kx, createTime=1751639170504, updateTime=1751639170504, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146378826469, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=banner, value=null, createTime=1751639170498, updateTime=1751639170498, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146366243556, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=logo, value=https://castjournals.cast.org.cn/joweb/kjdb/CN/file/pic?fileId=9GHSf7eGlIPH0Tv/OOdstA==, createTime=1751639170495, updateTime=1751639170495, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146395603687, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/kjdb/CN/file/pic, createTime=1751639170502, updateTime=1751639170502, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146387215078, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1751639170500, updateTime=1751639170500, creator=18614031015, updator=18614031015)]), Website(id=1146105254833139715, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1146031591421210625, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/kjdb/EN, language=EN, createTime=1751182386363, createBy=18614031015, updateTime=1753500121937, updateBy=18614031015, name=科技导报, tplId=1146101810881728533, title=Science & Technology Review, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1155838567709528217, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=articleTextType, value=kx, createTime=1753502988984, updateTime=1753502988984, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567692750998, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=banner, value=null, createTime=1753502988980, updateTime=1753502988980, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567688556693, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=logo, value=https://castjournals.cast.org.cn/joweb/kjdb/EN/file/pic?fileId=9GHSf7eGlIPH0Tv/OOdstA==, createTime=1753502988979, updateTime=1753502988979, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567705333912, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/kjdb/EN/file/pic, createTime=1753502988983, updateTime=1753502988983, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567701139607, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1753502988982, updateTime=1753502988982, creator=18614031015, updator=18614031015)])], journalTitle=科技导报, weixinUrl=null, journalUrl=null, iacademicId=null, status=0, seqNo=null, journalTitleEn=Science & Technology Review, journalPhotoCn=aEuqdCNQUjPEKa3rm5A/8Q==, journalPhotoEn=4AIQ9/oc3H8lvjeELJ6WWw==, journalFirstLetter=S, journalRecommend=null, journalNew=null, journalCollection=1, jcrJf=null, cjcrJf=0.91, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=null, provinceCode=null, provinceName=null, collectFlag=false), detailUrlCn=https://castjournals.cast.org.cn/joweb/kjdb/CN/10.3981/j.issn.1000-7857.2017.10.008, detailUrlEn=https://castjournals.cast.org.cn/joweb/kjdb/EN/10.3981/j.issn.1000-7857.2017.10.008, pdfUrlCn=https://castjournals.cast.org.cn/joweb/kjdb/CN/PDF/10.3981/j.issn.1000-7857.2017.10.008, pdfUrlEn=https://castjournals.cast.org.cn/joweb/kjdb/EN/PDF/10.3981/j.issn.1000-7857.2017.10.008, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, reference=null)