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癫痫的发病机制研究进展
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科技导报 |专题论文 2017 , 35 (4) : 54 -59
癫痫的发病机制研究进展
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杨华俊1,2,3, 郭安臣1,2,3, 王群1,2,3
作者信息
    1. 首都医科大学附属北京天坛医院神经病学中心, 北京 100050;
    2. 北京脑重大疾病研究院, 北京 100069;
    3. 首都医科大学附属北京天坛医院国家神经系统疾病临床医学研究中心, 北京 100050
通讯作者:
王群(通信作者),主任医师,研究方向为癫痫基础与临床、脑血管病基础,电子信箱:wangq@ccmu.edu.cn
作者简介:
杨华俊,博士研究生,研究方向为癫痫基础与临床,电子信箱:doctor_yanghuajun@126.com
Advances in pathogenesis of epilepsy
  • YANG Huajun1,2,3, GUO Anchen1,2,3, WANG Qun1,2,3
  • Affiliations
      1. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China;
      2. Beijing Institute for Brain Disorders, Beijing 100069, China;
      3. China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
    出版时间: 2017-02-28 doi: 10.3981/j.issn.1000-7857.2017.04.009
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    癫痫是神经系统的常见疾病之一,其发病机制十分复杂,目前尚未完全阐明。近年来,关于癫痫发病机制的研究表明,癫痫的发生与离子通道、神经递质、突触连接、神经血管单元、神经胶质细胞等均存在密切联系。为深入理解癫痫发病机制,为诊断、预防与治疗癫痫提供必要的理论依据,本文从离子通道、神经突触传递与连接、神经血管单元完整性、神经胶质细胞4个方面对癫痫发生机制的研究进展做一综述。
    癫痫  /  发病机制  /  离子通道  /  神经递质  /  突触连接
    The epilepsy is one of the most common diseases of the nervous system, and its pathogenesis is very complex. In recent years, studies of the pathogenesis of the epilepsy have shown that the occurrence of the epilepsy is closely related to the ion channels, the neurotransmitters, the synaptic connections, the neurovascular units and the glial cells. This review focuses on the pathogenesis of the epilepsy and the theoretical basis for the diagnosis, the prevention and the treatment of the epilepsy.
    epilepsy  /  pathogenesis  /  ion channel  /  neurotransmitter  /  synaptic connection
    杨华俊, 郭安臣, 王群. 癫痫的发病机制研究进展. 科技导报, 2017 , 35 (4) : 54 -59 . DOI: 10.3981/j.issn.1000-7857.2017.04.009
    YANG Huajun, GUO Anchen, WANG Qun. Advances in pathogenesis of epilepsy[J]. Science & Technology Review, 2017 , 35 (4) : 54 -59 . DOI: 10.3981/j.issn.1000-7857.2017.04.009

      国家自然科学基金项目(81271312);首都卫生发展科研专项(首发2016-1-2011);北京市医院管理局临床新技术创新项目(XMLX201401)

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    doi: 10.3981/j.issn.1000-7857.2017.04.009
    • 接收时间:2016-12-28
    • 首发时间:2017-02-28
    • 出版时间:2017-02-28
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    • 修回日期:2017-02-13
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    王群(通信作者),主任医师,研究方向为癫痫基础与临床、脑血管病基础,电子信箱:wangq@ccmu.edu.cn
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    鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
    小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
    多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
    红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
    小菇属 Mycena 11 5.26
    光柄菇属 Pluteus 5 2.39
    红菇属 Russula 17 8.13
    栓菌属 Trametes 5 2.39
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