Article(id=1242135637680268094, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242135623360914167, articleNumber=null, orderNo=12, doi=10.3981/j.issn.1000-7857.2017.01.007, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1483027200000, receivedDateStr=2016-12-30, revisedDate=1483804800000, revisedDateStr=2017-01-08, acceptedDate=null, acceptedDateStr=null, onlineDate=1487226472897, onlineDateStr=2017-02-16, pubDate=1484236800000, pubDateStr=2017-01-13, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1487226472897, onlineIssueDateStr=2017-02-16, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774077813783, creator=sys-migrate, updateTime=1774077813783, updator=sys-migrate, issue=Issue{id=1242135623360914167, tenantId=1146029695717560320, journalId=1146031591421210625, year='2017', volume='35', issue='1', pageStart='1', pageEnd='164', issueExtLink='null', onlineDate='null', pubDate='1484236800000', pubDateStr='2017-01-13', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774077810369, creator='sys-migrate', updateTime=1774077810369, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=55, endPage=63, ext={EN=ArticleExt(id=1242135641874572123, articleId=1242135637680268094, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Hot spots of life sciences in 2016, columnId=1242116903087440448, journalTitle=Science & Technology Review, columnName=Spescial Issues, runingTitle=null, highlight=null, articleAbstract=The live and fresh characteristics of life and the complexity of the laws of its activities make any new discoveries to attract worldwide attention. Research advances in the field of life sciences in 2016 have been soul-stirring. This paper selects several cases from the research results, which are too numerous to enumerate, to review the typical study progress in this year. The selected cases are:cancer cell induced death of endothelial cells, new type of ectopic inhibitor against drug resistance gene mutation lung cancers, gene targeting scheme that may greatly reduce off-targeting phenomenon, accurate tumor-killing therapy using modified T cells with dual receptor high efficient tumor immunological, therapy, high efficient AIDS immunological therapy, with HIV universal effect anti-virus antibodies, the therapy of autoimmune diseases with the removal of lymphocytes which attacking the patients' own tissues, as well as the crystal regeneration innovation, the resolution of the mechanism of synaptic pruning. Extraordinarily, the problems of tumor treatment, gene editing and so on, have maintained a constant heat, and in 2016, outstanding achievements were still made., authors=LIANG Qianjin, authorsList=LIANG Qianjin, authorCompany=College of Life Sciences, Beijing Normal University, Beijing 100875, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=+RKIFtSwNUcghm8mIAY1qQ==, pdfFileSize=3821042, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242135640414958447, articleId=1242135637680268094, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=2016年生命科学热点回眸, columnId=1242116902361830275, journalTitle=科技导报, columnName=专题论文, runingTitle=null, highlight=null, articleAbstract=生命的鲜活特点及其活动规律的复杂性，使得其研究中任一新发现都备受世人关注。2016年，生命科学领域的研究进展振奋人心。本文从不胜枚举的研究成果中选择了几例，介绍和评述了2016年在癌细胞诱导的内皮细胞死亡、耐药性基因突变的新型肺癌异位抑制剂、极大程度减少脱靶现象的基因靶向方案、利用双重受体改造型T细胞的精确肿瘤杀伤疗法、肿瘤高效免疫疗法、利用HIV病毒普效性抗体的艾滋病高效免疫疗法、可特异清除攻击病人自身组织淋巴细胞的自身免疫病疗法，以及晶体再生手术的革新、神经突触剪切机理的解析等方面的研究进展。特别是肿瘤治疗问题、基因编辑问题等，几乎一直保持着持续的热度，而在2016年又取得卓著成果。, authors=梁前进, authorsList=梁前进, authorCompany=北京师范大学生命科学学院, 北京 100875, correspAuthors=null, authorNote=梁前进,教授,研究方向为分子细胞遗传与功能基因,电子信箱:lqj@bnu.edu.cn, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=J7TmRpN4dT0nOfcLTFppUQ==, pdfFileSize=3821042, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=国家自然科学基金项目（31571394）；抗性基因资源与分子发育北京市重点实验室开放基金项目（201504）)}, authors=null, keywords=[Keyword(id=1242135639685145414, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242135637680268094, language=CN, orderNo=1, keyword=生命科学), Keyword(id=1242135639756448583, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242135637680268094, language=CN, orderNo=1, keyword=肿瘤), Keyword(id=1242135639852917576, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242135637680268094, language=CN, orderNo=1, keyword=基因治疗), Keyword(id=1242135639924220745, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242135637680268094, language=CN, orderNo=1, keyword=免疫治疗), Keyword(id=1242135640008106826, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242135637680268094, language=CN, orderNo=1, keyword=艾滋病), Keyword(id=1242135640104579946, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242135637680268094, language=CN, orderNo=1, keyword=自身免疫病), Keyword(id=1242135640188466027, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242135637680268094, language=CN, orderNo=1, keyword=基因编辑), Keyword(id=1242135640272352108, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242135637680268094, language=CN, orderNo=1, keyword=组织再生), Keyword(id=1242135641165734739, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242135637680268094, language=EN, orderNo=1, keyword=life sciences), Keyword(id=1242135641258009428, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242135637680268094, language=EN, orderNo=1, keyword=cancer), Keyword(id=1242135641333506901, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242135637680268094, language=EN, orderNo=1, keyword=gene therapy), Keyword(id=1242135641413198678, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242135637680268094, language=EN, orderNo=1, keyword=immunotherapy), Keyword(id=1242135641480307543, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242135637680268094, language=EN, orderNo=1, keyword=HIV), Keyword(id=1242135641559999320, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242135637680268094, language=EN, orderNo=1, keyword=autoimmune disease), Keyword(id=1242135641631302489, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242135637680268094, language=EN, orderNo=1, keyword=gene editing), Keyword(id=1242135641731965786, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242135637680268094, language=EN, orderNo=1, keyword=tissue