Article(id=1242133856669737007, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242133836251869266, articleNumber=null, orderNo=15, doi=10.3981/j.issn.1000-7857.2015.17.010, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1435766400000, receivedDateStr=2015-07-02, revisedDate=1438272000000, revisedDateStr=2015-07-31, acceptedDate=null, acceptedDateStr=null, onlineDate=1442036797513, onlineDateStr=2015-09-12, pubDate=1442073600000, pubDateStr=2015-09-13, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1442036797513, onlineIssueDateStr=2015-09-12, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774077389158, creator=sys-migrate, updateTime=1774077389158, updator=sys-migrate, issue=Issue{id=1242133836251869266, tenantId=1146029695717560320, journalId=1146031591421210625, year='2015', volume='33', issue='17', pageStart='1', pageEnd='112', issueExtLink='null', onlineDate='null', pubDate='1442073600000', pubDateStr='2015-09-13', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774077384289, creator='sys-migrate', updateTime=1774077384289, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=90, endPage=95, ext={EN=ArticleExt(id=1242133861317025875, articleId=1242133856669737007, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Hyperglycemia induced generation of ADTIQ and dopamine metabolism imbalance, columnId=1242116080374710456, journalTitle=Science & Technology Review, columnName=Articles, runingTitle=null, highlight=null, articleAbstract=Recent studies show that for the type 2 diabetes the Parkinson's disease is more likely to be developed than for normal diabetes, and the 1-acetyl-6, 7-dihydroxyl-1, 2, 3, 4-tetrahydroisoquinoline (ADTIQ) could be a key factor associated with the diabetes and the PD. In the present study, the SH-SY5Y cells are used as a model to investigate the ADTIQ generated conditions. It is found that the hyperglycemia could induce the increase of the endogenous methylglyoxal, which might react with the dopamine to generate the ADTIQ. Again, the hyperglycemia leads to a reduction of the dopamine in the SH-SY5Y cells and the plasma of the type 2 diabetic rats, and an increase of the tyrosine hydroxylase (TH) and the dopamine transporter (DAT). So, the hyperglycemia induces the generation of the ADTIQ and the dopamine metabolism imbalance. The generation of the ADTIQ could play a key role in increasing the risk of the PD in patients with diabetes., authors=XIE Bingjie, WU Hanyan, DENG Yulin, authorsList=XIE Bingjie, WU Hanyan, DENG Yulin, authorCompany=School of Life Science, Beijing Institute of Technology, Beijing 100081, China, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=14S4uCJoywt+ha+RtD/s/Q==, pdfFileSize=1533266, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1242133859207290947, articleId=1242133856669737007, tenantId=1146029695717560320, journalId=1146031591421210625, language=CN, title=高糖诱导ADTIQ的生成和多巴胺的代谢失衡, columnId=1146540929516700224, journalTitle=科技导报, columnName=研究论文, runingTitle=null, highlight=null, articleAbstract=2 型糖尿病患者比正常人更容易患帕金森病(PD),而新内源性神经毒素1-乙酰基-6, 7-二羟基-1, 2, 3,4-四氢异喹啉(ADTIQ)可能成为2 型糖尿病并发PD 的一个关键因素,ADTIQ 是由丙酮醛与多巴胺反应合成,但是其在多巴胺能神经元中的生成条件,以及在糖尿病情况下ADTIQ 的生成是否影响多巴胺代谢尚不清楚。本研究以SH-SY5Y 细胞为模型,研究ADTIQ 在细胞模型中的生成条件,发现ADTIQ 是在葡萄糖代谢旺盛的条件下,丙酮醛内源性产生与神经元内的多巴胺反应生成。研究揭示,高糖条件下,SH-SY5Y 细胞和2 型糖尿病的大鼠模型中外周多巴胺的质量浓度减少,而与多巴胺合成和转运相关的酪氨酸羟化酶和多巴胺转运体合成增加。可见,高糖能诱导SH-SY5Y 细胞内ADTIQ 的生成和多巴胺代谢的失衡,ADTIQ 的生成可能成为糖尿病并发PD 的关键因素。, authors=谢冰洁, 武晗燕, 邓玉林, authorsList=谢冰洁, 武晗燕, 邓玉林, authorCompany=北京理工大学生命学院, 北京100081, correspAuthors=null, authorNote=谢冰洁,博士研究生,研究方向为神经退行性疾病,电子信箱:xiebingjie19860128@126.com, correspAuthorsNote=邓玉林,教授,研究方向为神经退行性疾病,电子信箱:deng@bit.edu.cn, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=CZPDF+w9jjIV/U8nE2ywGg==, pdfFileSize=1533266, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, 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