Article(id=1242135763744268500, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242135748065964300, articleNumber=null, orderNo=14, doi=10.3981/j.issn.1000-7857.2017.04.007, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1481472000000, receivedDateStr=2016-12-12, revisedDate=1484236800000, revisedDateStr=2017-01-13, acceptedDate=null, acceptedDateStr=null, onlineDate=1488252289047, onlineDateStr=2017-02-28, pubDate=1488211200000, pubDateStr=2017-02-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1488252289047, onlineIssueDateStr=2017-02-28, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774077843839, creator=sys-migrate, updateTime=1774077843839, updator=sys-migrate, issue=Issue{id=1242135748065964300, tenantId=1146029695717560320, journalId=1146031591421210625, year='2017', volume='35', issue='4', pageStart='1', pageEnd='100', issueExtLink='null', onlineDate='null', pubDate='1488211200000', pubDateStr='2017-02-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774077840100, creator='sys-migrate', updateTime=1774077840100, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=45, endPage=48, ext={EN=ArticleExt(id=1242135767091323115, articleId=1242135763744268500, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Recent advances in Parkinson's disease, columnId=1242116903087440448, journalTitle=Science & Technology Review, columnName=Spescial Issues, runingTitle=null, highlight=null, articleAbstract=Parkinson's disease (PD) is a common neurodegenerative disorder. The clinical symptoms involve motor syndromes, such as bradykinesia, tremor, rigidity and gait disturbance, and non-motor syndromes, such as olfactory dysfunction, depression and constipation. The mechanism is still unknown. According to the classic pathology, it is the degeneration of dopaminergic neuron and Lewy body. However, this cannot explain all the manifestations. The studies of PD see a great progress in recent years. Our review focuses mainly on the biomarker, brain network and neuromodulation in PD., authors=FENG Tao^1,2,3, MA Lingyan^1,2, authorsList=FENG Tao, MA Lingyan, authorCompany=1. Center of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China;
2. Beijing Institute for Brain Disorders, Beijing 100069, China;
3. China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=NaWYp9ndmYgbI1ZynskAgw==, pdfFileSize=513659, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242135766185353439, articleId=1242135763744268500, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=帕金森病研究进展, columnId=1242116902361830275, journalTitle=科技导报, columnName=专题论文, runingTitle=null, highlight=null, articleAbstract=帕金森病（PD）是常见的神经系统变性疾病，典型的PD病理表现为脑中黑质多巴胺神经元退行性变和路易小体沉积，但这些改变不能完全解释PD产生的临床症状，目前PD的发病原因及机制尚不明确，尚未建立系统的早期诊断及保护治疗方式。随着诊断及治疗技术的提高，生物学标记物、脑网络及神经调控等有望为PD早期诊断、机制探索及个体化治疗提供基础。本文综述了PD在生物学标记物、脑网络研究及神经调控治疗领域的研究进展。, authors=冯涛^1,2,3, 马凌燕^1,2, authorsList=冯涛, 马凌燕, authorCompany=1. 首都医科大学附属北京天坛医院神经病学中心, 北京 100050;
2. 北京脑重大疾病研究院, 北京 100069;
3. 首都医科大学附属北京天坛医院国家神经系统疾病临床医学研究中心, 北京 100050, correspAuthors=null, authorNote=冯涛,主任医师,研究方向为神经变性疾病,电子信箱:happyft@sina.com, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=BQTkOdPfjNa/Xov8iPOsaw==, pdfFileSize=513659, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=国家自然科学基金项目（81571226）；北京市科技计划专项（Z151100003915117）；北京市科技计划项目（Z151100003915150）)}, authors=null, keywords=[Keyword(id=1242135765761728727, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242135763744268500, language=CN, orderNo=1, keyword=帕金森病), Keyword(id=1242135765874974937, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242135763744268500, language=CN, orderNo=1, keyword=生物学标记物), 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