Article(id=1242133251033210953, tenantId=1146029695717560320, journalId=1146031591421210625, issueId=1242133213372556217, articleNumber=null, orderNo=19, doi=10.3981/j.issn.1000-7857.2015.06.017, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1413907200000, receivedDateStr=2014-10-22, revisedDate=1421942400000, revisedDateStr=2015-01-23, acceptedDate=null, acceptedDateStr=null, onlineDate=1428653855057, onlineDateStr=2015-04-10, pubDate=1427472000000, pubDateStr=2015-03-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1428653855057, onlineIssueDateStr=2015-04-10, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1774077244762, creator=sys-migrate, updateTime=1774077244762, updator=sys-migrate, issue=Issue{id=1242133213372556217, tenantId=1146029695717560320, journalId=1146031591421210625, year='2015', volume='33', issue='6', pageStart='1', pageEnd='128', issueExtLink='null', onlineDate='null', pubDate='1427472000000', pubDateStr='2015-03-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=3, issueType=-1, specialIssue=null, createTime=1774077235785, creator='sys-migrate', updateTime=1774077235785, updator='sys-migrate', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=101, endPage=106, ext={EN=ArticleExt(id=1242133256687132792, articleId=1242133251033210953, tenantId=1146029695717560320, journalId=1146031591421210625, language=EN, title=Distribution of endothelial nitric oxide synthase gene intron 4a/b VNTR polymorphism in Uyghur population, columnId=1242116080374710456, journalTitle=Science & Technology Review, columnName=Articles, runingTitle=null, highlight=null, articleAbstract=To investigate the distribution of the intron 4 variable number of tandem repeats (4a/b VNTR) polymorphism of the endothelial nitric oxide synthase (eNOS) gene, 99 unrelated Uyghur healthy individuals (including 38 males and 61 females) are selected and tested by means of polymerase chain reaction (PCR)-agarose gel electrophoresis. All subjects are genotyped for the eNOS gene. It is shown that the frequencies of the aa, ab, bb genotypes are 2.02% (4 cases), 22.22% (22 cases), 75.76% (75 cases), respectively. The genotype frequency and the allele frequency are not related to the sex (P =0.194, P =0.382, P >0.05). The single factor analysis of various physiological and biochemical indexes shows that the differences of all biochemical parameters are not statistically significant (P >0.05). In the Uyghur population, the frequency of the aa+ab genotypes is significantly lower than those of the Henan Han population, the Taiwan Han population, the Northern Han population and the Black Brazil population (P <0.05, P < 0.01), but is significantly higher than that of the Guangdong Han population (P =0.050). A comparison of a, b, c three allele frequencies shows that the Uyghur has a significantly different frequency from those of the Henan Han, the Taiwan Han, the Jilin Han, the Guangdong Han, the French and the Black Brazil (P <0.05, P < 0.01). In short, the eNOS gene 4a/b VNTR is in line with the Hardy-Weinbery balance law (χ 2 =0.017, P =0.991, P >0.05), and the group is representative. It is concluded that there is a significant difference between the Uyghur eNOS gene 4a/b VNTR polymorphism and some ethnic groups., authors=MATYUSUP Dolkun1 , ABDUKERAM Bupatima1 , NIZAM Yilihamu1 , SONG Manshu2 , BAKE Rabiya1 , authorsList=MATYUSUP Dolkun, ABDUKERAM Bupatima, NIZAM Yilihamu, SONG Manshu, BAKE Rabiya, authorCompany=1. College of the Life Science and Technology, Xinjiang University, Urumqi 830046, China;P =0.194, P =0.382, P >0.05)。aa、ab、bb、ab+bb 基因型的各种生理生化指标用单因素方差分析进行比较, 不同基因型的生理生化指标之间的差异无统计学意义(P >0.05)。维吾尔族eNOS 基因4a/b VNTR 多态性与国内外各民族群体进行比较, 维吾尔族人群eNOS 基因aa+ab 基因型频率显著低于河南汉族、中国台湾汉族、北方汉族和巴西黑人(P <0.05, P < 0.01), 明显高于广东汉族(P =0.050)。a、b、c 3 种等位基因进行比较, 维吾尔族与河南汉族、中国台湾汉族、广东汉族、法国人和巴西黑人有显著性差异(P <0.05, P < 0.01)。结果显示, eNOS 基因4a/b VNTR 多态性符合Hardy-Weinbery 遗传平衡规律(χ 2 =0.017, P =0.991, P >0.05), 群体具有代表性。由此得出, 维吾尔族eNOS 基因4a/b VNTR 多态性与国内外的一些民族间存在显著性差异。, authors=多力坤·买买提玉素甫1 , 布帕提玛穆·阿布都克热穆1 , 伊力哈木·乃扎木1 , 宋曼殳2 , 热比亚木·巴克1 , authorsList=多力坤·买买提玉素甫, 布帕提玛穆·阿布都克热穆, 伊力哈木·乃扎木, 宋曼殳, 热比亚木·巴克, authorCompany=1. 新疆大学生命科学与技术学院, 乌鲁木齐830046;