regeneration)], refs=null, funds=null, companyList=null, figs=null, attaches=null, journal=Journal(id=1125356956822126595, delFlag=0, nameCn=科技导报, nameEn=Science & Technology Review, nameHistory1=null, nameHistory2=null, issn=1000-7857, eissn=, cn=11-1421/N, coden=null, periodic=3, language=CN, oaType=0, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=wfghvu3bhh/dKxuZ+ucVHA==, journalPrice=null, startedYear=null, abbrevIsoEn=Sci Technol Rev, journalRemark=null, publicationField=null, createdTime=null, updatedTime=1784015846012, createdBy=null, updatedBy=13041195026, firstLetterCn=K, firstLetterEn=K, subjectCode=Natural Sciences, subjectName=自然科学, subjectCodeEn=Natural Sciences, subjectNameEn=null, picCn=wfghvu3bhh/dKxuZ+ucVHA==, picEn=yjSfclmpNm7ihn9NbTZ69g==, jcr=null, cjcr=null, exts=[JournalExt(id=1283818766098219763, language=CN, name=科技导报, nameHistory1=null, nameHistory2=null, managedBy=中国科学技术协会, sponsoredBy=中国科学技术协会, publishedBy=科技导报社, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=http://www.kjdb.org/CN/home, createdTime=1784015846037, updatedTime=1784015846037, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=http://www.kjdb.org/CN/column/column7.shtml, submissionAuthorUrl=https://kjdbauthor.cast.org.cn/webm, submissionEditorUrl=https://kjdbeditor.cast.org.cn/webm/, submissionReviewUrl=https://kjdbauthor.cast.org.cn/webm, submissionCeEditorUrl=https://kjdbeditor.cast.org.cn/webm/, submissionAeEditorUrl=https://kjdbeditor.cast.org.cn/webm/, option={"copyright":""}), JournalExt(id=1283818766144357108, language=EN, name=Science & Technology Review, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=http://www.kjdb.org/EN/home, createdTime=1784015846048, updatedTime=1784015846048, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=http://www.kjdb.org/EN/column/column7.shtml, submissionAuthorUrl=https://kjdbauthor.manuscriptcloud.com/login, submissionEditorUrl=https://kjdbeditor.manuscriptcloud.com/login, submissionReviewUrl=https://kjdbauthor.manuscriptcloud.com/login, submissionCeEditorUrl=https://kjdbeditor.manuscriptcloud.com/login, submissionAeEditorUrl=https://kjdbeditor.manuscriptcloud.com/login, option={"copyright":""})], databaseList=null, tenantJournalId=1146031591421210625, websiteList=[Website(id=1146104741081231361, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1146031591421210625, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/kjdb/CN, language=CN, createTime=1751182263881, createBy=18614031015, updateTime=1751778001962, updateBy=18614031015, name=科技导报, tplId=1146099689490845704, title=科技导报, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1148021146403992296, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=articleTextType, value=kx, createTime=1751639170504, updateTime=1751639170504, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146378826469, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=banner, value=null, createTime=1751639170498, updateTime=1751639170498, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146366243556, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=logo, value=https://castjournals.cast.org.cn/joweb/kjdb/CN/file/pic?fileId=9GHSf7eGlIPH0Tv/OOdstA==, createTime=1751639170495, updateTime=1751639170495, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146395603687, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/kjdb/CN/file/pic, createTime=1751639170502, updateTime=1751639170502, creator=18614031015, updator=18614031015), WebsiteProps(id=1148021146387215078, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146104741081231361, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1751639170500, updateTime=1751639170500, creator=18614031015, updator=18614031015)]), Website(id=1146105254833139715, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1146031591421210625, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/kjdb/EN, language=EN, createTime=1751182386363, createBy=18614031015, updateTime=1753500121937, updateBy=18614031015, name=科技导报, tplId=1146101810881728533, title=Science & Technology Review, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1155838567709528217, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=articleTextType, value=kx, createTime=1753502988984, updateTime=1753502988984, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567692750998, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=banner, value=null, createTime=1753502988980, updateTime=1753502988980, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567688556693, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=logo, value=https://castjournals.cast.org.cn/joweb/kjdb/EN/file/pic?fileId=9GHSf7eGlIPH0Tv/OOdstA==, createTime=1753502988979, updateTime=1753502988979, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567705333912, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/kjdb/EN/file/pic, createTime=1753502988983, updateTime=1753502988983, creator=18614031015, updator=18614031015), WebsiteProps(id=1155838567701139607, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1146105254833139715, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1753502988982, updateTime=1753502988982, creator=18614031015, updator=18614031015)])], journalTitle=科技导报, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Science & Technology Review, journalPhotoCn=wfghvu3bhh/dKxuZ+ucVHA==, journalPhotoEn=yjSfclmpNm7ihn9NbTZ69g==, journalFirstLetter=K, journalRecommend=null, journalNew=null, journalCollection=1, jcrJf=null, cjcrJf=0.91, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/kjdb/CN/10.3981/j.issn.1000-7857.2017.01.007, detailUrlEn=https://castjournals.cast.org.cn/joweb/kjdb/EN/10.3981/j.issn.1000-7857.2017.01.007, pdfUrlCn=https://castjournals.cast.org.cn/joweb/kjdb/CN/PDF/10.3981/j.issn.1000-7857.2017.01.007, pdfUrlEn=https://castjournals.cast.org.cn/joweb/kjdb/EN/PDF/10.3981/j.issn.1000-7857.2017.01.007, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1484236800000, fullTextJson=null, articleText=null, reference=null)