Article(id=1242135581350769286, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242135568784630300, articleNumber=null, orderNo=11, doi=10.3981/j.issn.1000-7857.2016.24.006, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1472486400000, receivedDateStr=2016-08-30, revisedDate=1476720000000, revisedDateStr=2016-10-18, acceptedDate=null, acceptedDateStr=null, onlineDate=1486437841177, onlineDateStr=2017-02-07, pubDate=1482854400000, pubDateStr=2016-12-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1486437841177, onlineIssueDateStr=2017-02-07, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774077800353, creator=sys-migrate, updateTime=1774077800353, updator=sys-migrate, issue=Issue{id=1242135568784630300, tenantId=1146029695717560320, journalId=1146031591421210625, year='2016', volume='34', issue='24', pageStart='1', pageEnd='143', issueExtLink='null', onlineDate='null', pubDate='1482854400000', pubDateStr='2016-12-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774077797358, creator='sys-migrate', updateTime=1774077797358, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=44, endPage=55, ext={EN=ArticleExt(id=1242135588065850032, articleId=1242135581350769286, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=An analysis on global drug development status of rheumatoid arthritis, columnId=1242116810380743325, journalTitle=Science & Technology Review, columnName=Reviews, runingTitle=null, highlight=null, articleAbstract=Rheumatoid arthritis (RA) is an autoimmune disease, which is a worldwide disease, with a global prevalence rate of about 0.24%. RA pathogenesis is complex and has a high disability rate, depressing the life quality of patients seriously and aggravating the economic burden of the society. Effective treatment of RA has become a focus of the global pharmaceutical industry. According to the IMS Health statistics, the global drug expenditure for the treatment of RA amounted to $21.4 billion in 2015. This paper uses literature investigation, database search, such as Thomson Reuters, IMS Health etc., as well as data statistics and analysis, to make an analysis on the global RA drug development status, market, targets, patent and other information. Medicine treatment for RA includes anti-inflammatory drugs, anti-rheumatic drugs, hormone drugs, biological agents, combination of drugs, immune reconstitution, etc. Therapeutic target involves tumor necrosis factor alpha, cycloxygenase, B-lymphocyte antigen, interleukin, nuclear transcription factor kB, small molecule kinase and so on. In recent years, the development of biotechnology drugs in the treatment of RA and other autoimmune diseases has made an unprecedented success, small molecule drugs and biosimilar products will also play an important role in the future market., authors=LIU Lili, MAO Yanyan, GAO Liubin, authorsList=LIU Lili, MAO Yanyan, GAO Liubin, authorCompany=Intelligence Research Department, Information Center, Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai 201203, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=BG1rJOQWKDI73dkfSGuDsQ==, pdfFileSize=7181110, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242135586367156903, articleId=1242135581350769286, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=类风湿关节炎全球药物研发状况分析, columnId=1242116809164390686, journalTitle=科技导报, columnName=综述文章, runingTitle=null, highlight=null, articleAbstract=类风湿关节炎（RA）是一种自身免疫性疾病，全球患病率约0.24%。RA发病机制复杂，致残率极高，严重影响患者的生活质量，给社会带来沉重的经济负担，对RA的有效治疗成为全球医药行业关注的重点。据艾美仕数据统计，2015年全球医药市场用于治疗RA的药物支出达214亿美元。本报告依据相关文献及Thomson Reuters、IMS Health等数据库信息，对RA全球药物研发市场、治疗药物类别、靶标、专利等药物研发状况进行分析。目前，RA治疗药物类别包括抗炎药、抗风湿药、激素类药物、生物制剂、联合用药、免疫重建等；治疗靶标有肿瘤坏死因子α、环氧化酶类、B-淋巴细胞抗原、白细胞介素类、细胞核转录因子kB、小分子激酶等；近些年，生物技术药物在RA等自身免疫性疾病治疗领域取得了前所未有的成功，未来市场小分子药物及生物仿制药也将会发挥关键作用。, authors=刘丽丽, 毛艳艳, 高柳滨, authorsList=刘丽丽, 毛艳艳, 高柳滨, authorCompany=中国科学院上海药物研究所信息中心, 上海 201203, correspAuthors=null, authorNote=刘丽丽,博士,研究方向为药物情报学,电子信箱:llliu@simm.ac.cn, correspAuthorsNote=高柳滨(通信作者),研究馆员,研究方向为情报学,电子信箱:lbgao@simm.ac.cn, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=CgSZHApyeeE8gV79J0ALpw==, pdfFileSize=7181110, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null)}, authors=null, keywords=[Keyword(id=1242135584450359966, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242135581350769286, language=CN, orderNo=1, keyword=类风湿关节炎), Keyword(id=1242135585926754979, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242135581350769286, language=CN, orderNo=1, keyword=自身免疫性疾病), Keyword(id=1242135586023223972, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242135581350769286, language=CN, orderNo=1, keyword=生物制剂), Keyword(id=1242135586115498661, tenantId=1146029695717560320, journalId=1146031591421210625, articleId=1242135581350769286, language=CN, orderNo=1, keyword=小分子药物), Keyword(id=1242135586207773350, tenantId=1146029695717560320, 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