科技导报
| 研究论文 2015, 33(6): 101-106
维吾尔族内皮型一氧化氮合酶基因4a/b VNTR多态性分布特征
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多力坤·买买提玉素甫1 , 布帕提玛穆·阿布都克热穆1 , 伊力哈木·乃扎木1 , 宋曼殳2 , 热比亚木·巴克1
作者信息
1. 新疆大学生命科学与技术学院, 乌鲁木齐830046;
Distribution of endothelial nitric oxide synthase gene intron 4a/b VNTR polymorphism in Uyghur population
Affiliations
出版时间: 2015-03-28
doi: 10.3981/j.issn.1000-7857.2015.06.017
文章导航
应用聚合酶链式反应(PCR)-琼脂糖凝胶电泳技术, 检测99 例(男性38 例, 女性61 例)无血缘关系的维吾尔族健康人群的内皮型—氧化氮合酶(endothelial nitric oxide synthase, eNOS)基因第4 内含子数目可变性串联重复序列(4a/b VNTR)多态性, 探讨eNOS 基因4a/b VNTR 多态性在中国维吾尔族健康人群中的分布特征。结果发现, 99 例健康维吾尔族人群中, aa 基因型频率为2.02%(4 例), ab 基因型频率为22.22%(22 例), bb 基因型频率为75.76%(75 例)。男女两组基因型和等位基因的分布差异不显著(P =0.194, P =0.382, P >0.05)。aa、ab、bb、ab+bb 基因型的各种生理生化指标用单因素方差分析进行比较, 不同基因型的生理生化指标之间的差异无统计学意义(P >0.05)。维吾尔族eNOS 基因4a/b VNTR 多态性与国内外各民族群体进行比较, 维吾尔族人群eNOS 基因aa+ab 基因型频率显著低于河南汉族、中国台湾汉族、北方汉族和巴西黑人(P <0.05, P < 0.01), 明显高于广东汉族(P =0.050)。a、b、c 3 种等位基因进行比较, 维吾尔族与河南汉族、中国台湾汉族、广东汉族、法国人和巴西黑人有显著性差异(P <0.05, P < 0.01)。结果显示, eNOS 基因4a/b VNTR 多态性符合Hardy-Weinbery 遗传平衡规律(χ 2 =0.017, P =0.991, P >0.05), 群体具有代表性。由此得出, 维吾尔族eNOS 基因4a/b VNTR 多态性与国内外的一些民族间存在显著性差异。
维吾尔族
/
内皮型一氧化合酶基因
/
基因多态性
/
数目可变性串联重复序列
To investigate the distribution of the intron 4 variable number of tandem repeats (4a/b VNTR) polymorphism of the endothelial nitric oxide synthase (eNOS) gene, 99 unrelated Uyghur healthy individuals (including 38 males and 61 females) are selected and tested by means of polymerase chain reaction (PCR)-agarose gel electrophoresis. All subjects are genotyped for the eNOS gene. It is shown that the frequencies of the aa, ab, bb genotypes are 2.02% (4 cases), 22.22% (22 cases), 75.76% (75 cases), respectively. The genotype frequency and the allele frequency are not related to the sex (P =0.194, P =0.382, P >0.05). The single factor analysis of various physiological and biochemical indexes shows that the differences of all biochemical parameters are not statistically significant (P >0.05). In the Uyghur population, the frequency of the aa+ab genotypes is significantly lower than those of the Henan Han population, the Taiwan Han population, the Northern Han population and the Black Brazil population (P <0.05, P < 0.01), but is significantly higher than that of the Guangdong Han population (P =0.050). A comparison of a, b, c three allele frequencies shows that the Uyghur has a significantly different frequency from those of the Henan Han, the Taiwan Han, the Jilin Han, the Guangdong Han, the French and the Black Brazil (P <0.05, P < 0.01). In short, the eNOS gene 4a/b VNTR is in line with the Hardy-Weinbery balance law (χ 2 =0.017, P =0.991, P >0.05), and the group is representative. It is concluded that there is a significant difference between the Uyghur eNOS gene 4a/b VNTR polymorphism and some ethnic groups.
Uyghur
/
endothelial nitric oxide synthase gene
/
gene polymorphism
/
variable number of tandem repeats
多力坤·买买提玉素甫, 布帕提玛穆·阿布都克热穆, 伊力哈木·乃扎木, 宋曼殳, 热比亚木·巴克.
维吾尔族内皮型一氧化氮合酶基因4a/b VNTR多态性分布特征.
科技导报,
2015
, 33
(6)
: 101
-106
.
DOI: 10.3981/j.issn.1000-7857.2015.06.017
MATYUSUP Dolkun, ABDUKERAM Bupatima, NIZAM Yilihamu, SONG Manshu, BAKE Rabiya.
Distribution of endothelial nitric oxide synthase gene intron 4a/b VNTR polymorphism in Uyghur population[J].
Science & Technology Review ,
2015
, 33
(6)
: 101
-106
.
DOI: 10.3981/j.issn.1000-7857.2015.06.017
2015年第33卷第6期
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文章信息
doi: 10.3981/j.issn.1000-7857.2015.06.017
接收时间：2014-10-22
首发时间：2015-04-10
出版时间：2015-03-28
收稿日期：2014-10-22
修回日期：2015-01-23
https://castjournals.cast.org.cn/joweb/kjdb/CN/10.3981/j.issn.1000-7857.2015.06.017
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