Article(id=1242134489086899169, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242134390566887892, articleNumber=null, orderNo=43, doi=10.3981/j.issn.1000-7857.2016.2.037, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1428940800000, receivedDateStr=2015-04-14, revisedDate=1448812800000, revisedDateStr=2015-11-30, acceptedDate=null, acceptedDateStr=null, onlineDate=1454555982870, onlineDateStr=2016-02-04, pubDate=1453910400000, pubDateStr=2016-01-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1454555982870, onlineIssueDateStr=2016-02-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774077539934, creator=sys-migrate, updateTime=1774077539934, updator=sys-migrate, issue=Issue{id=1242134390566887892, tenantId=1146029695717560320, journalId=1146031591421210625, year='2016', volume='34', issue='2', pageStart='1', pageEnd='332', issueExtLink='null', onlineDate='null', pubDate='1453910400000', pubDateStr='2016-01-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774077516449, creator='sys-migrate', updateTime=1774077516449, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=221, endPage=225, ext={EN=ArticleExt(id=1242134493738381337, articleId=1242134489086899169, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Effects of TGF-β1 on myocardial fibrosis due to different reasons, columnId=1242116810380743325, journalTitle=Science & Technology Review, columnName=Reviews, runingTitle=null, highlight=null, articleAbstract=Myocardial fibrosis (MF) is a complex pathological process, involving multiple systems, many different mechanisms and a variety of cytokines. Among those cytokines transforming growth factor β1 (TGF-β1) is an important pro-fibrotic factor. In the pathological conditions by classical TGF-β1/smads pathways myocardial fibrosis may be induced and developed eventually to heart failure. In this paper, high blood pressure, diabetes, radiation damage and viral myocarditis mechanisms leading to MF are reviewed, with a focus on the role of TGF-β1 signaling pathway in the MF, so as to provide more specific and effective targets for the prevention and treatment of myocardial fibrosis and heart failure due to different reasons., authors=DING Wenjin¹, AO Bifeng¹, OUYANG Weiwei^1,2, SU Shengfa², LU Bing², authorsList=DING Wenjin, AO Bifeng, OUYANG Weiwei, SU Shengfa, LU Bing, authorCompany=1. Department of Oncology, Affiliated Hospital of Guizhou Medical University; Department of Oncology, Guizhou Cancer Hospital, Guiyang 550004, China;
2. Teaching and Research Section of Oncology, Guiyang Medical University, Guiyang 550001, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=RYqMCQM7z5nxZkBARyXyFw==, pdfFileSize=603794, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242134492387812311, articleId=1242134489086899169, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=TGF-β1在不同原因致心肌纤维化中的作用, columnId=1242116809164390686, journalTitle=科技导报, columnName=综述文章, runingTitle=null, highlight=null, articleAbstract=心肌纤维化(myocardial fibrosis,MF)是一个复杂的病理过程,涉及多系统和多种不同机制,涉及多种细胞因子参与,其中转化生长因子β1(transforming growth factor-β1,TGF-β1)是重要的促纤维化因子,在病理情况下可通过经典的TGF-β1/smads 通路诱导心肌纤维化的发生发展,并最终导致心力衰竭。本文综述了高血压、糖尿病、射线损伤、病毒性心肌炎导致MF的相关机制,阐述了TGF-β1 信号通路在MF 中的作用。, authors=丁文金¹, 敖碧凤¹, 欧阳伟炜^1,2, 苏胜发², 卢冰², authorsList=丁文金, 敖碧凤, 欧阳伟炜, 苏胜发, 卢冰, authorCompany=1. 贵州医科大学附属肿瘤医院肿瘤科;贵州省肿瘤医院肿瘤科, 贵阳 550004;
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