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中药“十八反”的历史沿革、宜忌争论与思考建议
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科技导报 |学术聚焦 2015 , 33 (16) : 88 -94
中药“十八反”的历史沿革、宜忌争论与思考建议
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欧丽娜1,2, 钟赣生1, 柳海艳1, 陈绍红1, 刘佳1
作者信息
    1. 北京中医药大学基础医学院, 北京 100029;
    2. 河南科技大学医学院, 洛阳 471003
通讯作者:
钟赣生,教授,研究方向为中药基本理论与临床应用,电子信箱:zhonggansheng@sohu.com
作者简介:
欧丽娜,博士研究生,研究方向为中药基本理论与临床应用,电子信箱:lina.ou@163.com
Historical evolution, incompatibility arguments and suggestions on “eighteen incompatible medicaments”
  • OU Lina1,2, ZHONG Gansheng1, LIU Haiyan1, CHEN Shaohong1, LIU Jia1
  • Affiliations
      1. School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China;
      2. Medical College, Henan University of Science and Technology, Luoyang 471003, China
    出版时间: 2015-08-28 doi: 10.3981/j.issn.1000-7857.2015.16.014
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    为分析“十八反”的历史沿革及研究现状、提出下一步开展“十八反”研究的建议, 回顾了“相反”理论的提出、“十八反”歌诀的出现、目前药典对“十八反”的相关规定。从文献记载、临床报道、实验研究3个方面论述了关于“十八反”的宜忌争论。分析整理文献、总结“十八反”在临床研究和实验研究方面的进展, 可以看出临床方面的研究多是从文献的角度, 进行回顾性总结, 从中挖掘整理“十八反”反药组合的临床安全性评价和配伍应用规律。而关于“十八反”的实验研究则主要从化学物质基础、药理学、毒理学等方面开展。
    “十八反”  /  中药配伍  /  宜忌争论
    This paper reviews the antagonism theory and "eighteen incompatible medicaments", as well as the relevant provisions about them in the Pharmacopoeia of China. It provides suggestions for further research concerning the "eighteen incompatible medicaments" through analysis of their historical evolution and the status quo. The incompatibility arguments of the "eighteen incompatible medicaments" are discussed from aspects of literature review, experimental studies and clinical reports. It is found that clinical studies focus on retrospective summary of clinical reports, analyzing clinical safety evaluation and rules of compatible applications. Experimental studies are mostly carried out from aspects of chemical material foundation, pharmacology and toxicology.
    "eighteen incompatible medicaments"  /  compatibility of traditional Chinese medicine  /  incompatibility arguments
    欧丽娜, 钟赣生, 柳海艳, 陈绍红, 刘佳. 中药“十八反”的历史沿革、宜忌争论与思考建议. 科技导报, 2015 , 33 (16) : 88 -94 . DOI: 10.3981/j.issn.1000-7857.2015.16.014
    OU Lina, ZHONG Gansheng, LIU Haiyan, CHEN Shaohong, LIU Jia. Historical evolution, incompatibility arguments and suggestions on “eighteen incompatible medicaments”[J]. Science & Technology Review, 2015 , 33 (16) : 88 -94 . DOI: 10.3981/j.issn.1000-7857.2015.16.014

      国家重点基础研究发展计划(973计划)项目(2011CB505300, 2011CB505306)

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    doi: 10.3981/j.issn.1000-7857.2015.16.014
    • 接收时间:2015-03-19
    • 首发时间:2015-08-28
    • 出版时间:2015-08-28
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    • 收稿日期:2015-03-19
    • 修回日期:2015-06-23
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    钟赣生,教授,研究方向为中药基本理论与临床应用,电子信箱:zhonggansheng@sohu.com
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    鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
    小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
    多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
    红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
    小菇属 Mycena 11 5.26
    光柄菇属 Pluteus 5 2.39
    红菇属 Russula 17 8.13
    栓菌属 Trametes 5 2.39
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